Protein Data Bank File : 1j8y Title : SIGNALING PROTEIN 23-MAY-01 1J8Y Number of Amino Acid Residues : 291 Amino Acid Sequence : 1 2 3 4 5 6 7 8 9 10 0 LEU LEU ASP ASN LEU ARG ASP THR VAL ARG 10 LYS PHE LEU THR GLY SER SER SER TYR ASP 20 LYS ALA VAL GLU ASP PHE ILE LYS GLU LEU 30 GLN LYS SER LEU ILE SER ALA ASP VAL ASN 40 VAL LYS LEU VAL PHE SER LEU THR ASN LYS 50 ILE LYS GLU ARG LEU LYS ASN GLU LYS PRO 60 PRO THR TYR ILE GLU ARG ARG GLU TRP PHE 70 ILE LYS ILE VAL TYR ASP GLU LEU SER ASN 80 LEU PHE GLY GLY ASP LYS GLU PRO LYS VAL 90 ILE PRO ASP LYS ILE PRO TYR VAL ILE MET 100 LEU VAL GLY VAL GLN GLY THR THR ALA GLY 110 LYS LEU ALA TYR PHE TYR LYS LYS LYS GLY 120 PHE LYS VAL GLY LEU VAL GLY ALA ASP VAL 130 TYR ARG PRO ALA ALA LEU GLU GLN LEU GLN 140 GLN LEU GLY GLN GLN ILE GLY VAL PRO VAL 150 TYR GLY GLU PRO GLY GLU LYS ASP VAL VAL 160 GLY ILE ALA LYS ARG GLY VAL GLU LYS PHE 170 LEU SER GLU LYS MET GLU ILE ILE ILE VAL 180 ASP THR ALA GLY ARG HIS GLY TYR GLY GLU 190 GLU ALA ALA LEU LEU GLU GLU MET LYS ASN 200 ILE TYR GLU ALA ILE LYS PRO ASP GLU VAL 210 THR LEU VAL ILE ASP ALA SER ILE GLY GLN 220 LYS ALA TYR ASP LEU ALA SER LYS PHE ASN 230 GLN ALA SER LYS ILE GLY THR ILE ILE ILE 240 THR LYS MET ASP GLY THR ALA LYS GLY GLY 250 GLY ALA LEU SER ALA VAL ALA ALA THR GLY 260 ALA THR ILE LYS PHE ILE GLY THR GLY GLU 270 LYS ILE ASP GLU LEU GLU VAL PHE ASN PRO 280 ARG ARG PHE VAL ALA ARG LEU HIS HIS HIS 290 HIS Main and Side Chain Dihedral Angles : Residue Type Phi Psi Omega Chi 1 Chi 2 Chi 3 Chi 4 1 LEU 0.0 -55.7 -179.6 164.6 57.2 2 LEU -66.0 -35.4 179.4 -72.2 -175.1 3 ASP -67.3 -33.3 179.1 -67.5 -35.2 4 ASN -74.0 -36.9 178.5 -65.0 -44.2 5 LEU -63.4 -31.2 -179.6 -78.4 158.6 6 ARG -58.3 -42.0 -179.6 -178.2 -174.7 171.2 -172.0 7 ASP -73.8 -33.8 179.3 -52.8 -53.3 8 THR -67.0 -42.2 179.3 -48.5 9 VAL -60.2 -47.7 -180.0 169.6 10 ARG -55.3 -49.8 -179.5 174.9 -178.5 176.5 179.6 11 LYS -60.5 -37.5 179.5 -64.4 175.3 -179.3 57.3 12 PHE -66.7 -49.7 -179.0 176.9 74.8 13 LEU -60.6 -36.5 179.0 -67.8 176.7 14 THR -76.5 72.6 -179.2 59.2 15 GLY -27.6 85.2 -179.9 16 SER -83.3 -74.2 -179.2 -177.6 17 SER -95.8 -162.2 179.2 61.1 18 SER -64.8 152.5 179.6 70.5 19 TYR -53.6 -54.1 -178.9 179.7 72.9 20 ASP -53.0 -48.1 179.5 -77.1 7.5 21 LYS -68.0 -36.7 179.8 173.5 -177.8 172.3 51.0 22 ALA -60.1 -43.3 179.2 23 VAL -64.1 -46.3 -179.9 167.9 24 GLU -57.5 -51.0 179.4 -76.3 168.1 33.9 25 ASP -56.9 -47.3 -179.5 -78.0 172.7 26 PHE -59.6 -47.9 -179.3 -176.3 88.8 27 ILE -60.8 -40.7 179.5 -69.3 -62.6 28 LYS -62.4 -42.5 -180.0 -68.4 -178.6 -174.3 -177.8 29 GLU -67.7 -38.6 178.6 -72.6 -50.2 -49.3 30 LEU -61.2 -49.5 -180.0 170.0 59.1 31 GLN -57.4 -47.0 179.6 -73.3 160.4 163.3 32 LYS -62.0 -43.0 179.5 -71.8 156.6 66.8 177.0 33 SER -65.4 -40.5 178.9 -66.3 34 LEU -66.1 -42.7 179.2 -70.1 171.7 35 ILE -60.0 -46.0 179.2 -72.0 179.4 36 SER -61.4 -27.3 -179.6 -63.8 37 ALA -84.3 7.0 179.7 38 ASP 67.9 29.4 178.2 -161.9 38.0 39 VAL -79.8 134.2 179.6 178.0 40 ASN -50.5 129.9 -177.5 -168.1 81.2 41 VAL -57.1 -33.6 178.1 70.3 42 LYS -61.0 -42.0 179.1 -156.7 -70.9 174.0 57.0 43 LEU -68.2 -36.0 179.5 -60.2 -172.8 44 VAL -63.7 -45.7 -179.8 176.3 45 PHE -62.0 -48.2 179.7 179.3 63.6 46 SER -62.6 -41.0 -179.6 -64.9 47 LEU -60.3 -52.2 -179.4 172.9 65.1 48 THR -67.3 -31.1 178.9 51.2 49 ASN -71.6 -36.0 179.4 -76.0 -23.7 50 LYS -66.9 -41.8 178.9 -177.5 178.7 -179.3 -178.9 51 ILE -60.2 -46.2 -180.0 -71.8 173.2 52 LYS -63.5 -36.3 -180.0 -75.6 -175.0 -174.7 -66.7 53 GLU -66.6 -54.4 179.9 -177.8 78.0 -50.6 54 ARG -54.1 -37.6 -179.2 -71.3 -164.7 57.1 -165.8 55 LEU -64.8 -23.0 -180.0 -153.9 -74.5 56 LYS -95.2 -23.7 -179.4 74.3 164.2 63.4 62.8 57 ASN -100.9 -15.0 -178.6 -52.6 -56.1 58 GLU -121.5 97.6 179.7 -65.7 169.5 47.0 59 LYS -72.0 158.3 179.9 79.0 -62.4 -179.2 -59.4 60 PRO -65.1 143.8 179.4 -22.5 38.0 61 PRO -66.1 157.4 179.8 -29.1 42.8 62 THR -54.7 144.1 -179.5 54.1 63 TYR 81.4 -14.2 179.8 -73.7 95.9 64 ILE -96.3 121.7 -179.9 -61.3 -57.9 65 GLU -60.6 150.3 -179.8 -58.7 167.6 53.5 66 ARG -61.1 -40.1 -178.9 -63.0 176.1 76.0 -158.5 67 ARG -72.6 -36.8 177.8 -63.9 -160.9 -175.0 -151.6 68 GLU -65.3 -40.3 -179.2 -75.6 -70.5 -27.5 69 TRP -63.1 -42.7 179.3 -175.7 -121.3 70 PHE -56.8 -49.7 -179.4 172.9 72.1 71 ILE -62.9 -38.0 179.1 -64.8 -53.9 72 LYS -59.5 -43.7 178.9 -172.6 -83.4 179.9 175.2 73 ILE -65.5 -40.2 178.8 -75.6 177.6 74 VAL -60.5 -45.4 179.3 169.1 75 TYR -63.0 -42.6 -179.9 -67.5 -31.5 76 ASP -57.2 -46.7 -178.1 -73.3 -23.8 77 GLU -72.6 -28.7 178.0 -64.1 -44.6 -42.2 78 LEU -67.5 -42.2 178.8 -81.0 171.6 79 SER -59.4 -43.3 179.2 171.1 80 ASN -62.3 -45.0 178.8 -75.6 163.7 81 LEU -51.8 -34.3 -179.6 175.0 69.6 82 PHE -94.9 8.2 178.6 -61.8 -38.5 83 GLY 124.8 -17.4 179.6 84 GLY 86.4 171.6 -179.8 85 ASP -63.9 106.8 179.8 179.5 -175.0 86 LYS -156.9 125.7 179.5 -166.5 -173.6 73.0 62.0 87 GLU -103.4 113.5 -179.6 -164.2 69.3 -148.7 88 PRO -72.1 158.5 178.8 35.8 -44.1 89 LYS -88.0 108.5 -178.0 176.9 -179.9 175.1 58.1 90 VAL -104.8 -12.9 179.1 -60.3 91 ILE -105.9 112.0 -180.0 -57.6 -58.3 92 PRO -68.1 143.4 178.6 33.4 -43.6 93 ASP -107.9 18.4 178.6 53.8 48.4 94 LYS -131.3 121.8 178.7 175.8 174.1 179.3 -68.3 95 ILE -122.6 133.8 0.0 -87.3 61.1 96 PRO -76.2 160.1 -179.8 35.7 -45.0 97 TYR -122.5 119.2 -179.7 -163.1 76.8 98 VAL -104.3 122.2 -179.7 179.4 99 ILE -113.0 126.5 179.3 -59.4 174.1 100 MET -109.4 116.7 178.2 174.9 -176.4 -93.8 101 LEU -91.7 137.2 179.3 -66.4 179.2 102 VAL -140.3 169.2 179.5 -58.6 103 GLY 156.6 174.3 179.2 104 VAL -74.4 159.9 179.4 -55.4 105 GLN -55.5 113.8 179.0 -73.4 -70.0 -55.8 106 GLY 91.8 101.0 140.9 107 THR 87.2 -42.9 179.8 -63.4 108 THR -58.4 -40.6 179.1 -60.2 109 ALA -63.9 -42.7 178.8 110 GLY -65.5 -42.6 -179.9 111 LYS -63.7 -39.8 -179.9 -67.3 -165.3 -166.5 -179.6 112 LEU -65.2 -42.8 179.6 -165.7 52.7 113 ALA -66.0 -35.8 178.5 114 TYR -64.2 -46.9 179.3 177.9 74.5 115 PHE -53.7 -47.7 -178.4 175.5 82.9 116 TYR -74.0 -32.4 178.2 -74.9 -65.1 117 LYS -64.7 -40.0 -179.8 -173.5 171.0 -168.4 -60.4 118 LYS -63.5 -27.5 179.4 -169.0 -179.0 -65.6 -149.1 119 LYS -80.5 -3.1 178.6 -59.1 -51.9 178.0 -179.8 120 GLY 97.2 9.0 -179.3 121 PHE -86.5 153.6 176.9 -69.5 -78.2 122 LYS -91.3 107.8 -177.5 -67.4 -68.8 -176.8 174.8 123 VAL -107.7 148.0 178.0 -173.1 124 GLY -131.0 135.1 179.7 125 LEU -109.4 134.6 178.2 -82.7 165.0 126 VAL -115.7 117.0 -179.9 177.8 127 GLY -89.4 94.2 -179.1 128 ALA -113.9 28.6 178.0 129 ASP -101.6 82.8 -177.0 -178.7 9.5 130 VAL -77.6 -32.3 -180.0 -57.8 131 TYR -50.4 -54.0 178.4 -56.6 160.9 132 ARG -78.6 112.9 -179.9 -55.6 170.8 57.9 67.4 133 PRO -66.6 -39.9 -179.9 33.0 -44.2 134 ALA -69.5 -19.0 -179.5 135 ALA -49.2 -60.3 -179.4 136 LEU -52.8 -49.0 179.8 -179.5 60.3 137 GLU -57.2 -48.8 179.5 -56.9 -173.2 -54.6 138 GLN -56.0 -50.9 -179.4 -68.6 169.7 51.6 139 LEU -54.9 -50.1 179.7 -137.5 -150.6 140 GLN -56.7 -34.5 179.2 -80.5 162.8 158.4 141 GLN -68.9 -46.9 178.6 -77.8 -173.8 58.1 142 LEU -61.1 -42.6 -179.6 -70.5 175.5 143 GLY -61.1 -42.0 179.3 144 GLN -66.5 -40.5 -179.3 178.8 70.8 55.8 145 GLN -65.1 -35.6 -178.9 -169.9 71.7 58.2 146 ILE -104.6 3.6 179.4 65.0 179.0 147 GLY 68.3 40.5 178.8 148 VAL -124.2 132.3 -179.8 165.6 149 PRO -63.8 136.3 179.6 -21.0 38.2 150 VAL -122.1 121.8 177.8 171.2 151 TYR -99.1 136.5 180.0 -179.7 81.9 152 GLY -164.2 159.1 -180.0 153 GLU -127.3 96.0 -179.8 -75.6 163.3 35.6 154 PRO -47.3 125.8 178.9 -34.1 45.0 155 GLY 79.5 -14.3 180.0 156 GLU -70.4 138.2 -179.7 176.3 62.0 65.7 157 LYS -117.7 -1.2 178.1 -67.2 175.2 -61.2 178.1 158 ASP -81.4 83.5 -179.0 176.7 -1.9 159 VAL -50.3 -44.9 -179.7 58.1 160 VAL -63.9 -37.9 179.7 173.5 161 GLY -68.1 -38.8 179.6 162 ILE -66.0 -49.6 -179.7 -60.3 175.7 163 ALA -58.1 -45.9 -179.5 164 LYS -63.4 -50.0 179.8 -174.7 160.2 54.9 59.4 165 ARG -64.6 -41.3 179.5 -72.8 -172.4 -74.1 -78.9 166 GLY -62.2 -48.4 -180.0 167 VAL -63.7 -43.8 179.0 168.0 168 GLU -57.8 -42.6 179.8 -172.5 175.5 -49.3 169 LYS -63.1 -47.3 -179.0 174.6 -162.8 165.6 62.3 170 PHE -71.0 -30.9 177.5 -73.3 -46.9 171 LEU -65.6 -35.0 179.8 -75.4 177.5 172 SER -70.4 -36.7 -179.9 -64.1 173 GLU -78.0 2.0 179.3 -62.7 177.2 178.9 174 LYS 60.5 41.7 177.7 -56.4 -50.9 -59.2 -63.4 175 MET -68.2 152.3 -179.7 -75.7 -61.6 108.4 176 GLU -91.9 -38.5 178.5 -65.8 169.2 152.8 177 ILE -129.1 128.3 -179.8 -62.4 -178.3 178 ILE -122.5 121.8 -179.2 -58.7 175.3 179 ILE -110.6 122.2 -179.3 -58.5 171.3 180 VAL -105.9 117.9 -179.7 -171.3 181 ASP -92.5 120.7 179.7 -166.5 32.4 182 THR -135.2 165.3 179.5 81.9 183 ALA -121.8 -108.1 -179.4 184 GLY 159.9 154.6 -179.3 185 ARG -88.7 -5.0 -178.6 -76.8 -65.7 -160.9 175.9 186 HIS -121.6 162.9 179.7 -75.3 60.4 187 GLY -112.1 -170.3 179.9 188 TYR -65.6 129.5 -178.7 -65.0 -74.4 189 GLY 111.7 -8.7 -179.6 190 GLU -126.2 28.8 -178.7 -52.4 170.6 -66.3 191 GLU -45.4 -46.7 -179.4 -62.7 80.1 -163.7 192 ALA -51.5 -51.8 -179.7 193 ALA -69.1 -33.6 -180.0 194 LEU -62.3 -53.8 179.9 -178.9 54.8 195 LEU -59.9 -43.8 179.0 -66.1 -177.7 196 GLU -51.4 -52.7 -179.8 172.2 -172.0 -59.7 197 GLU -58.0 -25.8 179.9 169.4 173.3 47.4 198 MET -69.6 -41.4 -178.0 -87.0 179.1 57.8 199 LYS -43.8 -45.4 -178.9 -160.0 153.3 54.7 -175.7 200 ASN -61.2 -46.3 179.6 -66.4 56.6 201 ILE -63.1 -48.8 -179.7 -41.5 173.2 202 TYR -52.1 -45.8 -179.9 172.8 -86.0 203 GLU -62.2 -38.0 -178.9 -82.8 -64.6 -53.9 204 ALA -73.9 -30.8 -177.9 205 ILE -101.7 -23.6 179.8 -98.6 52.2 206 LYS 45.5 60.1 -179.8 -61.9 -63.4 177.7 59.0 207 PRO -68.3 157.9 178.7 35.1 -43.3 208 ASP -81.9 -22.5 -179.7 -62.3 -76.6 209 GLU -150.7 143.0 178.6 -179.7 173.8 -10.0 210 VAL -120.8 126.1 -177.9 177.8 211 THR -121.9 119.1 179.7 -60.3 212 LEU -86.7 125.1 179.5 171.0 68.7 213 VAL -98.5 126.5 -179.5 -177.7 214 ILE -123.5 127.5 178.0 -64.7 -179.6 215 ASP -77.6 123.2 -179.3 -178.7 153.3 216 ALA -51.7 -22.5 -178.2 217 SER -66.6 -15.3 179.6 65.5 218 ILE -72.3 -19.5 -179.9 -173.2 65.0 219 GLY 59.6 -143.1 -178.6 220 GLN -64.9 -13.6 179.6 66.9 176.0 120.5 221 LYS -69.6 -7.8 179.2 -70.6 -173.1 -172.6 63.8 222 ALA -73.0 -16.1 -178.5 223 TYR -47.5 -61.2 -178.6 -178.9 74.9 224 ASP -50.2 -53.8 -179.8 -82.1 168.6 225 LEU -62.9 -47.1 -179.5 179.9 52.9 226 ALA -59.9 -42.3 -179.4 227 SER -59.3 -56.0 -179.7 -177.8 228 LYS -63.5 -37.0 179.9 -61.7 -57.8 174.9 -178.2 229 PHE -62.0 -52.2 -177.7 171.2 74.1 230 ASN -61.2 -31.9 178.8 -165.5 48.1 231 GLN -76.9 -29.8 -178.7 -79.4 176.6 164.2 232 ALA -61.5 -22.7 179.4 233 SER -155.6 157.2 179.7 75.4 234 LYS -88.9 -8.5 -178.7 174.7 -163.3 -67.3 -176.9 235 ILE -113.6 27.4 -178.8 59.0 172.8 236 GLY -94.5 139.5 177.5 237 THR -137.1 166.4 -177.7 55.8 238 ILE -130.5 145.7 176.6 -63.3 -179.5 239 ILE -124.1 128.5 177.8 -72.0 172.7 240 ILE -104.7 119.4 -178.4 -57.5 -53.4 241 THR -104.1 170.1 178.8 63.8 242 LYS 48.4 46.5 179.5 -60.4 -178.5 -177.7 180.0 243 MET -64.2 -25.3 -179.3 -77.1 -73.5 -73.5 244 ASP -94.1 -8.7 179.9 -70.8 -175.1 245 GLY -94.4 16.6 -179.7 246 THR -155.2 162.0 178.5 56.4 247 ALA -101.3 -0.3 -177.7 248 LYS -99.5 12.7 179.5 -54.8 -175.0 177.2 64.8 249 GLY -57.0 -39.1 179.4 250 GLY -61.7 -37.2 179.7 251 GLY -68.7 -41.4 179.3 252 ALA -65.0 -47.1 -179.5 253 LEU -62.8 -49.0 -179.1 -79.2 50.6 254 SER -64.4 -36.2 179.8 60.9 255 ALA -66.8 -44.5 179.5 256 VAL -68.4 -41.6 179.3 170.4 257 ALA -60.8 -32.2 -180.0 258 ALA -65.2 -15.7 178.8 259 THR -94.4 -8.3 -179.2 74.2 260 GLY 76.4 3.7 -179.2 261 ALA -64.6 156.3 180.0 262 THR -88.2 109.5 177.0 -59.8 263 ILE -90.9 105.4 -177.8 -67.1 -178.6 264 LYS -81.8 -42.2 -179.4 -178.1 171.5 -65.0 -176.6 265 PHE -133.5 159.3 177.0 -61.2 -84.6 266 ILE -130.1 134.0 179.5 -156.5 169.5 267 GLY -94.4 117.4 -178.7 268 THR -90.0 -73.2 -179.9 50.8 269 GLY -102.5 -171.3 -179.7 270 GLU -89.9 -5.5 179.8 -63.2 178.3 -61.7 271 LYS -75.0 146.0 -177.7 -66.6 -168.6 175.0 -178.4 272 ILE -53.0 -28.0 -179.1 -166.8 68.5 273 ASP -96.0 4.1 -179.1 64.5 -59.7 274 GLU -89.0 66.6 177.7 -68.2 -178.8 -70.1 275 LEU -139.8 124.8 -178.4 -174.3 68.1 276 GLU -126.8 148.0 178.1 -48.9 170.0 179.7 277 VAL -68.7 131.2 -176.8 174.9 278 PHE -100.0 130.2 176.7 -177.6 77.2 279 ASN -143.4 112.1 -179.9 178.7 166.4 280 PRO -44.0 -42.1 -179.9 -32.6 43.2 281 ARG -62.0 -45.4 -179.7 176.7 -178.8 65.5 72.5 282 ARG -71.7 -35.1 179.4 -64.1 -166.8 -71.4 95.5 283 PHE -60.1 -45.2 -179.7 -175.0 68.8 284 VAL -75.1 -27.5 -179.2 175.1 285 ALA -67.4 -24.4 -179.0 286 ARG -50.9 -38.4 -178.7 -175.0 -166.0 68.2 -172.7 287 LEU -93.2 12.4 -178.5 62.5 155.3 288 HIS -52.5 131.9 -179.1 -165.1 -66.0 289 HIS -66.0 -12.5 -179.7 58.8 -76.3 290 HIS -95.8 16.9 177.6 -83.9 156.8 291 HIS -136.8 -123.0 0.0 61.7 -169.9 Alpha Carbon Cartesian Coordinates : Residue Type X Y Z 1 LEU 23.559 53.403 29.967 2 LEU 23.513 49.819 31.242 3 ASP 27.268 49.796 31.793 4 ASN 26.859 52.948 33.886 5 LEU 23.915 51.407 35.766 6 ARG 26.242 48.520 36.572 7 ASP 28.436 50.753 38.720 8 THR 25.452 52.388 40.412 9 VAL 24.067 48.959 41.315 10 ARG 27.446 47.924 42.718 11 LYS 27.698 51.010 44.921 12 PHE 24.178 50.364 46.152 13 LEU 24.718 46.681 46.980 14 THR 27.893 47.305 48.962 15 GLY 25.785 48.528 51.880 16 SER 27.496 51.835 52.623 17 SER 24.941 54.155 54.266 18 SER 21.379 53.722 55.544 19 TYR 18.998 51.777 53.338 20 ASP 16.768 54.817 52.736 21 LYS 19.621 57.098 51.706 22 ALA 21.165 54.342 49.602 23 VAL 17.878 54.067 47.714 24 GLU 17.610 57.845 47.339 25 ASP 21.142 58.124 46.012 26 PHE 20.515 55.231 43.623 27 ILE 17.276 56.642 42.252 28 LYS 18.860 60.053 41.613 29 GLU 21.699 58.458 39.671 30 LEU 19.271 56.275 37.716 31 GLN 17.166 59.333 36.841 32 LYS 20.263 61.273 35.802 33 SER 21.625 58.395 33.671 34 LEU 18.274 57.894 31.960 35 ILE 17.998 61.628 31.263 36 SER 21.511 61.523 29.825 37 ALA 20.409 58.555 27.658 38 ASP 17.750 60.817 26.141 39 VAL 14.877 58.911 27.730 40 ASN 11.701 61.014 27.797 41 VAL 11.541 62.637 31.245 42 LYS 7.914 61.567 31.643 43 LEU 9.071 57.938 31.270 44 VAL 11.932 58.491 33.718 45 PHE 9.527 59.919 36.301 46 SER 6.978 57.123 35.857 47 LEU 9.696 54.482 36.074 48 THR 11.136 55.659 39.370 49 ASN 7.686 56.218 40.855 50 LYS 6.656 52.690 39.893 51 ILE 9.854 51.360 41.469 52 LYS 9.154 53.293 44.687 53 GLU 5.571 52.034 44.726 54 ARG 6.436 48.362 44.262 55 LEU 9.046 48.788 46.995 56 LYS 6.345 49.829 49.483 57 ASN 3.769 47.179 48.566 58 GLU 6.116 44.222 47.975 59 LYS 8.304 43.198 50.897 60 PRO 11.279 40.988 50.058 61 PRO 10.427 37.276 50.011 62 THR 11.902 35.422 53.001 63 TYR 15.662 34.788 52.700 64 ILE 16.021 37.628 50.186 65 GLU 17.998 40.658 51.366 66 ARG 16.333 44.082 51.166 67 ARG 19.010 45.505 48.878 68 GLU 18.977 42.510 46.533 69 TRP 15.191 42.793 46.388 70 PHE 15.380 46.492 45.496 71 ILE 17.698 45.794 42.567 72 LYS 15.553 42.905 41.347 73 ILE 12.630 45.328 41.141 74 VAL 14.868 47.881 39.388 75 TYR 15.907 45.314 36.723 76 ASP 12.284 44.237 36.230 77 GLU 11.167 47.796 35.571 78 LEU 14.121 48.608 33.308 79 SER 13.125 45.637 31.177 80 ASN 9.563 47.008 31.083 81 LEU 10.862 50.465 30.136 82 PHE 12.369 48.812 27.054 83 GLY 9.337 46.731 26.115 84 GLY 9.220 43.959 28.680 85 ASP 10.028 40.260 28.555 86 LYS 9.387 39.284 24.945 87 GLU 11.130 36.957 22.511 88 PRO 10.372 37.929 18.883 89 LYS 9.721 35.450 16.072 90 VAL 12.807 35.669 13.882 91 ILE 12.489 32.475 11.856 92 PRO 9.738 32.664 9.199 93 ASP 7.472 29.643 8.705 94 LYS 6.432 30.845 5.252 95 ILE 8.651 30.430 2.193 96 PRO 9.313 32.453 0.252 97 TYR 9.483 35.300 2.775 98 VAL 9.816 38.889 1.522 99 ILE 11.160 41.535 3.898 100 MET 11.001 45.192 3.007 101 LEU 13.371 47.458 4.912 102 VAL 12.426 51.135 5.132 103 GLY 13.528 54.193 7.056 104 VAL 14.855 57.743 6.892 105 GLN 18.023 58.539 4.944 106 GLY 20.873 57.088 6.989 107 THR 24.648 47.523 6.284 108 THR 21.513 46.442 8.126 109 ALA 20.229 44.757 4.960 110 GLY 23.528 42.919 4.626 111 LYS 23.509 41.960 8.307 112 LEU 19.945 40.681 8.069 113 ALA 20.788 38.556 5.015 114 TYR 23.888 37.239 6.820 115 PHE 21.761 36.314 9.827 116 TYR 19.392 34.288 7.679 117 LYS 22.110 32.690 5.564 118 LYS 23.741 31.475 8.788 119 LYS 20.389 29.912 9.680 120 GLY 20.600 27.922 6.444 121 PHE 18.249 29.961 4.239 122 LYS 18.666 30.789 0.557 123 VAL 18.662 34.585 0.656 124 GLY 18.441 37.183 -2.089 125 LEU 19.150 40.907 -1.658 126 VAL 17.499 43.705 -3.648 127 GLY 19.255 47.064 -3.621 128 ALA 16.462 49.606 -4.064 129 ASP 17.981 52.531 -2.152 130 VAL 18.564 54.734 -5.207 131 TYR 18.837 58.123 -3.532 132 ARG 22.193 57.079 -2.089 133 PRO 24.333 56.295 -5.169 134 ALA 26.980 54.467 -3.145 135 ALA 24.229 52.335 -1.584 136 LEU 24.026 49.791 -4.423 137 GLU 27.811 49.422 -4.705 138 GLN 28.088 48.937 -0.954 139 LEU 25.294 46.355 -0.983 140 GLN 26.937 44.446 -3.820 141 GLN 30.146 44.435 -1.757 142 LEU 28.451 43.068 1.359 143 GLY 26.685 40.516 -0.832 144 GLN 29.918 39.360 -2.461 145 GLN 31.543 39.203 0.968 146 ILE 28.835 36.987 2.490 147 GLY 27.930 34.926 -0.564 148 VAL 24.383 36.245 -1.013 149 PRO 23.043 37.334 -4.438 150 VAL 22.382 41.049 -4.864 151 TYR 20.001 42.426 -7.482 152 GLY 20.388 46.060 -8.479 153 GLU 20.107 48.481 -11.402 154 PRO 22.986 50.991 -11.659 155 GLY 21.732 54.546 -12.103 156 GLU 18.071 53.539 -11.979 157 LYS 15.919 55.771 -9.768 158 ASP 12.538 54.074 -10.184 159 VAL 12.650 52.459 -6.731 160 VAL 9.340 50.661 -7.338 161 GLY 10.527 49.271 -10.666 162 ILE 13.757 47.964 -9.137 163 ALA 12.003 46.344 -6.174 164 LYS 9.425 44.694 -8.420 165 ARG 11.957 43.343 -10.916 166 GLY 14.320 42.294 -8.128 167 VAL 11.678 40.430 -6.137 168 GLU 10.298 38.853 -9.312 169 LYS 13.799 37.645 -10.216 170 PHE 14.440 36.070 -6.820 171 LEU 10.982 34.534 -6.609 172 SER 11.764 32.816 -9.920 173 GLU 15.104 31.561 -8.622 174 LYS 13.099 30.127 -5.731 175 MET 14.929 32.122 -3.055 176 GLU 13.599 31.473 0.464 177 ILE 14.148 34.901 2.004 178 ILE 14.202 38.091 -0.041 179 ILE 15.283 41.352 1.541 180 VAL 14.498 44.623 -0.208 181 ASP 16.553 47.605 0.858 182 THR 14.780 50.941 0.454 183 ALA 15.203 54.334 2.102 184 GLY 12.970 57.396 1.851 185 ARG 13.072 61.089 0.892 186 HIS 12.285 62.425 4.367 187 GLY 13.750 62.612 7.838 188 TYR 12.478 62.708 11.402 189 GLY 9.756 65.308 11.829 190 GLU 8.234 64.516 8.436 191 GLU 6.820 61.108 9.364 192 ALA 3.490 61.660 7.591 193 ALA 5.169 62.160 4.209 194 LEU 7.708 59.433 4.927 195 LEU 5.056 56.780 5.543 196 GLU 2.976 58.032 2.614 197 GLU 5.967 57.540 0.312 198 MET 6.348 53.953 1.602 199 LYS 2.900 52.826 0.444 200 ASN 3.698 52.730 -3.287 201 ILE 6.690 50.422 -2.921 202 TYR 4.767 48.244 -0.456 203 GLU 1.861 47.782 -2.873 204 ALA 4.123 46.649 -5.712 205 ILE 6.038 44.123 -3.625 206 LYS 3.415 43.010 -1.091 207 PRO 6.061 42.010 1.471 208 ASP 5.371 39.567 4.295 209 GLU 7.144 41.937 6.652 210 VAL 8.082 45.609 6.700 211 THR 10.971 46.583 8.938 212 LEU 11.690 50.147 9.915 213 VAL 15.389 50.695 10.588 214 ILE 16.158 53.325 13.200 215 ASP 19.597 54.688 14.056 216 ALA 19.886 54.713 17.865 217 SER 21.409 58.211 17.729 218 ILE 17.967 59.700 17.136 219 GLY 17.115 58.912 20.761 220 GLN 13.578 59.660 21.936 221 LYS 12.803 61.535 18.724 222 ALA 12.231 58.119 17.145 223 TYR 8.863 58.073 18.912 224 ASP 6.753 59.849 16.280 225 LEU 7.923 57.778 13.314 226 ALA 7.787 54.475 15.188 227 SER 4.298 55.246 16.487 228 LYS 2.818 56.085 13.098 229 PHE 4.743 53.256 11.422 230 ASN 3.505 50.549 13.773 231 GLN -0.108 51.653 13.455 232 ALA 0.246 51.768 9.661 233 SER 0.494 47.980 9.289 234 LYS -0.012 44.672 11.067 235 ILE 3.238 43.292 9.656 236 GLY 5.623 45.982 10.851 237 THR 8.731 45.392 12.939 238 ILE 11.658 47.561 13.964 239 ILE 15.430 47.239 14.074 240 ILE 17.445 49.701 16.141 241 THR 20.984 50.077 14.780 242 LYS 24.272 51.543 15.978 243 MET 23.432 51.075 19.645 244 ASP 27.113 51.420 20.559 245 GLY 27.811 54.527 18.505 246 THR 25.643 56.730 20.718 247 ALA 24.720 57.504 24.297 248 LYS 21.059 57.860 23.293 249 GLY 20.286 54.184 22.733 250 GLY 18.209 54.118 25.907 251 GLY 16.090 56.973 24.582 252 ALA 15.537 55.267 21.243 253 LEU 14.605 51.922 22.817 254 SER 12.302 53.423 25.427 255 ALA 10.697 55.693 22.833 256 VAL 10.039 52.761 20.505 257 ALA 8.897 50.529 23.356 258 ALA 6.370 53.242 24.316 259 THR 4.612 52.598 20.985 260 GLY 4.360 48.879 21.739 261 ALA 6.094 48.123 18.442 262 THR 8.062 44.920 18.004 263 ILE 11.828 45.526 18.095 264 LYS 13.068 42.289 16.537 265 PHE 16.806 42.990 16.238 266 ILE 19.299 45.459 17.590 267 GLY 22.434 46.414 15.651 268 THR 25.416 46.516 17.969 269 GLY 28.681 46.941 16.071 270 GLU 29.732 47.625 12.483 271 LYS 30.705 44.001 11.866 272 ILE 28.515 41.900 9.575 273 ASP 27.617 39.499 12.392 274 GLU 26.713 42.231 14.861 275 LEU 22.938 41.926 14.723 276 GLU 21.204 40.281 17.665 277 VAL 17.673 39.124 18.384 278 PHE 16.267 41.604 20.875 279 ASN 14.458 40.850 24.125 280 PRO 14.373 43.660 26.746 281 ARG 14.719 41.100 29.545 282 ARG 17.871 39.602 28.042 283 PHE 19.190 43.032 27.074 284 VAL 18.899 44.111 30.718 285 ALA 20.155 40.759 32.052 286 ARG 23.611 41.298 30.529 287 LEU 24.681 43.509 33.441 288 HIS 23.343 41.372 36.297 289 HIS 25.601 41.794 39.327 290 HIS 25.621 38.054 40.071 291 HIS 27.623 36.873 37.056 Richards-Kundrot Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 H H H H H H H H H H 10 H H H H/S S S S H H H 20 H H H H H H H H H H 30 H H H H H H H H C H 40 H H H H H H H H H H 50 H H H H H H H H S S 60 S S C C H H H H H H 70 H H H H H H H H H H 80 H H H S S S S S S S 90 S S S/S S S/P S/S S S S S 100 S S S S S C/X X/H H H H 110 H H H H H H H H H H/S 120 S S S S S S S S C C 130 C C C H H H H H H H 140 H H H H H H H/S S S S 150 S S S C S S S S/H H H 160 H H H H H H H H H H 170 H H H H/S S S S/S S S S 180 S S S S S S C C C H 190 H H H H H H H H H/H H 200 H H H H H H C S S S 210 S S S S S S C T T T 220 T H H H H H H H H H 230 H H 3 S S S S S S S 240 S S/T T T T C C H H H 250 H H H H H H H H H H/S 260 S S S S/S S S S S S C 270 C C C S S S S S S/H H 280 H H H H H H/S S S S/S S 290 S Kabsch-Sander Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 h H H H H H H H H H 10 H H H h S h H H 20 H H H H H H H H H H 30 H H H H H H h T t h 40 H H H H H H H H H H 50 H H H H H H H h 60 t T T t h H H H H H 70 H H H H H H H H H H 80 H h T t S 90 S S S S S E E E E 100 E E S h H H H 110 H H H H H H H H h T 120 t e E E E E E e 130 S h H H H H H H H H 140 H H H H H H h t e E 150 E t T T t h H H 160 H H H H H H H H H H 170 H H h T t e E E E E 180 E e S t T T h 190 H H H H H H H H H H 200 H H H H H h S E E 210 E E E E E e G G G G 220 G h H H H H H H H H 230 H H h T e E E E E E 240 E t T T t S h H H 250 H H H H H H H h T T 260 t e E E E E E e S S 270 t T T e E E E e h H 280 H H H H H h T t T T 290 t Buried Surface Area Percentages : Residue Type Buried Area % Buried % Polar Cover 1 LEU 134.6 91.0 43.5 2 LEU 143.7 97.2 36.6 3 ASP 27.6 25.0 80.8 4 ASN 34.7 28.7 83.0 5 LEU 146.2 98.9 30.1 6 ARG 57.6 27.6 79.6 7 ASP 46.9 42.5 78.5 8 THR 88.7 83.0 49.8 9 VAL 115.3 97.1 34.5 10 ARG 37.6 18.0 78.6 11 LYS 43.9 25.3 76.9 12 PHE 159.7 95.8 39.2 13 LEU 125.2 84.7 49.2 14 THR 24.7 23.1 78.4 15 GLY 21.2 61.0 79.3 16 SER 9.7 11.6 89.2 17 SER 47.5 56.8 66.7 18 SER 20.6 24.6 75.5 19 TYR 158.8 87.7 54.3 20 ASP 18.0 16.2 78.7 21 LYS 68.4 39.5 83.3 22 ALA 64.1 88.3 65.3 23 VAL 103.2 86.8 41.5 24 GLU 53.0 38.2 71.7 25 ASP 52.9 47.8 70.7 26 PHE 163.4 98.0 28.8 27 ILE 138.9 96.8 40.8 28 LYS 54.1 31.2 81.1 29 GLU 69.1 49.9 71.8 30 LEU 147.2 99.6 24.2 31 GLN 95.3 64.1 52.1 32 LYS 55.9 32.2 78.0 33 SER 62.1 74.2 61.1 34 LEU 147.8 100.0 24.4 35 ILE 54.5 38.0 67.5 36 SER 14.0 16.7 81.0 37 ALA 69.8 96.1 54.1 38 ASP 82.6 74.7 62.6 39 VAL 118.8 100.0 39.4 40 ASN 70.5 58.3 61.7 41 VAL 21.6 18.2 70.9 42 LYS 41.9 24.2 79.2 43 LEU 103.6 70.1 54.4 44 VAL 115.0 96.8 38.5 45 PHE 41.8 25.1 84.1 46 SER 39.6 47.3 63.6 47 LEU 137.7 93.2 37.9 48 THR 104.4 97.7 44.9 49 ASN 61.5 50.8 59.8 50 LYS 76.1 43.9 72.2 51 ILE 143.2 99.8 30.3 52 LYS 89.9 51.8 63.4 53 GLU 57.0 41.1 77.0 54 ARG 161.0 77.1 60.1 55 LEU 110.3 74.6 57.1 56 LYS 63.5 36.6 83.2 57 ASN 48.9 40.5 70.3 58 GLU 81.2 58.6 67.0 59 LYS 32.4 18.7 77.6 60 PRO 94.9 76.3 49.1 61 PRO 69.8 56.1 61.4 62 THR 1.1 1.0 82.7 63 TYR 0.0 0.0 88.4 64 ILE 73.0 50.9 63.3 65 GLU 19.0 13.7 80.4 66 ARG 69.8 33.4 65.6 67 ARG 169.8 81.3 52.9 68 GLU 101.3 73.1 58.9 69 TRP 176.3 86.0 45.2 70 PHE 165.8 99.4 26.7 71 ILE 143.5 100.0 31.6 72 LYS 79.3 45.7 69.1 73 ILE 143.5 100.0 47.6 74 VAL 118.3 99.6 25.8 75 TYR 158.2 87.4 43.9 76 ASP 69.3 62.8 71.9 77 GLU 135.4 97.7 49.5 78 LEU 146.3 99.0 24.4 79 SER 74.4 88.9 53.6 80 ASN 62.4 51.6 80.9 81 LEU 130.7 88.4 36.2 82 PHE 166.3 99.7 29.1 83 GLY 17.0 48.8 67.7 84 GLY 26.9 77.4 74.2 85 ASP 41.8 37.8 78.3 86 LYS 87.4 50.4 76.2 87 GLU 64.4 46.5 73.2 88 PRO 121.1 97.2 58.0 89 LYS 52.8 30.4 83.8 90 VAL 100.1 84.3 40.7 91 ILE 73.1 50.9 51.5 92 PRO 118.4 95.1 37.5 93 ASP 20.3 18.4 77.2 94 LYS 59.6 34.4 80.9 95 ILE 83.1 57.9 60.5 96 PRO 79.7 64.0 59.7 97 TYR 148.7 82.1 50.1 98 VAL 109.3 92.0 42.6 99 ILE 140.6 98.0 40.9 100 MET 159.3 99.9 32.0 101 LEU 145.9 98.7 41.0 102 VAL 118.4 99.7 41.5 103 GLY 30.5 87.7 58.3 104 VAL 109.7 92.3 53.4 105 GLN 98.3 66.1 62.2 106 GLY 2.8 8.1 74.0 107 THR 47.3 44.2 67.2 108 THR 91.2 85.3 33.6 109 ALA 71.2 98.1 43.8 110 GLY 34.8 100.0 37.0 111 LYS 163.9 94.5 49.7 112 LEU 144.9 98.0 27.9 113 ALA 72.6 100.0 34.7 114 TYR 127.7 70.6 49.4 115 PHE 144.2 86.4 40.0 116 TYR 178.4 98.6 27.7 117 LYS 93.5 53.9 73.4 118 LYS 63.2 36.4 75.1 119 LYS 94.4 54.4 55.8 120 GLY 1.3 3.6 84.0 121 PHE 139.1 83.4 42.8 122 LYS 38.0 21.9 77.5 123 VAL 118.8 100.0 39.3 124 GLY 34.8 100.0 34.8 125 LEU 147.8 100.0 31.7 126 VAL 118.8 100.0 40.0 127 GLY 32.5 93.4 49.9 128 ALA 72.6 100.0 44.2 129 ASP 98.5 89.2 55.7 130 VAL 105.4 88.7 51.8 131 TYR 138.8 76.7 67.2 132 ARG 109.8 52.6 76.0 133 PRO 18.8 15.1 84.4 134 ALA 31.2 42.9 73.4 135 ALA 62.5 86.0 69.5 136 LEU 124.6 84.3 58.1 137 GLU 34.2 24.6 80.7 138 GLN 68.7 46.2 71.7 139 LEU 139.3 94.2 42.3 140 GLN 80.1 53.9 59.6 141 GLN 26.7 18.0 77.7 142 LEU 104.0 70.4 54.7 143 GLY 34.8 100.0 54.5 144 GLN 5.9 4.0 88.8 145 GLN 20.9 14.0 80.7 146 ILE 133.0 92.7 40.2 147 GLY 1.8 5.3 77.4 148 VAL 117.6 99.0 37.6 149 PRO 61.0 49.0 67.1 150 VAL 113.9 95.9 48.9 151 TYR 138.3 76.4 47.7 152 GLY 34.8 100.0 50.1 153 GLU 108.3 78.1 53.3 154 PRO 35.7 28.7 78.4 155 GLY 0.0 0.0 85.9 156 GLU 83.5 60.3 67.6 157 LYS 28.7 16.5 82.3 158 ASP 39.6 35.9 74.2 159 VAL 93.1 78.3 46.3 160 VAL 78.4 66.0 49.6 161 GLY 30.7 88.3 72.7 162 ILE 142.0 99.0 51.0 163 ALA 72.6 100.0 34.3 164 LYS 80.7 46.5 70.9 165 ARG 114.5 54.8 75.4 166 GLY 34.8 100.0 43.8 167 VAL 110.2 92.8 34.1 168 GLU 31.3 22.6 75.7 169 LYS 84.1 48.5 66.7 170 PHE 166.4 99.7 38.5 171 LEU 83.8 56.7 56.5 172 SER 19.2 22.9 77.4 173 GLU 77.7 56.1 60.6 174 LYS 28.7 16.5 90.0 175 MET 133.1 83.5 52.6 176 GLU 89.1 64.3 52.3 177 ILE 143.5 100.0 25.5 178 ILE 143.5 100.0 36.1 179 ILE 143.5 100.0 33.1 180 VAL 118.8 100.0 31.7 181 ASP 81.3 73.6 50.0 182 THR 106.5 99.7 40.2 183 ALA 65.3 89.9 71.7 184 GLY 30.0 86.1 59.1 185 ARG 76.3 36.5 71.4 186 HIS 91.7 61.1 65.6 187 GLY 12.3 35.2 65.5 188 TYR 153.5 84.8 44.3 189 GLY 2.5 7.1 80.1 190 GLU 57.0 41.1 74.6 191 GLU 121.6 87.8 47.5 192 ALA 0.0 0.0 81.5 193 ALA 39.1 53.9 70.1 194 LEU 145.9 98.7 47.9 195 LEU 124.9 84.5 42.5 196 GLU 24.7 17.8 80.1 197 GLU 91.6 66.1 67.2 198 MET 138.6 87.0 39.9 199 LYS 40.7 23.5 78.0 200 ASN 21.9 18.1 73.9 201 ILE 131.2 91.4 36.8 202 TYR 120.2 66.4 48.4 203 GLU 52.4 37.8 68.2 204 ALA 53.0 73.1 57.6 205 ILE 140.6 98.0 36.3 206 LYS 59.8 34.5 80.0 207 PRO 124.5 100.0 39.9 208 ASP 83.7 75.8 57.5 209 GLU 131.0 94.5 55.4 210 VAL 116.7 98.2 32.2 211 THR 103.4 96.7 44.1 212 LEU 146.9 99.4 29.2 213 VAL 91.2 76.8 55.1 214 ILE 143.5 100.0 38.5 215 ASP 86.3 78.1 70.4 216 ALA 72.6 100.0 53.7 217 SER 44.1 52.7 66.6 218 ILE 114.8 80.0 49.6 219 GLY 34.8 100.0 59.6 220 GLN 98.5 66.3 70.0 221 LYS 38.3 22.1 78.0 222 ALA 72.6 100.0 40.6 223 TYR 87.1 48.1 70.3 224 ASP 33.3 30.1 72.7 225 LEU 147.4 99.8 31.6 226 ALA 72.6 100.0 40.8 227 SER 64.7 77.4 57.7 228 LYS 62.5 36.1 77.1 229 PHE 164.4 98.6 34.8 230 ASN 85.4 70.6 70.7 231 GLN 39.2 26.4 86.9 232 ALA 31.9 44.0 70.0 233 SER 58.1 69.5 64.0 234 LYS 0.0 0.0 88.2 235 ILE 89.8 62.6 67.0 236 GLY 34.8 100.0 64.5 237 THR 92.0 86.0 54.8 238 ILE 143.2 99.8 32.3 239 ILE 142.3 99.2 29.7 240 ILE 143.5 100.0 27.9 241 THR 93.5 87.5 49.6 242 LYS 54.1 31.2 82.8 243 MET 147.2 92.3 41.9 244 ASP 26.0 23.5 78.7 245 GLY 1.7 4.9 75.1 246 THR 82.2 76.9 66.6 247 ALA 5.2 7.1 84.1 248 LYS 80.8 46.6 76.4 249 GLY 31.1 89.5 57.8 250 GLY 33.4 95.9 41.9 251 GLY 34.8 100.0 63.8 252 ALA 72.6 100.0 47.6 253 LEU 147.3 99.7 24.6 254 SER 83.4 99.7 43.8 255 ALA 67.9 93.5 54.1 256 VAL 118.8 100.0 35.5 257 ALA 67.5 93.0 67.3 258 ALA 43.1 59.4 60.9 259 THR 98.3 91.9 56.6 260 GLY 0.0 0.0 87.8 261 ALA 71.6 98.6 62.3 262 THR 67.8 63.4 61.7 263 ILE 138.8 96.7 42.8 264 LYS 154.8 89.3 51.7 265 PHE 164.4 98.5 28.0 266 ILE 139.7 97.3 31.9 267 GLY 34.7 99.7 54.4 268 THR 80.7 75.5 65.0 269 GLY 20.2 57.9 74.1 270 GLU 0.0 0.0 84.5 271 LYS 24.9 14.4 86.8 272 ILE 104.9 73.1 45.3 273 ASP 51.9 47.0 62.8 274 GLU 90.7 65.4 69.9 275 LEU 145.1 98.2 37.9 276 GLU 47.5 34.3 74.0 277 VAL 94.6 79.6 52.7 278 PHE 161.5 96.8 37.4 279 ASN 120.1 99.3 56.6 280 PRO 118.7 95.4 52.7 281 ARG 94.2 45.1 72.2 282 ARG 122.2 58.5 75.6 283 PHE 123.2 73.8 43.1 284 VAL 115.2 97.0 38.3 285 ALA 29.7 40.9 75.0 286 ARG 80.6 38.6 75.0 287 LEU 140.4 95.0 45.1 288 HIS 91.6 61.0 61.6 289 HIS 120.9 80.5 56.4 290 HIS 49.2 32.8 80.1 291 HIS 58.7 39.1 81.8