Protein Data Bank File : 1ps1a Title : ANTIBIOTIC BIOSYNTHESIS 23-MAR-97 1PS1 Number of Amino Acid Residues : 304 Amino Acid Sequence : 1 2 3 4 5 6 7 8 9 10 0 GLN ASP VAL ASP PHE HIS ILE PRO LEU PRO 10 GLY ARG GLN SER PRO ASP HIS ALA ARG ALA 20 GLU ALA GLU GLN LEU ALA TRP PRO ARG SER 30 LEU GLY LEU ILE ARG SER ASP ALA ALA ALA 40 GLU ARG HIS LEU ARG GLY GLY TYR ALA ASP 50 LEU ALA SER ARG PHE TYR PRO HIS ALA THR 60 GLY ALA ASP LEU ASP LEU GLY VAL ASP LEU 70 MET SER TRP PHE PHE LEU PHE ASP ASP LEU 80 PHE ASP GLY PRO ARG GLY GLU ASN PRO GLU 90 ASP THR LYS GLN LEU THR ASP GLN VAL ALA 100 ALA ALA LEU ASP GLY PRO LEU PRO ASP THR 110 ALA PRO PRO ILE ALA HIS GLY PHE ALA ASP 120 ILE TRP ARG ARG THR CYS GLU GLY MET THR 130 PRO ALA TRP CYS ALA ARG SER ALA ARG HIS 140 TRP ARG ASN TYR PHE ASP GLY TYR VAL ASP 150 GLU ALA GLU SER ARG SER ALA ALA GLN TYR 160 LEU ALA MET ARG ARG HIS THR ILE GLY VAL 170 GLN PRO THR VAL ASP LEU ALA GLU ARG ALA 180 GLY ARG PHE GLU VAL PRO HIS ARG VAL PHE 190 ASP SER ALA VAL MET SER ALA MET LEU GLN 200 ILE ALA VAL ASP VAL ASN LEU LEU LEU ASN 210 ASP ILE ALA SER LEU GLU LYS GLU GLU ALA 220 ARG GLY GLU GLN ASN ASN MET VAL MET ILE 230 LEU ARG ARG GLU HIS GLY TRP SER LYS SER 240 ARG SER VAL SER HIS MET GLN ASN GLU VAL 250 ARG ALA ARG LEU GLU GLN TYR LEU LEU LEU 260 GLU SER CYS LEU PRO LYS VAL GLY GLU ILE 270 TYR GLN LEU ASP THR ALA GLU ARG GLU ALA 280 LEU GLU ARG TYR ARG THR ASP ALA VAL ARG 290 THR VAL ILE ARG GLY SER TYR ASP TRP HIS 300 ARG SER SER GLY Main and Side Chain Dihedral Angles : Residue Type Phi Psi Omega Chi 1 Chi 2 Chi 3 Chi 4 1 GLN 0.0 163.9 -179.9 -166.7 84.2 166.4 2 ASP 14.9 76.7 176.8 60.5 84.4 3 VAL -126.3 132.1 -177.9 167.2 4 ASP -63.3 136.8 178.8 -77.9 -49.6 5 PHE -144.5 154.9 -179.6 -78.0 -65.4 6 HIS -94.1 86.1 -178.7 178.3 -147.0 7 ILE -122.5 83.3 -179.1 -49.1 -46.0 8 PRO -76.1 60.7 179.4 36.7 -42.9 9 LEU -134.7 151.3 -179.6 -52.2 176.9 10 PRO -68.8 117.9 178.4 32.6 -41.4 11 GLY -68.1 137.7 179.6 12 ARG -144.3 164.0 -179.4 -50.0 156.5 55.9 -168.2 13 GLN -167.7 136.2 -177.1 -170.4 -159.4 113.6 14 SER -55.8 125.1 179.1 168.1 15 PRO -55.2 -26.3 -179.9 18.9 -37.6 16 ASP -87.3 11.9 -175.7 -164.3 29.1 17 HIS -58.4 -41.9 -178.1 76.5 -49.4 18 ALA -61.8 -46.6 179.4 19 ARG -61.3 -33.1 -179.1 166.7 -138.4 130.8 -84.5 20 ALA -68.9 -41.5 179.1 21 GLU -69.4 -32.6 178.7 -173.0 146.8 -83.5 22 ALA -66.5 -51.5 -179.5 23 GLU -86.0 7.1 -179.5 -81.7 121.6 -86.8 24 GLN -40.4 -43.7 -174.0 170.3 171.2 -174.4 25 LEU -77.7 -27.0 -178.6 -57.8 162.6 26 ALA -50.6 -41.6 -177.8 27 TRP -66.9 -60.0 -179.5 -176.7 67.5 28 PRO -60.6 -27.2 178.8 31.6 -37.5 29 ARG -68.4 -65.2 -177.4 -93.4 -166.9 179.0 -80.6 30 SER -50.8 -10.4 -179.7 80.3 31 LEU -107.9 8.5 178.9 -81.0 -62.8 32 GLY 70.2 17.8 -178.4 33 LEU -81.6 -21.9 177.8 -61.7 80.6 34 ILE -129.5 120.5 -177.9 -62.7 170.8 35 ARG -104.1 -55.1 178.1 -39.9 -140.8 68.9 147.7 36 SER -89.5 160.9 -179.5 67.5 37 ASP -67.0 -23.4 178.7 -58.8 5.6 38 ALA -81.9 -22.3 -179.7 39 ALA -78.9 -39.9 172.6 40 ALA -53.5 -50.3 -179.7 41 GLU -71.4 -29.3 178.8 170.2 73.4 24.7 42 ARG -68.2 -26.7 -179.9 -142.2 -169.7 69.8 112.6 43 HIS -74.6 -58.5 174.7 -162.6 58.5 44 LEU -41.7 -39.0 180.0 -66.1 -160.3 45 ARG -82.9 4.9 175.5 41.5 -174.5 89.7 167.2 46 GLY -84.7 -26.7 178.7 47 GLY 70.5 60.8 -176.6 48 TYR -91.5 -28.2 178.6 -54.5 -40.1 49 ALA -75.0 -21.4 179.9 50 ASP -73.6 -48.7 178.9 -164.6 63.7 51 LEU -59.0 -41.7 179.8 -172.1 51.4 52 ALA -59.7 -48.1 -179.2 53 SER -63.7 -7.8 176.4 74.9 54 ARG -107.5 -26.9 178.0 -59.4 173.9 178.7 -74.2 55 PHE -78.7 -34.0 -179.7 -83.4 -20.4 56 TYR -116.8 51.4 -179.9 -48.4 -44.5 57 PRO -56.4 -29.2 180.0 12.4 -27.9 58 HIS -79.7 -1.0 -175.4 54.6 -83.3 59 ALA -98.5 162.0 -179.6 60 THR -159.0 143.5 177.3 -88.3 61 GLY 70.8 -132.3 -179.0 62 ALA -60.8 -33.6 178.2 63 ASP -64.0 -37.4 177.9 -65.0 -19.3 64 LEU -70.2 -42.8 175.5 -177.9 44.3 65 ASP -51.6 -48.8 178.6 -70.9 -28.6 66 LEU -53.9 -33.9 -179.7 179.1 55.7 67 GLY -74.7 -39.8 179.4 68 VAL -58.5 -51.3 176.9 166.1 69 ASP -56.6 -42.3 178.4 -58.9 -17.8 70 LEU -61.9 -45.0 -179.3 174.8 67.9 71 MET -61.4 -45.8 175.8 -63.4 -47.3 -74.5 72 SER -56.2 -61.6 -179.5 -60.9 73 TRP -49.6 -36.7 180.0 -172.9 97.2 74 PHE -56.9 -51.5 -177.7 -100.2 -51.6 75 PHE -73.0 -36.7 173.8 -69.0 79.0 76 LEU -59.5 -49.4 177.9 -75.7 -173.7 77 PHE -61.4 -41.5 -177.5 166.6 -88.8 78 ASP -60.7 -33.2 179.5 -166.6 32.8 79 ASP -57.0 -42.9 179.9 -98.5 8.6 80 LEU -59.6 -2.7 179.8 -47.9 178.8 81 PHE -118.9 8.4 177.3 -58.5 86.1 82 ASP -79.3 -21.8 -179.8 -83.2 -56.6 83 GLY -76.7 -163.3 179.4 84 PRO -66.4 -30.9 179.0 -23.1 39.1 85 ARG -51.5 -19.3 -178.5 172.8 -171.0 -70.3 127.3 86 GLY -80.7 -13.7 -179.4 87 GLU -110.8 18.1 179.6 -45.9 117.2 -80.1 88 ASN -133.0 99.7 179.8 179.6 -80.8 89 PRO -38.5 -30.0 -177.2 -39.8 43.9 90 GLU -83.8 -22.7 179.5 -162.7 -135.1 81.4 91 ASP -89.1 -31.3 176.1 -57.4 -56.8 92 THR -63.8 -63.0 179.8 -61.0 93 LYS -53.1 -41.0 177.0 -175.3 151.8 168.9 72.4 94 GLN -48.1 -49.6 -179.0 151.2 65.4 -102.7 95 LEU -75.4 -53.9 175.2 -171.9 50.8 96 THR -34.8 -58.0 -176.9 -84.5 97 ASP -58.6 -31.9 179.2 -62.6 -0.3 98 GLN -75.4 -30.8 178.1 -52.7 -174.8 66.4 99 VAL -80.9 -56.8 179.8 176.4 100 ALA -54.0 -21.5 180.0 101 ALA -59.7 -29.1 -177.4 102 ALA -59.9 -24.9 -179.7 103 LEU -67.9 -20.0 -176.8 -61.4 168.8 104 ASP -102.9 -10.5 -179.5 -49.4 -22.5 105 GLY 160.4 -177.2 -179.5 106 PRO -60.1 141.9 -179.9 35.3 -43.8 107 LEU -89.5 138.9 179.6 -70.2 -171.9 108 PRO -66.7 138.8 -178.6 29.9 -41.1 109 ASP -46.7 -24.3 -177.7 -53.0 -16.4 110 THR -80.8 12.5 -179.5 63.7 111 ALA -84.6 146.7 -179.8 112 PRO -55.5 164.9 -179.1 19.9 -31.2 113 PRO -72.1 -29.5 178.3 -13.4 35.8 114 ILE -63.3 -21.2 178.3 -169.0 64.3 115 ALA -90.3 -31.7 177.8 116 HIS -74.3 -27.1 -178.8 -81.9 79.1 117 GLY -69.6 -46.0 178.0 118 PHE -58.7 -45.1 179.5 179.6 88.5 119 ALA -60.9 -41.2 179.5 120 ASP -59.3 -39.1 179.3 -175.7 43.5 121 ILE -64.6 -56.0 179.7 -74.9 168.4 122 TRP -59.7 -38.3 179.1 -178.3 -117.0 123 ARG -57.6 -32.4 -179.3 -177.7 -164.7 56.3 94.5 124 ARG -88.9 -29.0 179.0 -76.4 -177.3 -60.8 145.5 125 THR -64.3 -40.2 -176.9 -57.7 126 CYS -85.8 -38.0 -179.6 -168.8 127 GLU -46.0 118.5 178.6 -154.6 95.3 59.1 128 GLY 97.7 -12.1 179.3 129 MET -97.1 176.6 -178.0 -54.2 -71.7 -80.3 130 THR -90.9 150.7 -179.7 61.6 131 PRO -45.0 -43.2 -177.5 -33.4 45.5 132 ALA -70.9 -31.4 -178.7 133 TRP -70.2 -45.7 179.1 174.8 80.2 134 CYS -53.3 -48.2 179.8 -151.8 135 ALA -65.2 -32.7 179.9 136 ARG -70.7 -33.5 179.9 -170.2 -177.1 66.1 -151.3 137 SER -68.8 -45.9 178.1 -61.7 138 ALA -55.7 -39.7 178.1 139 ARG -59.9 -40.4 -176.2 171.0 -162.3 123.7 -139.8 140 HIS -68.3 -42.5 176.3 -67.5 154.3 141 TRP -60.5 -50.4 176.7 -92.5 134.3 142 ARG -56.0 -31.4 179.5 -63.2 -165.0 -166.1 86.1 143 ASN -78.6 -27.4 179.0 -45.5 114.9 144 TYR -60.2 -54.5 177.6 168.0 66.9 145 PHE -56.7 -52.0 179.4 -70.1 -47.0 146 ASP -62.2 -19.8 -179.6 -65.6 -17.0 147 GLY -67.0 -41.2 179.4 148 TYR -63.8 -43.0 179.6 -83.7 48.9 149 VAL -62.1 -48.1 178.8 177.9 150 ASP -66.9 -10.6 179.6 -78.3 68.3 151 GLU -88.1 -44.2 178.3 -161.0 152.9 86.2 152 ALA -59.3 -26.1 179.4 153 GLU -61.9 -39.0 -176.8 -172.6 84.9 17.0 154 SER -58.8 -1.6 -177.9 -54.3 155 ARG 110.0 -60.5 78.3 -100.3 39.1 -106.3 96.5 156 SER 76.9 104.0 179.3 -164.5 157 ALA -69.9 -54.0 -179.9 158 ALA -58.6 -21.6 178.6 159 GLN -86.8 -37.4 179.9 -173.9 -134.6 152.7 160 TYR -63.4 -52.0 179.9 168.9 67.9 161 LEU -57.1 -40.0 -179.8 -96.4 -167.9 162 ALA -49.6 -55.3 -179.5 163 MET -75.0 -36.9 -179.9 -82.1 -164.6 -133.0 164 ARG -60.7 -32.5 -179.9 -93.9 -94.0 76.4 -174.6 165 ARG -57.6 -19.5 -179.4 -70.8 171.7 165.3 167.1 166 HIS -95.6 -42.8 -178.3 -65.9 -70.6 167 THR -72.2 -21.3 -179.3 48.0 168 ILE -64.4 -27.3 179.3 -169.6 68.9 169 GLY 83.5 5.4 -177.2 170 VAL -57.1 -54.8 -179.0 178.0 171 GLN -55.7 -51.9 179.7 -166.1 62.8 46.5 172 PRO -64.1 -19.5 -179.2 -27.5 43.4 173 THR -69.3 -58.1 176.5 -70.8 174 VAL -53.9 -41.5 -178.9 162.8 175 ASP -56.7 -38.2 -177.5 -62.0 -29.8 176 LEU -64.5 -28.3 178.3 -141.1 -112.2 177 ALA -59.9 -38.6 174.8 178 GLU -62.7 -57.4 -179.8 -53.7 -176.5 67.1 179 ARG -51.7 -46.6 179.3 163.2 72.5 -129.5 -109.6 180 ALA -64.5 -42.6 177.9 181 GLY -73.2 -19.9 -178.0 182 ARG 65.0 45.4 177.7 -58.0 167.2 172.4 -78.5 183 PHE -146.8 168.3 176.4 78.0 84.5 184 GLU -144.7 121.0 175.8 -12.3 -173.5 -20.5 185 VAL -55.3 147.2 179.1 66.8 186 PRO -58.6 127.9 -179.3 -38.8 47.7 187 HIS -52.9 -37.1 179.9 -48.3 -121.0 188 ARG -68.7 -27.2 179.6 61.2 -175.2 -170.4 -72.9 189 VAL -86.7 -32.0 175.1 173.3 190 PHE -56.6 -43.4 -180.0 174.2 84.3 191 ASP -72.3 -4.5 -177.6 -64.9 -22.5 192 SER -66.0 142.8 178.8 68.3 193 ALA -54.6 -36.0 179.5 194 VAL -68.0 -52.6 179.8 166.4 195 MET -63.8 -41.3 179.2 -179.4 90.3 -85.6 196 SER -65.9 -22.8 177.6 63.6 197 ALA -76.1 -35.6 179.3 198 MET -69.2 -37.2 179.1 -72.6 162.1 69.5 199 LEU -65.8 -41.4 178.7 -70.3 170.6 200 GLN -63.8 -27.4 178.9 179.8 -135.5 92.2 201 ILE -74.9 -36.5 178.9 -77.0 -178.5 202 ALA -62.7 -43.6 178.5 203 VAL -62.5 -59.1 179.6 159.2 204 ASP -50.1 -48.1 -179.8 -84.6 -1.1 205 VAL -63.1 -39.6 179.2 158.8 206 ASN -63.0 -41.6 -178.9 -108.3 -99.6 207 LEU -79.3 -20.1 177.0 75.2 89.5 208 LEU -78.0 -39.1 179.2 -73.0 -171.8 209 LEU -64.0 -52.2 178.1 -112.3 33.4 210 ASN -52.2 -56.4 178.8 -174.4 95.3 211 ASP -59.0 -28.3 178.9 -91.2 18.7 212 ILE -77.8 -48.5 -179.9 -98.1 148.7 213 ALA -53.9 -44.5 -178.5 214 SER -94.4 23.3 -178.9 70.4 215 LEU -54.5 -50.5 -178.4 -168.3 35.9 216 GLU -70.6 -21.1 179.7 -49.3 93.9 56.2 217 LYS -80.0 -51.8 179.9 -149.9 -170.8 -174.5 -171.5 218 GLU -70.8 -18.5 179.3 -66.1 179.8 -21.3 219 GLU -71.2 -51.7 180.0 175.8 -176.9 59.7 220 ALA -57.3 -19.5 179.0 221 ARG -103.6 7.5 178.4 42.9 -168.2 43.2 141.4 222 GLY 81.7 1.9 -179.1 223 GLU -61.4 123.9 -179.0 -77.4 -173.5 39.1 224 GLN -102.6 3.1 179.2 56.6 -148.1 -143.4 225 ASN -98.9 53.4 179.2 68.3 142.2 226 ASN -129.2 137.6 -178.8 171.7 -58.6 227 MET -45.0 -42.1 -179.8 -163.8 63.5 75.7 228 VAL -62.4 -53.4 -179.7 -168.9 229 MET -58.1 -43.3 -179.1 -85.8 71.2 115.3 230 ILE -68.7 -35.9 -180.0 -56.0 171.4 231 LEU -67.7 -25.8 178.5 -73.8 -176.6 232 ARG -81.3 -28.4 -179.8 -54.8 177.5 51.5 -163.6 233 ARG -72.2 -67.5 -178.8 176.9 -175.7 -49.5 140.9 234 GLU -51.2 -51.7 -177.9 -166.2 -175.3 -16.9 235 HIS -89.6 -23.7 -177.2 -61.1 -74.7 236 GLY 73.7 57.7 -179.2 237 TRP -115.6 160.4 177.6 -89.0 -25.6 238 SER -78.6 145.4 -179.1 57.5 239 LYS -49.8 -19.0 178.9 174.8 168.6 162.4 -73.3 240 SER -88.2 -29.2 177.9 -169.2 241 ARG -74.0 -29.6 177.7 170.8 56.6 -168.2 135.3 242 SER -69.5 -34.5 179.7 -69.4 243 VAL -79.1 -39.9 178.0 177.4 244 SER -63.3 -49.8 179.9 54.1 245 HIS -52.6 -31.3 178.1 168.4 91.7 246 MET -74.0 -37.6 178.4 -70.2 -177.0 54.3 247 GLN -63.1 -36.6 178.6 -53.4 172.9 -79.1 248 ASN -66.6 -51.8 179.5 -72.5 -12.1 249 GLU -53.7 -41.0 178.9 -85.5 -53.1 -46.5 250 VAL -64.0 -52.7 -178.1 166.2 251 ARG -51.2 -46.1 -178.8 -169.5 168.9 -63.1 117.2 252 ALA -69.2 -31.9 -179.9 253 ARG -72.1 -37.7 178.5 -68.5 -167.9 -172.8 -55.1 254 LEU -65.9 -38.8 177.9 -107.8 -59.9 255 GLU -56.4 -59.5 -178.3 -57.0 -100.8 52.9 256 GLN -57.1 -37.2 178.7 -67.6 174.2 71.5 257 TYR -50.8 -49.3 -179.8 173.6 73.6 258 LEU -60.8 -37.3 178.1 -68.7 171.7 259 LEU -60.6 -54.2 179.1 -125.3 166.1 260 LEU -57.6 -41.5 179.8 -59.3 -175.1 261 GLU -55.9 -35.3 178.8 -116.1 -178.8 -16.0 262 SER -72.4 -25.4 177.6 76.2 263 CYS -79.4 -1.8 -177.0 -51.5 264 LEU -67.2 -36.7 -179.8 -123.7 24.7 265 PRO -64.0 -41.5 177.5 -28.6 46.2 266 LYS -65.9 -43.4 177.6 -127.9 -66.1 170.4 -151.9 267 VAL -59.3 -32.1 179.4 165.3 268 GLY -70.3 -34.6 177.6 269 GLU -62.3 -54.3 179.9 -80.2 175.0 27.3 270 ILE -47.9 -41.1 179.1 -70.1 166.3 271 TYR -90.9 8.8 178.5 -70.1 -82.2 272 GLN 42.3 58.7 -178.7 -41.6 -174.4 158.9 273 LEU -77.1 141.2 177.6 -65.4 -179.4 274 ASP -83.9 -175.4 179.7 70.7 65.8 275 THR -55.0 -54.7 -180.0 -55.5 276 ALA -58.8 -46.4 179.5 277 GLU -59.8 -49.5 -179.0 -59.8 179.3 -31.4 278 ARG -54.6 -30.6 179.8 -105.9 177.7 -61.2 147.2 279 GLU -80.0 -47.5 176.8 170.0 176.3 38.5 280 ALA -55.3 -41.8 176.9 281 LEU -66.2 -27.2 -178.9 169.1 63.5 282 GLU -72.4 -48.2 175.7 -173.1 51.7 -2.2 283 ARG -53.8 -46.4 179.9 -71.8 -92.3 -95.0 147.7 284 TYR -60.1 -34.6 -176.6 -165.8 77.7 285 ARG -75.0 -38.5 -177.6 175.4 -160.5 141.1 -117.6 286 THR -94.3 -31.7 -179.0 54.2 287 ASP -98.8 -12.5 179.9 -77.7 0.0 288 ALA -121.9 -57.6 -178.9 289 VAL -73.9 -36.3 -178.4 179.4 290 ARG -72.8 -46.4 179.6 -92.2 171.1 156.1 -141.0 291 THR -60.6 -36.6 179.2 50.3 292 VAL -69.8 -24.4 179.7 89.0 293 ILE -80.9 -57.9 -179.3 -61.5 -97.8 294 ARG -70.5 -47.0 179.4 160.5 128.5 -70.3 -125.5 295 GLY -44.8 -44.5 -179.6 296 SER -63.8 -46.3 177.6 52.8 297 TYR -59.7 -44.7 -179.3 173.6 86.3 298 ASP -62.4 -38.7 179.6 -83.4 -14.4 299 TRP -66.3 -52.5 177.4 -171.8 65.6 300 HIS -61.6 2.8 177.8 -80.3 131.7 301 ARG -107.9 51.1 178.8 -81.1 -150.0 158.5 -66.0 302 SER 157.0 -63.8 179.8 39.7 303 SER -91.3 164.9 179.1 -68.8 304 GLY 35.0 -80.9 0.0 Alpha Carbon Cartesian Coordinates : Residue Type X Y Z 1 GLN 35.468 62.549 29.504 2 ASP 32.585 62.510 32.086 3 VAL 32.360 59.234 34.049 4 ASP 31.281 59.455 37.728 5 PHE 33.740 59.131 40.596 6 HIS 34.070 59.233 44.347 7 ILE 36.716 61.986 45.062 8 PRO 36.153 63.669 48.469 9 LEU 38.833 66.364 48.321 10 PRO 38.401 70.157 47.826 11 GLY 38.643 71.299 44.217 12 ARG 41.073 74.248 43.933 13 GLN 42.759 76.093 41.122 14 SER 45.270 78.926 40.981 15 PRO 43.982 82.471 40.948 16 ASP 46.795 83.328 38.412 17 HIS 45.714 80.671 35.879 18 ALA 44.329 82.855 33.059 19 ARG 47.479 84.887 32.720 20 ALA 49.284 81.529 32.724 21 GLU 47.198 80.009 29.906 22 ALA 47.689 83.258 27.947 23 GLU 51.591 83.311 28.008 24 GLN 51.762 79.531 27.651 25 LEU 53.615 79.629 24.270 26 ALA 56.630 81.837 24.695 27 TRP 58.596 79.054 26.419 28 PRO 58.186 76.027 24.168 29 ARG 58.622 78.309 21.202 30 SER 61.946 79.910 22.236 31 LEU 63.388 76.401 22.821 32 GLY 62.419 75.181 19.358 33 LEU 59.928 72.733 20.678 34 ILE 57.027 74.195 18.643 35 ARG 57.972 75.700 15.238 36 SER 54.816 76.342 13.196 37 ASP 51.491 78.064 14.214 38 ALA 49.309 75.055 13.704 39 ALA 51.507 73.134 16.183 40 ALA 51.128 76.018 18.692 41 GLU 47.355 75.684 18.322 42 ARG 47.485 71.919 18.451 43 HIS 49.184 72.614 21.862 44 LEU 46.709 75.221 23.206 45 ARG 44.041 72.598 22.778 46 GLY 45.598 69.957 24.940 47 GLY 44.933 72.350 27.865 48 TYR 48.181 71.900 29.774 49 ALA 48.295 75.242 31.531 50 ASP 44.847 74.441 33.014 51 LEU 46.073 71.125 34.467 52 ALA 49.172 72.867 35.830 53 SER 46.946 75.369 37.554 54 ARG 45.073 72.565 39.412 55 PHE 48.115 70.485 40.327 56 TYR 49.768 73.704 41.545 57 PRO 46.814 75.739 43.016 58 HIS 49.198 77.179 45.518 59 ALA 51.511 78.692 42.849 60 THR 51.944 82.023 41.209 61 GLY 53.902 84.012 38.623 62 ALA 57.102 82.361 37.668 63 ASP 56.448 79.453 40.048 64 LEU 53.198 78.735 38.207 65 ASP 54.998 79.122 34.824 66 LEU 57.538 76.459 35.837 67 GLY 54.599 74.107 36.338 68 VAL 52.935 75.096 33.025 69 ASP 56.291 74.446 31.288 70 LEU 56.646 71.027 32.984 71 MET 53.152 70.132 31.791 72 SER 53.945 71.308 28.212 73 TRP 57.273 69.418 28.147 74 PHE 55.579 66.360 29.385 75 PHE 53.231 65.995 26.370 76 LEU 55.789 67.240 23.841 77 PHE 58.262 64.590 25.015 78 ASP 55.560 61.865 24.961 79 ASP 54.828 62.551 21.241 80 LEU 58.302 61.478 20.131 81 PHE 57.449 57.883 21.070 82 ASP 54.233 57.670 19.147 83 GLY 56.394 56.893 16.118 84 PRO 58.389 53.754 15.186 85 ARG 60.975 54.970 17.762 86 GLY 58.614 53.693 20.418 87 GLU 59.026 49.968 19.669 88 ASN 62.798 49.758 19.664 89 PRO 64.473 49.787 23.090 90 GLU 67.594 51.233 21.441 91 ASP 66.084 54.365 19.781 92 THR 64.136 55.156 22.887 93 LYS 67.296 54.798 25.080 94 GLN 69.157 56.574 22.365 95 LEU 66.920 59.614 23.116 96 THR 66.319 59.061 26.865 97 ASP 70.075 59.268 27.528 98 GLN 70.462 62.576 25.806 99 VAL 67.669 64.017 27.998 100 ALA 68.641 62.253 31.241 101 ALA 72.214 63.492 30.650 102 ALA 71.051 66.915 31.842 103 LEU 70.790 65.627 35.424 104 ASP 74.579 65.250 35.523 105 GLY 75.911 68.490 34.051 106 PRO 75.657 70.862 30.968 107 LEU 74.375 69.621 27.532 108 PRO 76.328 69.881 24.190 109 ASP 74.658 72.457 21.830 110 THR 74.059 69.489 19.507 111 ALA 71.453 67.956 21.800 112 PRO 67.820 67.838 20.494 113 PRO 65.495 70.610 21.624 114 ILE 63.378 68.266 23.797 115 ALA 66.591 67.793 25.840 116 HIS 67.500 71.480 26.155 117 GLY 63.926 72.119 27.218 118 PHE 64.159 69.565 29.954 119 ALA 67.378 71.089 31.140 120 ASP 65.853 74.572 31.331 121 ILE 63.102 73.074 33.512 122 TRP 65.437 71.141 35.828 123 ARG 67.819 74.078 36.157 124 ARG 64.800 75.860 37.575 125 THR 63.340 72.958 39.571 126 CYS 66.421 72.673 41.717 127 GLU 67.771 76.252 42.191 128 GLY 66.992 77.236 45.817 129 MET 66.106 73.812 47.165 130 THR 68.518 71.681 49.158 131 PRO 71.104 69.346 47.624 132 ALA 69.415 66.362 49.153 133 TRP 66.013 67.323 47.809 134 CYS 67.538 67.824 44.453 135 ALA 69.150 64.403 44.490 136 ARG 65.915 62.733 45.483 137 SER 64.156 64.398 42.510 138 ALA 66.863 63.293 40.070 139 ARG 66.509 59.687 41.259 140 HIS 62.756 59.977 40.346 141 TRP 63.427 61.414 36.871 142 ARG 65.830 58.562 36.093 143 ASN 63.144 55.940 36.802 144 TYR 60.759 57.933 34.682 145 PHE 63.224 57.647 31.776 146 ASP 63.949 54.033 32.433 147 GLY 60.197 53.574 32.465 148 TYR 60.027 54.506 28.810 149 VAL 62.916 52.157 27.943 150 ASP 61.361 49.151 29.744 151 GLU 58.127 49.952 27.842 152 ALA 59.718 49.920 24.334 153 GLU 60.948 46.474 25.294 154 SER 57.417 44.940 25.262 155 ARG 57.313 44.951 21.396 156 SER 48.178 40.838 32.881 157 ALA 46.924 43.793 34.991 158 ALA 49.548 43.499 37.754 159 GLN 52.198 43.482 35.021 160 TYR 50.646 46.474 33.186 161 LEU 50.414 48.669 36.298 162 ALA 53.960 47.666 37.043 163 MET 55.421 49.368 33.971 164 ARG 52.842 52.192 33.801 165 ARG 53.658 53.606 37.294 166 HIS 56.913 55.108 36.007 167 THR 55.933 56.511 32.578 168 ILE 52.867 58.334 33.919 169 GLY 54.980 61.194 35.383 170 VAL 53.169 61.537 38.758 171 GLN 56.149 61.578 41.106 172 PRO 58.173 64.195 39.337 173 THR 54.799 66.050 39.162 174 VAL 54.255 65.945 42.883 175 ASP 57.920 66.835 43.432 176 LEU 57.305 70.061 41.575 177 ALA 54.480 70.968 44.059 178 GLU 57.195 71.245 46.758 179 ARG 59.391 73.445 44.528 180 ALA 56.475 75.713 43.482 181 GLY 55.305 75.850 47.092 182 ARG 58.934 76.503 48.271 183 PHE 58.765 73.932 51.017 184 GLU 60.025 70.371 51.522 185 VAL 58.441 67.451 53.387 186 PRO 60.877 65.855 55.978 187 HIS 63.000 63.428 54.022 188 ARG 62.635 60.762 56.732 189 VAL 58.869 60.895 56.498 190 PHE 58.887 60.935 52.725 191 ASP 60.635 57.451 52.941 192 SER 57.889 56.125 55.315 193 ALA 55.732 53.077 54.544 194 VAL 52.574 55.184 55.160 195 MET 53.464 58.119 52.840 196 SER 54.824 55.988 50.064 197 ALA 51.494 54.105 50.271 198 MET 49.677 57.393 49.859 199 LEU 51.961 58.168 46.906 200 GLN 51.289 54.787 45.259 201 ILE 47.548 55.572 45.478 202 ALA 48.041 58.966 43.717 203 VAL 49.874 57.239 40.919 204 ASP 47.352 54.329 40.530 205 VAL 44.347 56.631 40.587 206 ASN 45.897 58.866 37.954 207 LEU 46.455 56.143 35.399 208 LEU 43.033 54.659 36.006 209 LEU 41.374 58.063 35.474 210 ASN 43.626 58.626 32.474 211 ASP 42.914 55.168 30.940 212 ILE 39.155 55.703 31.302 213 ALA 39.075 59.180 29.798 214 SER 40.988 58.177 26.626 215 LEU 39.177 54.862 26.102 216 GLU 37.569 55.556 22.676 217 LYS 40.751 57.009 21.162 218 GLU 43.313 54.175 21.766 219 GLU 40.579 51.618 20.915 220 ALA 40.013 52.898 17.373 221 ARG 43.766 52.359 16.690 222 GLY 43.927 48.780 18.032 223 GLU 46.009 49.354 21.215 224 GLN 45.777 46.488 23.700 225 ASN 47.929 48.044 26.388 226 ASN 45.045 49.870 28.044 227 MET 43.551 48.890 31.389 228 VAL 40.136 48.323 29.833 229 MET 41.439 46.077 27.047 230 ILE 43.707 44.186 29.416 231 LEU 40.888 43.687 31.956 232 ARG 38.671 41.941 29.350 233 ARG 41.638 39.757 28.404 234 GLU 42.807 38.549 31.811 235 HIS 39.240 38.093 33.152 236 GLY 37.165 37.542 30.024 237 TRP 34.804 40.431 30.787 238 SER 32.465 42.621 28.744 239 LYS 33.834 46.112 28.067 240 SER 31.284 47.563 30.554 241 ARG 32.255 45.245 33.488 242 SER 35.882 46.320 32.885 243 VAL 34.925 50.023 33.283 244 SER 32.723 49.636 36.351 245 HIS 35.406 47.530 38.096 246 MET 37.884 50.373 37.537 247 GLN 35.484 52.883 39.074 248 ASN 35.403 50.453 41.989 249 GLU 39.168 50.157 42.177 250 VAL 39.329 53.912 42.293 251 ARG 36.614 54.205 44.938 252 ALA 38.361 51.679 47.164 253 ARG 41.741 53.401 46.707 254 LEU 40.266 56.722 47.650 255 GLU 38.672 55.166 50.782 256 GLN 42.037 53.817 51.868 257 TYR 43.829 57.047 51.019 258 LEU 41.699 58.671 53.768 259 LEU 42.441 55.813 56.215 260 LEU 46.153 56.360 55.756 261 GLU 45.752 60.166 56.077 262 SER 44.384 59.622 59.624 263 CYS 47.500 57.577 60.543 264 LEU 49.582 60.629 59.743 265 PRO 49.600 62.323 63.182 266 LYS 50.860 59.130 64.788 267 VAL 53.438 58.849 61.980 268 GLY 54.727 62.343 62.814 269 GLU 55.167 61.234 66.449 270 ILE 57.160 58.130 65.403 271 TYR 59.578 60.414 63.496 272 GLN 59.607 62.958 66.324 273 LEU 58.852 65.781 64.019 274 ASP 59.203 69.246 65.372 275 THR 56.697 72.130 64.835 276 ALA 58.056 73.310 61.429 277 GLU 58.355 69.742 60.138 278 ARG 54.856 68.804 61.280 279 GLU 53.675 71.766 59.169 280 ALA 55.803 71.054 56.005 281 LEU 54.218 67.563 56.133 282 GLU 50.753 69.140 56.353 283 ARG 51.503 71.251 53.244 284 TYR 52.769 68.218 51.480 285 ARG 49.507 66.399 52.216 286 THR 47.194 69.158 51.125 287 ASP 49.279 71.016 48.516 288 ALA 51.142 68.227 46.748 289 VAL 49.540 64.830 47.191 290 ARG 45.933 66.008 47.255 291 THR 46.140 68.376 44.419 292 VAL 47.707 65.666 42.137 293 ILE 44.784 63.414 42.909 294 ARG 41.964 65.915 42.554 295 GLY 43.526 68.227 39.962 296 SER 43.551 65.434 37.377 297 TYR 39.874 64.507 37.939 298 ASP 38.683 68.151 37.779 299 TRP 40.669 68.535 34.543 300 HIS 39.294 65.463 32.802 301 ARG 35.943 67.248 33.447 302 SER 36.265 69.831 30.586 303 SER 39.906 70.080 29.118 304 GLY 42.195 67.442 27.492 Richards-Kundrot Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 S S S S S S/S S S S S/S 10 S S S S S H H H H H 20 H H H H H H H H H H 30 H H S S S S/H H H H H 40 H H H H H H 3/H H H H 50 H H H H H H H C C C 60 H H H H H H H H H H 70 H H H H H H H H H H 80 C C C T T T T H H H 90 H H H H H H H H H H 100 H/T T T T S S S S S C 110 C H H H H H H H H H 120 H H H H H H H C C H 130 H H H H H H H H H H 140 H H H H H H H H H H 150 H H H H C/X X/H H H H H 160 H H H H H/T T T T H H 170 H H H H H H H 3 3/T T 180 T T/S S S S S/H H H H H 190 H H/H H H H H H H H H 200 H H H H H H H H H H 210 H H H H H H H H H H 220 H H/S S S S H H H H H 230 H H H H H H C H H H 240 H H H H H H H H H H 250 H H H H H H H H H H 260 H H H H/H H H H H H H 270 H H C H H H H H H H 280 H H H H H H H H/H H H 290 H H H H H H H H H H 300 H/S S S S Kabsch-Sander Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 S 10 t T h H H H H 20 H H h T h H H H H H 30 h T t h H H H H 40 H H H H h T h H H H 50 H H H H H h T T t t 60 h H H H H H H H H H 70 H H H H H H H H H h 80 G g g G G G G h H H 90 H H H H H H H H H H 100 h G G g t t T T 110 t h H H H H H H H H 120 H H H H H H h T t h 130 H H H H H H H H H H 140 H H H H H H H H H H 150 H H h T t h H H H H 160 H H H H H H H h h H 170 H H H H H H H H H H 180 H h t h H H H H 190 h h H H H H H H H H 200 H H H H H H H H H H 210 H H H h H H H H H H 220 h T t h H H H H 230 H H H H H h h H H 240 H H H H H H H H H H 250 H H H H H H H H H H 260 H H H H H H H H H H 270 h T t h H H H H H H 280 H H H H H H H h H H 290 H H H H H H H H H h 300 T T t Buried Surface Area Percentages : Residue Type Buried Area % Buried % Polar Cover 1 GLN 78.3 52.7 77.7 2 ASP 30.7 27.8 77.2 3 VAL 77.0 64.8 63.9 4 ASP 7.4 6.7 87.0 5 PHE 160.3 96.1 38.5 6 HIS 81.6 54.3 62.7 7 ILE 142.9 99.6 33.3 8 PRO 78.6 63.1 55.2 9 LEU 146.1 98.9 38.9 10 PRO 51.3 41.2 70.8 11 GLY 25.2 72.5 73.8 12 ARG 126.8 60.7 63.3 13 GLN 116.4 78.3 67.3 14 SER 83.6 100.0 51.1 15 PRO 21.6 17.4 92.4 16 ASP 80.8 73.1 62.7 17 HIS 82.5 54.9 68.4 18 ALA 11.9 16.4 76.1 19 ARG 135.8 65.0 74.1 20 ALA 72.6 100.0 58.3 21 GLU 61.1 44.1 72.5 22 ALA 18.5 25.5 83.5 23 GLU 43.6 31.4 78.8 24 GLN 143.5 96.6 51.5 25 LEU 110.6 74.8 45.3 26 ALA 6.2 8.5 79.4 27 TRP 177.3 86.5 51.0 28 PRO 124.5 100.0 40.3 29 ARG 132.3 63.4 65.6 30 SER 17.3 20.7 77.9 31 LEU 110.5 74.8 61.9 32 GLY 25.9 74.4 74.4 33 LEU 140.1 94.8 39.1 34 ILE 138.0 96.2 43.2 35 ARG 34.4 16.5 84.4 36 SER 19.6 23.4 78.5 37 ASP 12.9 11.7 85.2 38 ALA 0.4 0.6 83.6 39 ALA 36.0 49.7 72.8 40 ALA 64.8 89.2 51.7 41 GLU 68.7 49.6 71.3 42 ARG 45.4 21.7 84.4 43 HIS 140.3 93.4 44.3 44 LEU 89.5 60.6 69.4 45 ARG 54.4 26.1 81.7 46 GLY 23.3 66.8 69.2 47 GLY 24.8 71.4 71.7 48 TYR 151.0 83.4 51.6 49 ALA 72.6 100.0 52.4 50 ASP 89.9 81.4 75.6 51 LEU 139.3 94.2 32.2 52 ALA 72.6 100.0 42.8 53 SER 83.6 100.0 47.6 54 ARG 170.8 81.8 65.8 55 PHE 156.4 93.8 39.8 56 TYR 180.0 99.5 33.2 57 PRO 121.6 97.7 59.3 58 HIS 131.9 87.8 59.6 59 ALA 71.2 98.1 53.2 60 THR 35.8 33.5 68.5 61 GLY 12.5 35.8 75.4 62 ALA 6.8 9.4 84.6 63 ASP 94.7 85.7 71.2 64 LEU 147.8 100.0 48.9 65 ASP 69.0 62.4 70.3 66 LEU 143.5 97.1 55.1 67 GLY 34.8 100.0 47.0 68 VAL 116.2 97.8 51.9 69 ASP 101.7 92.0 48.7 70 LEU 145.2 98.3 34.8 71 MET 151.3 94.9 37.7 72 SER 83.5 99.9 46.0 73 TRP 205.0 100.0 24.8 74 PHE 150.6 90.3 43.0 75 PHE 94.4 56.6 59.9 76 LEU 120.0 81.2 51.5 77 PHE 166.8 100.0 29.1 78 ASP 43.5 39.4 72.1 79 ASP 59.8 54.1 79.8 80 LEU 89.0 60.2 57.7 81 PHE 151.4 90.7 45.8 82 ASP 21.1 19.1 88.7 83 GLY 10.0 28.7 64.4 84 PRO 10.5 8.4 82.9 85 ARG 116.4 55.7 58.8 86 GLY 28.7 82.4 66.6 87 GLU 49.5 35.7 75.8 88 ASN 53.2 44.0 71.6 89 PRO 90.8 72.9 71.0 90 GLU 13.5 9.8 87.6 91 ASP 59.2 53.6 66.0 92 THR 105.7 98.9 47.5 93 LYS 65.7 37.9 73.6 94 GLN 46.9 31.6 80.7 95 LEU 136.9 92.6 44.0 96 THR 103.4 96.7 41.5 97 ASP 55.8 50.5 66.0 98 GLN 88.3 59.4 58.4 99 VAL 118.8 100.0 35.6 100 ALA 57.2 78.8 46.4 101 ALA 33.4 45.9 72.9 102 ALA 71.2 98.0 53.2 103 LEU 147.8 100.0 45.0 104 ASP 33.1 29.9 86.9 105 GLY 8.6 24.6 68.7 106 PRO 3.8 3.1 82.6 107 LEU 140.4 95.0 48.7 108 PRO 37.0 29.7 77.6 109 ASP 0.0 0.0 86.8 110 THR 2.9 2.7 79.4 111 ALA 67.8 93.4 52.2 112 PRO 87.4 70.2 51.1 113 PRO 64.5 51.8 71.1 114 ILE 133.5 93.0 28.2 115 ALA 72.6 100.0 44.8 116 HIS 96.1 64.0 63.3 117 GLY 34.8 100.0 43.7 118 PHE 166.5 99.8 29.5 119 ALA 46.3 63.7 55.0 120 ASP 77.5 70.2 68.0 121 ILE 142.3 99.1 42.9 122 TRP 179.9 87.7 47.0 123 ARG 66.1 31.6 81.8 124 ARG 156.6 75.0 63.8 125 THR 99.3 92.9 33.0 126 CYS 71.9 72.5 52.3 127 GLU 24.9 18.0 86.3 128 GLY 0.0 0.0 82.7 129 MET 149.6 93.8 53.5 130 THR 43.9 41.0 67.4 131 PRO 14.5 11.6 78.1 132 ALA 16.1 22.1 75.5 133 TRP 204.6 99.8 50.1 134 CYS 80.9 81.6 43.3 135 ALA 15.3 21.1 76.6 136 ARG 191.5 91.7 56.9 137 SER 80.7 96.5 47.7 138 ALA 63.5 87.4 53.0 139 ARG 85.6 41.0 73.7 140 HIS 139.7 93.0 60.7 141 TRP 195.7 95.5 22.8 142 ARG 109.8 52.6 67.8 143 ASN 58.6 48.5 69.3 144 TYR 177.5 98.1 38.3 145 PHE 165.5 99.2 30.5 146 ASP 36.9 33.4 72.0 147 GLY 29.6 85.1 59.9 148 TYR 165.8 91.6 47.1 149 VAL 94.9 79.9 55.6 150 ASP 31.2 28.2 68.0 151 GLU 79.9 57.6 69.3 152 ALA 69.4 95.5 64.8 153 GLU 37.8 27.2 74.5 154 SER 33.2 39.7 72.2 155 ARG 41.9 20.1 84.8 156 SER 40.4 48.3 75.2 157 ALA 51.8 71.4 56.7 158 ALA 0.0 0.0 81.7 159 GLN 46.2 31.1 74.1 160 TYR 157.8 87.2 47.0 161 LEU 122.7 83.0 53.5 162 ALA 29.6 40.8 72.6 163 MET 96.8 60.8 77.2 164 ARG 161.1 77.1 61.7 165 ARG 140.4 67.2 60.0 166 HIS 66.7 44.4 73.6 167 THR 106.5 99.6 60.5 168 ILE 127.7 89.0 63.5 169 GLY 33.9 97.5 48.6 170 VAL 112.8 94.9 40.4 171 GLN 117.0 78.7 45.2 172 PRO 118.3 95.0 44.1 173 THR 99.6 93.2 35.7 174 VAL 117.7 99.1 42.4 175 ASP 106.0 95.9 59.2 176 LEU 144.6 97.8 43.0 177 ALA 71.5 98.4 53.4 178 GLU 138.6 100.0 51.7 179 ARG 180.3 86.3 49.1 180 ALA 71.6 98.6 52.5 181 GLY 31.0 89.2 66.4 182 ARG 63.4 30.3 88.0 183 PHE 145.8 87.4 54.7 184 GLU 111.7 80.6 55.2 185 VAL 118.8 100.0 35.9 186 PRO 112.8 90.6 41.6 187 HIS 85.5 56.9 71.2 188 ARG 115.5 55.3 66.4 189 VAL 118.8 100.0 30.2 190 PHE 158.5 95.0 60.4 191 ASP 29.8 27.0 79.2 192 SER 78.3 93.7 59.9 193 ALA 0.0 0.0 87.7 194 VAL 84.9 71.5 44.8 195 MET 159.3 99.9 32.4 196 SER 35.8 42.8 70.9 197 ALA 38.8 53.4 67.6 198 MET 159.4 100.0 32.4 199 LEU 134.5 91.0 48.6 200 GLN 65.7 44.2 77.8 201 ILE 134.2 93.5 45.8 202 ALA 72.5 99.9 40.9 203 VAL 103.9 87.5 50.2 204 ASP 110.2 99.7 54.8 205 VAL 118.7 99.9 34.2 206 ASN 106.8 88.4 49.4 207 LEU 147.8 100.0 39.9 208 LEU 139.9 94.7 38.3 209 LEU 142.2 96.2 43.5 210 ASN 72.7 60.1 71.6 211 ASP 105.4 95.4 65.3 212 ILE 135.9 94.7 36.5 213 ALA 62.4 86.0 68.9 214 SER 43.7 52.3 75.3 215 LEU 137.8 93.3 51.6 216 GLU 27.2 19.6 84.1 217 LYS 36.9 21.3 85.1 218 GLU 90.7 65.4 71.4 219 GLU 74.1 53.5 61.9 220 ALA 9.2 12.6 86.5 221 ARG 82.8 39.6 76.1 222 GLY 0.0 0.1 85.4 223 GLU 76.1 54.9 73.1 224 GLN 29.9 20.1 83.1 225 ASN 43.9 36.3 65.6 226 ASN 120.7 99.8 52.2 227 MET 152.0 95.3 25.3 228 VAL 118.5 99.8 33.6 229 MET 130.4 81.8 58.2 230 ILE 136.9 95.4 54.8 231 LEU 140.7 95.2 44.5 232 ARG 107.7 51.5 69.8 233 ARG 104.5 50.0 68.8 234 GLU 70.0 50.5 68.3 235 HIS 82.2 54.7 63.4 236 GLY 2.1 6.0 81.9 237 TRP 149.1 72.7 62.7 238 SER 17.3 20.6 77.0 239 LYS 95.0 54.8 66.4 240 SER 3.0 3.6 83.9 241 ARG 115.4 55.2 74.5 242 SER 83.6 100.0 41.7 243 VAL 90.4 76.1 46.4 244 SER 45.5 54.4 75.5 245 HIS 111.6 74.3 60.0 246 MET 158.2 99.3 35.2 247 GLN 111.5 75.0 55.1 248 ASN 59.7 49.4 80.8 249 GLU 83.5 60.3 65.1 250 VAL 118.8 100.0 33.5 251 ARG 113.9 54.5 73.2 252 ALA 27.0 37.2 75.1 253 ARG 155.2 74.3 60.3 254 LEU 147.7 100.0 32.9 255 GLU 47.9 34.6 65.8 256 GLN 65.2 43.9 62.1 257 TYR 181.0 100.0 33.6 258 LEU 88.0 59.5 68.5 259 LEU 33.6 22.7 75.4 260 LEU 107.0 72.4 47.9 261 GLU 128.8 92.9 52.3 262 SER 21.8 26.0 75.4 263 CYS 47.0 47.3 61.9 264 LEU 138.8 93.9 32.4 265 PRO 35.0 28.1 82.1 266 LYS 49.7 28.7 76.6 267 VAL 107.3 90.3 34.5 268 GLY 32.1 92.3 50.8 269 GLU 41.7 30.1 78.9 270 ILE 49.1 34.2 69.3 271 TYR 114.2 63.1 52.8 272 GLN 11.0 7.4 90.8 273 LEU 147.8 100.0 42.0 274 ASP 32.3 29.2 78.3 275 THR 7.5 7.0 86.3 276 ALA 10.1 13.9 81.3 277 GLU 97.2 70.2 62.9 278 ARG 85.8 41.1 73.1 279 GLU 24.7 17.8 76.8 280 ALA 54.0 74.4 57.0 281 LEU 137.1 92.8 35.9 282 GLU 56.4 40.7 74.9 283 ARG 131.6 63.0 58.5 284 TYR 181.0 100.0 32.9 285 ARG 161.5 77.3 61.3 286 THR 73.6 68.8 70.2 287 ASP 98.6 89.3 62.9 288 ALA 72.6 100.0 47.9 289 VAL 118.8 100.0 35.5 290 ARG 173.7 83.1 53.2 291 THR 100.8 94.3 63.5 292 VAL 116.1 97.8 39.4 293 ILE 143.3 99.9 38.5 294 ARG 165.5 79.2 60.9 295 GLY 33.9 97.4 55.2 296 SER 78.3 93.7 53.8 297 TYR 155.8 86.1 60.8 298 ASP 91.4 82.7 58.9 299 TRP 189.3 92.3 52.2 300 HIS 122.4 81.5 57.3 301 ARG 132.0 63.2 72.4 302 SER 28.8 34.5 90.3 303 SER 53.0 63.4 68.6 304 GLY 18.7 53.8 54.6