Syllabus & Schedule [TEXT] [PDF]
Lecture 1 (Aug 31): Taxonomy I: Primary & Secondary Structure [PDF]
Lecture 2 (Sep 5): Taxonomy II: Motifs & Supersecondary Structure [PDF]
Lecture 3 (Sep 7): Taxonomy III: Tertiary Structure & Fold Types [PDF]
Lecture 4 (Sep 12): Folding I: Forces that Determine Protein Structure [PDF]
Lecture 5 (Sep 14): Folding II: Mechanisms of Protein Folding [PDF]
Lecture 6 (Sep 19): Folding III: Characterization of Folding Pathways [PDF]
Lecture 7 (Sep 21): Folding IV: Mutagenesis Studies [PDF]
Lecture 8 (Sep 26): Special Topics I: Electrostatics and Solvation [PDF]
Lecture 9 (Sep 28): Spectroscopy I: Background and Basic Principles [PDF]
Lecture 10 (Oct 3): Spectroscopy II: Absorption and Fluorescence [PDF]
Lecture 11 (Oct 5): Spectroscopy III: Circular Dichroism and Optical Rotation [PDF]
Lecture 12 (Oct 10): Spectroscopy IV: Fluctuation Spectroscopy [PDF]
Lecture 13 (Oct 12): Spectroscopy V: Mass Spectrometry [PDF]
Lecture 14 (Oct 17): Protein Design I: Structural Scaffolds [PDF]
Lecture 15 (Oct 19): Protein Design II: Enzymatic Function [PDF]
Lecture 16 (Oct 26): NMR I: Basic NMR Principles and Parameters [PDF]
Lecture 17 (Oct 31): NMR II: Vector & Product Operator Formalisms [PDF]
Lecture 18 (Nov 2): NMR III: Heteronuclear Correlation Experiments [PDF]
Lecture 19 (Nov 7): NMR IV: Resonance Assignment Strategies [PDF]
Lecture 20 (Nov 9): NMR V: Protein Structure Determination [PDF]
Lecture 21 (Nov 14): Special Topics II: 19F NMR Studies of Protein Folding [PDF]
Lecture 22 (Nov 16): Special Topics III: GPCR Signal Transduction [PDF]
Lecture 23 (Nov 21): NMR VI: Further Applications of NMR [PDF]
Lecture 24 (Nov 28): X-Ray I: Biological Imaging by X-Ray Diffraction [PDF]
Lecture 25 (Nov 30): X-Ray II: Crystals - Growth & Physical Properties [PDF]
Lecture 26 (Dec 5): X-Ray III: X-Ray Data Collection [PDF]
Lecture 27 (Dec 7): X-Ray IV: Phasing by Isomorphous Replacement [PDF]
Lecture 28 (Dec 12): X-Ray V: Phasing by Molecular Replacement [PDF]
Problem Set 1 [PDF] Answers [PDF]
Problem Set 2 [PDF] Answers [PDF]
Problem Set 3 [PDF] Answers [PDF]
Exam 1 Questions from 2005 [PDF]
Exam 2 Questions from 2005 [PDF]
Exam 2 Answer Key from 2006 [PDF]
Useful Web Sites for Protein Sequence and Structure Analysis [PDF]
Measuring the Conformational Stability of a Protein,
C. N. Pace, B. A. Shirley and J. A. Thomson,
from Protein Structure: A Practical Approach,
edited by T. Creighton, pg 311-330, Oxford University Press, 1987
[PDF]
Mutant Sequences as Probes of Protein Folding Mechanisms,
C. R. Matthews and M. R. Hurle, Bioessays, 6, 254-257 (1987)
[PDF]
The Protein Folding "Speed Limit", J. Kubelka, J. Hofrichter and
W. A. Eaton,
Current Opinion in Structural Biology, 14, 76-88 (2004)
[PDF]
The Interactions of Matter with Light I: The Classical Electron Theory
of Optics,
from Quantum Chemistry, by W. Kauzmann, pg 546-585, Academic
Press, 1957
[PDF]
Overview and Study Guide for Protein NMR Lectures [PDF]
Introduction to NMR, from Biomolecular NMR Spectroscopy,
by J. N. S. Evans, Ch 1, pg 3-54, Oxford University Press, 1995
[PDF]
Product Operator Formalism & Vector Model,
from A Handbook of Nuclear Magnetic Resonance, 2nd Edition,
by R. Freeman, pg 185-194 & 328-333, Addison-Wesley Longman, 1997
[PDF]
Polarization Transfer,
from A Handbook of Nuclear Magnetic Resonance, 2nd Edition,
by R. Freeman, pg 178-184, Addison-Wesley Longman, 1997
[PDF]
Two-Dimensional Spectroscopy,
from A Handbook of Nuclear Magnetic Resonance, 2nd Edition,
by R. Freeman, pg 318-326, Addison-Wesley Longman, 1997
[PDF]
Correlation Spectroscopy,
from A Handbook of Nuclear Magnetic Resonance, 2nd Edition,
by R. Freeman, pg 76-83, Addison-Wesley Longman, 1997
[PDF]
X-Ray Diffraction, from Principles of Physical Biochemistry,
by K. E. van Holde, W. C. Johnson and P. S. Ho, pg 242-311,
Prentice-Hall, Inc., 1998
[PDF]
The hkl Manual, by D. Gewirth [PDF]
Software Information [TEXT]
KineMage [DIR]
RasMol [DIR]