Protein Data Bank File : 1i49a Title : SIGNALING PROTEIN 20-FEB-01 1I49 Number of Amino Acid Residues : 201 Amino Acid Sequence : 1 2 3 4 5 6 7 8 9 10 0 SER ARG THR VAL ASP LEU GLU LEU GLU LEU 10 GLN ILE GLU LEU LEU ARG GLU THR LYS ARG 20 LYS TYR GLU SER VAL LEU GLN LEU GLY ARG 30 ALA LEU THR ALA HIS LEU TYR SER LEU LEU 40 GLN THR GLN HIS ALA LEU GLY ASP ALA PHE 50 ALA ASP LEU SER GLN LYS SER PRO GLU LEU 60 GLN GLU GLU PHE GLY TYR ASN ALA GLU THR 70 GLN LYS LEU LEU CYS LYS ASN GLY GLU THR 80 LEU LEU GLY ALA VAL ASN PHE PHE VAL SER 90 SER ILE ASN THR LEU VAL THR LYS THR MET 100 GLU ASP THR LEU MET THR VAL LYS GLN TYR 110 GLU ALA ALA ARG LEU GLU TYR ASP ALA TYR 120 ARG THR ASP LEU GLU GLU LEU SER LEU GLY 130 PRO ARG ASP ALA GLY THR ARG GLY ARG LEU 140 GLU SER ALA GLN ALA THR PHE GLN ALA HIS 150 ARG ASP LYS TYR GLU LYS LEU ARG GLY ASP 160 VAL ALA ILE LYS LEU LYS PHE LEU GLU GLU 170 ASN LYS ILE LYS VAL MET HIS LYS GLN LEU 180 LEU LEU PHE HIS ASN ALA VAL SER ALA TYR 190 PHE ALA GLY ASN GLN LYS GLN LEU GLU GLN 200 THR Main and Side Chain Dihedral Angles : Residue Type Phi Psi Omega Chi 1 Chi 2 Chi 3 Chi 4 1 SER 0.0 121.5 -179.4 55.5 2 ARG -149.4 136.7 178.9 146.4 -170.7 110.2 73.8 3 THR -51.7 126.4 -179.1 -70.6 4 VAL -127.3 144.5 178.6 176.2 5 ASP -129.2 64.5 -178.5 -62.7 8.4 6 LEU -24.0 -51.1 179.7 -67.5 -167.0 7 GLU -64.2 -60.8 179.5 -98.0 114.6 100.3 8 LEU -53.5 -53.0 -178.9 -110.0 -157.5 9 GLU -50.2 -49.8 178.6 -72.6 -170.1 21.0 10 LEU -60.8 -48.3 178.1 -67.5 -178.9 11 GLN -52.1 -47.2 179.5 -168.8 102.3 -76.4 12 ILE -65.0 -39.7 180.0 -72.5 171.3 13 GLU -59.2 -46.2 179.3 179.4 53.1 -71.4 14 LEU -55.0 -49.7 -179.8 -81.9 -88.3 15 LEU -56.8 -37.7 179.9 166.0 73.6 16 ARG -69.2 -44.0 178.6 -82.8 177.2 171.7 140.8 17 GLU -66.5 -43.9 179.0 -154.6 -179.6 72.5 18 THR -54.3 -54.1 -179.1 -78.4 19 LYS -53.9 -43.4 178.6 -179.0 146.9 175.6 -60.4 20 ARG -62.9 -49.1 179.0 -89.5 171.4 -65.8 155.9 21 LYS -55.7 -45.9 -179.7 -59.0 -54.0 -164.1 57.0 22 TYR -66.8 -20.2 -179.9 -82.6 42.3 23 GLU -82.6 -35.3 179.8 -78.9 168.2 -35.0 24 SER -74.7 -17.9 178.0 62.8 25 VAL -80.7 -35.5 178.9 159.8 26 LEU -67.3 -33.1 178.0 -147.8 50.7 27 GLN -66.9 -49.7 -179.8 -76.9 -51.2 81.9 28 LEU -62.2 -33.2 178.9 -64.2 166.6 29 GLY -67.4 -41.7 -179.7 30 ARG -69.2 -26.7 178.7 -67.3 175.6 -178.4 145.4 31 ALA -71.8 -54.4 178.6 32 LEU -53.5 -37.1 179.6 169.1 63.8 33 THR -65.7 -48.7 -179.5 -85.2 34 ALA -59.8 -41.6 -179.7 35 HIS -69.2 -40.1 178.7 -62.3 163.1 36 LEU -62.8 -43.1 -179.6 -77.7 -175.0 37 TYR -61.7 -31.5 179.6 176.6 80.7 38 SER -76.0 -40.4 179.6 -88.3 39 LEU -67.2 -35.0 -179.8 -174.6 61.3 40 LEU -67.1 -43.5 -178.6 -102.8 64.8 41 GLN -69.0 -31.6 179.8 -64.8 -134.4 -67.7 42 THR -75.6 -29.7 179.0 -76.9 43 GLN -80.0 -22.3 177.4 -63.2 -171.4 -40.9 44 HIS -74.6 -47.3 179.7 -84.7 -57.8 45 ALA -59.5 -48.8 -179.0 46 LEU -60.1 -37.2 -179.5 -165.6 61.4 47 GLY -63.5 -51.3 178.7 48 ASP -57.6 -45.2 179.2 -71.8 24.6 49 ALA -59.9 -52.3 178.4 50 PHE -59.1 -26.6 179.8 -76.9 164.8 51 ALA -68.5 -70.0 179.5 52 ASP -40.2 -38.3 179.6 -166.1 57.4 53 LEU -71.6 -40.8 178.9 -97.1 -28.9 54 SER -58.5 -46.9 180.0 173.9 55 GLN -64.8 -31.6 -178.7 -173.6 160.1 57.9 56 LYS -99.3 -4.1 -177.8 -63.9 179.6 163.6 69.7 57 SER -126.7 74.6 -179.9 169.8 58 PRO -47.9 -35.7 -179.6 -32.7 43.5 59 GLU -67.4 -16.7 -176.6 61.8 -75.7 -167.0 60 LEU -138.8 9.9 -177.6 -107.0 21.3 61 GLN -48.8 -32.5 179.4 69.5 -177.7 -57.5 62 GLU -65.6 -69.7 -179.9 -145.3 172.0 62.3 63 GLU -42.4 -48.1 178.9 -58.0 89.7 157.3 64 PHE -64.5 -45.7 -179.7 -84.6 101.2 65 GLY -69.6 -32.4 178.4 66 TYR -59.9 -57.7 179.6 -176.2 44.6 67 ASN -63.9 -32.7 -179.8 -75.9 -77.3 68 ALA -67.5 -21.3 179.8 69 GLU -77.0 -57.7 178.5 -74.6 -50.7 56.3 70 THR -49.7 -55.5 179.9 -62.3 71 GLN -46.7 -56.6 180.0 -107.2 38.4 43.8 72 LYS -62.2 -30.4 178.3 -60.2 -172.8 177.6 -176.4 73 LEU -64.0 -73.9 179.7 168.4 73.2 74 LEU -40.6 -24.1 179.1 -96.7 38.8 75 CYS -70.4 -58.6 -179.8 -91.5 76 LYS -62.8 -25.9 178.6 70.0 -174.2 -62.0 178.1 77 ASN -83.3 -13.1 179.7 -97.6 41.8 78 GLY -90.7 -44.2 -179.5 79 GLU -49.1 -31.2 178.9 -47.6 -123.3 -62.2 80 THR -72.4 -69.0 178.3 -82.4 81 LEU -43.4 -32.9 179.9 167.7 66.2 82 LEU -66.2 -60.4 179.2 -175.5 69.4 83 GLY -50.6 -27.4 179.6 84 ALA -72.5 -46.0 179.5 85 VAL -65.1 -38.5 178.6 -179.9 86 ASN -59.2 -27.3 -180.0 -89.7 -77.1 87 PHE -80.8 -58.1 178.6 -177.1 75.1 88 PHE -45.8 -55.1 -179.7 173.3 76.1 89 VAL -56.9 -45.9 -178.7 162.3 90 SER -65.0 -31.7 179.3 -162.2 91 SER -68.5 -64.2 -179.7 -69.5 92 ILE -51.1 -25.7 179.8 -60.2 -169.4 93 ASN -68.1 -44.9 179.7 -178.7 -117.7 94 THR -62.7 -50.1 179.0 -79.7 95 LEU -51.4 -39.4 -179.1 175.3 74.3 96 VAL -83.2 -55.1 -178.5 155.5 97 THR -65.0 -29.2 -179.2 -82.7 98 LYS -124.6 -55.6 179.2 -64.0 162.8 -165.6 168.6 99 THR -54.1 -58.3 -179.8 -52.6 100 MET -68.2 -41.8 -178.5 -73.8 -177.0 171.2 101 GLU -57.6 -33.2 -179.9 -169.0 58.9 62.3 102 ASP -67.4 -41.3 177.8 177.9 -83.7 103 THR -67.5 -55.2 179.6 -70.8 104 LEU -52.8 -27.5 178.7 -162.6 69.6 105 MET -61.3 -48.9 179.6 170.6 75.0 -85.7 106 THR -66.5 -29.5 178.9 -68.2 107 VAL -66.1 -50.0 -179.8 172.0 108 LYS -58.7 -33.2 178.4 -59.6 177.4 179.7 -165.2 109 GLN -67.3 -55.6 177.9 -107.0 166.7 45.9 110 TYR -51.6 -49.2 -179.3 157.6 68.2 111 GLU -60.4 -36.8 -179.7 -57.8 -172.3 -60.4 112 ALA -71.5 -44.9 179.7 113 ALA -61.9 -40.6 179.3 114 ARG -58.2 -42.4 179.4 178.3 176.4 72.5 -164.6 115 LEU -61.6 -44.8 -179.2 -173.7 84.5 116 GLU -68.0 -42.2 177.9 -71.3 -163.6 -39.4 117 TYR -52.2 -51.0 180.0 163.5 74.4 118 ASP -63.3 -25.3 -179.6 -77.4 -31.6 119 ALA -75.7 -45.4 -179.9 120 TYR -68.5 -33.2 178.3 -74.9 86.6 121 ARG -63.6 -50.7 -179.4 -174.1 -156.1 71.2 -154.6 122 THR -60.4 -30.9 179.3 -81.6 123 ASP -66.9 -39.5 -179.1 -88.4 14.2 124 LEU -68.6 -40.8 179.1 -162.8 65.4 125 GLU -63.9 -39.4 179.6 -49.0 -171.5 -28.4 126 GLU -61.1 -47.3 -179.3 -107.9 156.3 50.8 127 LEU -65.8 -20.2 -179.6 -78.8 174.1 128 SER -68.6 -20.1 179.7 -67.2 129 LEU -74.7 -29.9 -179.3 -91.4 30.2 130 GLY -57.1 167.2 179.7 131 PRO -64.8 158.4 -178.8 29.5 -42.3 132 ARG -78.7 10.2 -179.1 -58.6 167.8 -177.7 178.7 133 ASP -59.6 176.2 178.4 68.3 -58.1 134 ALA -91.1 123.0 -177.7 135 GLY 129.9 -43.8 177.7 136 THR -79.4 -37.0 179.4 -79.6 137 ARG -66.7 -36.0 178.8 -74.0 -166.7 -176.8 -175.4 138 GLY -60.1 -42.6 -179.8 139 ARG -69.7 -33.5 179.6 -59.9 176.8 76.3 -165.3 140 LEU -69.1 -23.4 179.0 -84.3 169.6 141 GLU -74.0 -55.1 178.3 -100.9 169.9 54.6 142 SER -53.2 -51.8 -179.6 -57.0 143 ALA -57.3 -31.7 -179.8 144 GLN -69.4 -41.7 179.3 -167.1 72.4 44.9 145 ALA -56.2 -72.4 178.8 146 THR -39.5 -52.2 -179.9 48.2 147 PHE -53.2 -52.4 179.9 167.3 69.2 148 GLN -57.4 -51.4 179.8 -132.1 103.5 58.2 149 ALA -49.4 -63.4 -179.4 150 HIS -52.5 -24.5 178.0 -75.7 -78.1 151 ARG -73.3 -35.8 179.7 -165.9 -140.1 -72.7 121.0 152 ASP -64.0 -58.0 -180.0 -75.1 -26.6 153 LYS -53.0 -42.5 179.0 -173.8 161.8 83.4 170.7 154 TYR -58.4 -63.9 -179.5 162.1 65.7 155 GLU -54.1 -35.3 178.3 -85.5 165.3 30.1 156 LYS -65.5 -60.8 179.4 164.5 179.8 154.7 61.1 157 LEU -50.9 -39.2 179.2 -79.5 167.5 158 ARG -64.0 -20.7 179.2 176.2 -179.9 54.3 -175.2 159 GLY -84.4 -47.9 179.5 160 ASP -56.6 -20.1 -179.3 -58.4 -15.0 161 VAL -81.6 -55.2 179.7 165.1 162 ALA -54.1 -30.8 179.0 163 ILE -71.8 -69.9 179.8 -97.1 54.8 164 LYS -42.8 -42.1 179.9 -79.2 -159.0 175.5 -179.0 165 LEU -54.7 -54.0 179.8 -72.8 -179.6 166 LYS -52.8 -52.3 178.4 -100.0 -166.8 -73.7 70.8 167 PHE -54.3 -49.0 -179.8 -72.5 51.0 168 LEU -54.2 -52.4 179.9 -149.3 -175.0 169 GLU -56.4 -21.9 179.4 -177.1 70.7 -45.4 170 GLU -66.8 -56.1 179.3 -151.6 174.9 -53.7 171 ASN -60.0 -48.1 -179.5 -82.4 -147.3 172 LYS -44.3 -30.1 -179.8 163.8 -173.4 149.8 177.6 173 ILE -93.3 -43.3 179.2 -66.3 -171.4 174 LYS -62.2 -61.3 179.8 165.4 173.3 -66.1 -177.5 175 VAL -54.4 -46.8 -179.2 165.1 176 MET -73.2 14.5 178.5 -68.3 -66.7 -77.9 177 HIS -109.1 -65.1 178.5 -161.4 -108.2 178 LYS -46.3 -37.5 -179.0 -145.4 -113.4 -67.0 -67.9 179 GLN -78.9 -55.1 179.9 -59.3 -53.7 -60.5 180 LEU -58.1 -15.1 179.9 -92.9 173.4 181 LEU -86.8 -75.3 179.6 -118.9 -157.7 182 LEU -36.3 -47.0 179.0 -64.7 176.3 183 PHE -53.2 -70.1 -179.5 173.8 70.9 184 HIS -52.4 -29.5 179.1 172.3 93.5 185 ASN -72.6 -49.8 179.3 -86.7 -13.5 186 ALA -53.6 -38.4 179.6 187 VAL -59.2 -68.4 -179.8 158.5 188 SER -58.9 -22.7 179.0 64.4 189 ALA -74.2 -30.3 179.4 190 TYR -66.2 -59.2 -179.6 166.4 74.2 191 PHE -59.1 -44.9 179.6 -63.8 68.9 192 ALA -54.8 -66.5 -179.8 193 GLY -51.2 -25.9 -179.6 194 ASN -78.9 -41.9 179.2 -85.2 -65.1 195 GLN -68.8 -28.6 -179.8 -109.0 -133.7 -56.3 196 LYS -64.2 -21.5 -179.8 -175.6 175.2 175.9 -176.8 197 GLN -104.9 -23.4 -179.5 176.3 53.4 48.7 198 LEU -77.5 -29.1 178.8 0.0 0.0 199 GLU -79.1 -37.8 179.0 0.0 0.0 0.0 200 GLN -61.0 -56.7 179.8 -77.8 -177.7 -56.7 201 THR -103.7 110.0 0.0 -38.7 Alpha Carbon Cartesian Coordinates : Residue Type X Y Z 1 SER 71.290 59.060 37.143 2 ARG 70.533 60.918 33.890 3 THR 71.900 64.093 32.335 4 VAL 69.530 66.875 33.512 5 ASP 69.287 70.569 32.628 6 LEU 66.968 71.954 35.319 7 GLU 66.722 75.391 33.709 8 LEU 66.107 74.287 30.110 9 GLU 63.868 71.445 31.189 10 LEU 61.639 73.800 33.221 11 GLN 61.770 76.321 30.382 12 ILE 60.760 73.458 28.035 13 GLU 58.000 72.275 30.382 14 LEU 56.396 75.734 30.306 15 LEU 56.370 75.836 26.517 16 ARG 54.577 72.486 26.508 17 GLU 51.865 73.510 28.985 18 THR 51.440 76.824 27.180 19 LYS 51.046 74.974 23.871 20 ARG 48.482 72.603 25.305 21 LYS 46.503 75.538 26.837 22 TYR 46.741 77.417 23.537 23 GLU 45.438 74.407 21.656 24 SER 42.307 74.057 23.735 25 VAL 41.780 77.769 23.170 26 LEU 42.146 77.137 19.472 27 GLN 39.542 74.391 19.941 28 LEU 37.098 76.717 21.742 29 GLY 37.605 79.350 19.075 30 ARG 36.691 76.973 16.262 31 ALA 33.696 75.925 18.318 32 LEU 32.756 79.549 18.810 33 THR 33.327 79.921 15.074 34 ALA 31.076 77.004 14.145 35 HIS 28.326 78.246 16.432 36 LEU 28.348 81.855 15.213 37 TYR 28.067 80.638 11.651 38 SER 25.094 78.551 12.732 39 LEU 23.478 81.410 14.575 40 LEU 24.076 83.586 11.522 41 GLN 22.402 81.231 9.078 42 THR 19.479 80.795 11.447 43 GLN 19.088 84.548 11.842 44 HIS 19.049 84.955 8.056 45 ALA 16.358 82.344 7.715 46 LEU 14.431 83.842 10.640 47 GLY 14.793 87.257 9.078 48 ASP 13.352 86.143 5.755 49 ALA 10.480 84.310 7.510 50 PHE 9.526 87.332 9.630 51 ALA 9.729 89.224 6.336 52 ASP 7.432 86.992 4.317 53 LEU 4.951 87.114 7.216 54 SER 4.972 90.915 7.469 55 GLN 4.214 91.204 3.754 56 LYS 1.463 88.610 4.033 57 SER 0.037 89.637 7.400 58 PRO -1.462 93.185 7.388 59 GLU -2.908 92.638 10.844 60 LEU 0.657 92.163 12.080 61 GLN 2.938 93.572 9.359 62 GLU 4.608 95.957 11.788 63 GLU 5.672 93.429 14.427 64 PHE 6.884 90.977 11.776 65 GLY 8.777 93.618 9.761 66 TYR 10.146 95.227 12.925 67 ASN 11.674 91.903 13.993 68 ALA 12.661 91.150 10.390 69 GLU 14.802 94.275 10.558 70 THR 16.837 93.494 13.675 71 GLN 17.438 89.956 12.427 72 LYS 18.803 91.102 9.033 73 LEU 20.714 93.807 10.925 74 LEU 22.364 91.514 13.453 75 CYS 23.261 89.353 10.458 76 LYS 25.481 91.767 8.544 77 ASN 26.920 92.801 11.916 78 GLY 27.613 89.193 12.722 79 GLU 29.305 88.314 9.439 80 THR 31.823 90.929 10.556 81 LEU 32.400 89.749 14.139 82 LEU 32.625 86.333 12.486 83 GLY 35.381 87.171 10.016 84 ALA 37.192 88.623 13.026 85 VAL 36.981 85.405 15.025 86 ASN 37.977 83.564 11.858 87 PHE 41.046 85.810 11.978 88 PHE 41.883 85.513 15.676 89 VAL 41.584 81.733 15.371 90 SER 43.619 81.523 12.183 91 SER 46.358 83.633 13.751 92 ILE 46.730 81.698 16.987 93 ASN 46.748 78.532 14.912 94 THR 49.887 79.595 13.076 95 LEU 51.604 80.693 16.281 96 VAL 50.822 77.236 17.655 97 THR 50.947 75.034 14.579 98 LYS 54.136 76.440 13.101 99 THR 55.867 79.009 15.258 100 MET 55.640 76.854 18.392 101 GLU 55.828 73.490 16.604 102 ASP 59.204 74.461 15.147 103 THR 60.692 75.137 18.578 104 LEU 59.095 72.027 20.094 105 MET 60.628 70.332 17.043 106 THR 64.107 71.261 18.293 107 VAL 63.211 70.184 21.830 108 LYS 62.329 66.618 20.809 109 GLN 65.630 66.657 18.918 110 TYR 67.544 67.938 21.949 111 GLU 65.776 65.382 24.146 112 ALA 66.638 62.485 21.821 113 ALA 70.287 63.463 21.502 114 ARG 70.411 63.864 25.264 115 LEU 69.149 60.303 25.622 116 GLU 71.838 59.032 23.229 117 TYR 74.617 61.049 24.809 118 ASP 73.819 59.262 28.087 119 ALA 73.754 55.913 26.327 120 TYR 77.176 56.231 24.705 121 ARG 78.588 57.687 27.935 122 THR 77.270 54.695 29.869 123 ASP 78.801 52.299 27.323 124 LEU 82.151 53.893 27.975 125 GLU 81.788 53.678 31.763 126 GLU 80.910 50.009 31.325 127 LEU 84.003 49.224 29.286 128 SER 86.014 50.967 31.985 129 LEU 85.260 48.067 34.278 130 GLY 87.065 45.725 31.926 131 PRO 90.735 44.699 32.335 132 ARG 93.447 47.152 31.248 133 ASP 94.523 44.682 28.507 134 ALA 94.978 45.211 24.769 135 GLY 91.666 44.629 23.077 136 THR 89.726 46.391 25.778 137 ARG 91.723 49.546 25.093 138 GLY 90.958 49.230 21.418 139 ARG 87.254 49.209 22.260 140 LEU 87.558 52.137 24.688 141 GLU 88.993 54.020 21.737 142 SER 86.109 53.340 19.365 143 ALA 83.754 54.023 22.251 144 GLN 85.538 57.292 23.041 145 ALA 84.989 58.666 19.525 146 THR 81.248 57.980 19.323 147 PHE 80.896 59.255 22.890 148 GLN 82.647 62.581 22.220 149 ALA 80.678 63.000 19.006 150 HIS 77.310 62.346 20.620 151 ARG 78.342 64.848 23.307 152 ASP 78.786 67.394 20.529 153 LYS 75.359 66.916 18.934 154 TYR 73.819 67.040 22.404 155 GLU 75.481 70.274 23.591 156 LYS 74.854 72.029 20.258 157 LEU 71.165 71.154 20.205 158 ARG 70.940 72.148 23.871 159 GLY 72.183 75.505 22.654 160 ASP 69.870 75.787 19.683 161 VAL 67.026 75.321 22.185 162 ALA 67.729 78.013 24.748 163 ILE 68.066 80.324 21.736 164 LYS 64.888 79.313 19.903 165 LEU 63.071 79.400 23.228 166 LYS 63.930 83.081 23.753 167 PHE 62.859 84.035 20.205 168 LEU 59.580 82.077 20.561 169 GLU 58.625 83.815 23.826 170 GLU 59.117 87.038 21.906 171 ASN 56.314 86.098 19.516 172 LYS 54.098 84.477 22.119 173 ILE 53.791 87.993 23.431 174 LYS 53.834 90.054 20.241 175 VAL 51.408 87.850 18.288 176 MET 49.157 87.250 21.318 177 HIS 48.784 91.008 21.644 178 LYS 47.736 92.106 18.170 179 GLN 45.405 89.088 18.408 180 LEU 44.070 89.228 21.985 181 LEU 43.287 92.840 21.051 182 LEU 41.639 92.713 17.643 183 PHE 39.537 89.850 18.992 184 HIS 38.251 91.768 21.998 185 ASN 37.868 94.889 19.847 186 ALA 35.847 93.159 17.132 187 VAL 33.686 91.887 19.984 188 SER 32.809 95.230 21.579 189 ALA 32.669 96.674 18.035 190 TYR 29.934 94.166 17.155 191 PHE 27.677 95.075 20.060 192 ALA 28.455 98.784 19.730 193 GLY 27.657 99.053 16.029 194 ASN 24.503 96.986 16.627 195 GLN 22.958 99.089 19.425 196 LYS 23.625 102.202 17.352 197 GLN 21.054 100.873 14.877 198 LEU 18.691 99.247 17.393 199 GLU 18.101 102.538 19.211 200 GLN 17.554 104.366 15.908 201 THR 14.932 101.920 14.633 Richards-Kundrot Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 C S S S S/H H H H H H 10 H H H H H H H H H H 20 H H H H H H H H H H 30 H H H H H H H H H H 40 H H H H H H H H H H 50 H H H H/T T T T C C H 60 H H H H H H H H H H 70 H H H H H H H H H H 80 H H H H H H H H H H 90 H H H H H H H H H/H H 100 H H H H H H H H H H 110 H H H H H H H H H H 120 H H H H H H H H H H 130 C C C H H H H H H H 140 H H H H H H H H H H 150 H H H H H H H H H H 160 H H H H H H H H H H 170 H H H H H H H H H H 180 H H H/H H H H H H H H 190 H H H H H H H H H H 200 H Kabsch-Sander Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 h H H H H H 10 H H H H H H H H H H 20 H H H H H H H H H H 30 H H H H H H H H H H 40 H H H H H H H H H H 50 H H H H H H h T T h 60 H H H H H H H H H H 70 H H H H H H H H H H 80 H H H H H H H H H H 90 H H H H H H H h H H 100 H H H H H H H H H H 110 H H H H H H H H H H 120 H H H H H H H h T t 130 S t T h H H H H H 140 H H H H H H H H H H 150 H H H H H H H H H H 160 H H H H H H H H H H 170 H H H H H H H H H H 180 H H H H H H H H H H 190 H H H H H H H H h T 200 t Buried Surface Area Percentages : Residue Type Buried Area % Buried % Polar Cover 1 SER 0.0 0.0 95.5 2 ARG 108.2 51.8 78.8 3 THR 78.8 73.7 61.3 4 VAL 74.1 62.4 69.4 5 ASP 91.7 83.0 60.6 6 LEU 26.0 17.6 75.2 7 GLU 0.0 0.0 84.5 8 LEU 135.4 91.6 38.8 9 GLU 104.7 75.5 64.1 10 LEU 31.9 21.6 73.7 11 GLN 59.0 39.7 63.2 12 ILE 138.7 96.7 36.4 13 GLU 51.3 37.0 70.4 14 LEU 34.8 23.5 76.0 15 LEU 131.8 89.2 37.0 16 ARG 137.6 65.9 62.8 17 GLU 51.9 37.5 76.3 18 THR 86.9 81.3 46.3 19 LYS 149.6 86.3 52.4 20 ARG 75.7 36.2 78.4 21 LYS 51.3 29.6 76.9 22 TYR 148.7 82.1 34.4 23 GLU 76.7 55.3 64.0 24 SER 26.9 32.1 68.9 25 VAL 57.4 48.3 60.9 26 LEU 141.5 95.7 54.7 27 GLN 43.0 28.9 79.4 28 LEU 26.8 18.1 77.5 29 GLY 28.0 80.5 53.5 30 ARG 108.3 51.8 70.1 31 ALA 33.7 46.5 68.8 32 LEU 77.0 52.1 55.4 33 THR 76.7 71.7 55.8 34 ALA 22.2 30.6 71.4 35 HIS 30.6 20.4 74.3 36 LEU 121.8 82.4 39.2 37 TYR 66.0 36.5 71.5 38 SER 21.0 25.1 75.2 39 LEU 57.5 38.9 71.9 40 LEU 138.9 94.0 46.1 41 GLN 51.6 34.7 71.8 42 THR 27.3 25.5 71.4 43 GLN 125.6 84.5 48.4 44 HIS 78.0 51.9 67.8 45 ALA 13.2 18.2 78.7 46 LEU 77.0 52.1 59.6 47 GLY 34.8 100.0 54.8 48 ASP 26.8 24.2 76.6 49 ALA 28.1 38.7 64.5 50 PHE 112.9 67.7 51.1 51 ALA 46.5 64.1 64.6 52 ASP 49.1 44.4 72.7 53 LEU 74.3 50.3 56.5 54 SER 66.7 79.8 59.2 55 GLN 10.9 7.3 87.6 56 LYS 56.8 32.8 81.7 57 SER 73.5 88.0 52.4 58 PRO 43.3 34.8 85.7 59 GLU 29.7 21.4 73.6 60 LEU 69.5 47.0 71.5 61 GLN 50.7 34.1 74.9 62 GLU 1.4 1.0 83.1 63 GLU 52.3 37.8 65.5 64 PHE 121.0 72.5 48.9 65 GLY 18.0 51.7 70.9 66 TYR 43.9 24.3 78.2 67 ASN 53.6 44.4 61.2 68 ALA 68.0 93.7 51.9 69 GLU 45.2 32.6 75.4 70 THR 51.1 47.8 60.8 71 GLN 122.2 82.2 49.8 72 LYS 83.3 48.0 73.4 73 LEU 120.7 81.6 51.7 74 LEU 106.8 72.3 64.7 75 CYS 98.3 99.1 60.3 76 LYS 34.7 20.0 80.3 77 ASN 91.5 75.7 59.3 78 GLY 33.3 95.6 54.1 79 GLU 56.7 40.9 66.9 80 THR 21.1 19.7 79.0 81 LEU 132.7 89.8 33.9 82 LEU 125.1 84.6 50.8 83 GLY 5.7 16.5 77.3 84 ALA 50.4 69.5 55.2 85 VAL 116.6 98.1 39.3 86 ASN 61.0 50.5 61.7 87 PHE 71.7 43.0 71.3 88 PHE 149.0 89.3 36.8 89 VAL 103.5 87.2 51.2 90 SER 20.6 24.6 75.9 91 SER 62.7 75.0 61.3 92 ILE 142.7 99.4 26.8 93 ASN 82.9 68.6 65.2 94 THR 44.1 41.2 77.1 95 LEU 146.4 99.1 33.9 96 VAL 114.4 96.3 41.8 97 THR 54.9 51.4 64.4 98 LYS 41.3 23.8 77.7 99 THR 67.7 63.3 55.8 100 MET 158.7 99.6 29.0 101 GLU 74.1 53.5 70.5 102 ASP 39.3 35.5 75.7 103 THR 101.3 94.7 43.2 104 LEU 134.5 91.0 50.2 105 MET 71.6 44.9 75.3 106 THR 99.6 93.2 52.0 107 VAL 118.8 100.0 35.6 108 LYS 72.6 41.9 73.4 109 GLN 66.9 45.1 60.6 110 TYR 181.0 100.0 36.2 111 GLU 99.4 71.7 66.4 112 ALA 16.9 23.3 78.4 113 ALA 69.9 96.3 50.8 114 ARG 182.3 87.3 55.7 115 LEU 15.8 10.7 82.2 116 GLU 71.4 51.5 66.0 117 TYR 150.4 83.1 48.0 118 ASP 93.2 84.3 60.4 119 ALA 21.3 29.3 72.1 120 TYR 112.4 62.1 62.4 121 ARG 156.8 75.1 66.5 122 THR 57.5 53.8 81.1 123 ASP 36.2 32.7 74.2 124 LEU 125.5 84.9 54.2 125 GLU 49.2 35.5 77.9 126 GLU 41.1 29.7 73.0 127 LEU 113.7 76.9 61.5 128 SER 37.9 45.3 66.3 129 LEU 24.0 16.2 85.8 130 GLY 15.9 45.7 66.5 131 PRO 32.3 25.9 78.7 132 ARG 2.9 1.4 92.5 133 ASP 45.5 41.2 73.4 134 ALA 0.6 0.8 80.9 135 GLY 0.0 0.0 81.8 136 THR 90.3 84.5 58.6 137 ARG 57.2 27.4 77.1 138 GLY 3.7 10.7 76.0 139 ARG 57.0 27.3 77.4 140 LEU 98.1 66.4 58.0 141 GLU 18.3 13.2 81.4 142 SER 9.4 11.3 80.0 143 ALA 57.6 79.4 56.2 144 GLN 77.3 52.0 67.0 145 ALA 11.3 15.5 79.5 146 THR 49.5 46.3 59.2 147 PHE 147.1 88.2 54.7 148 GLN 78.3 52.7 75.6 149 ALA 22.0 30.3 74.1 150 HIS 114.7 76.4 53.9 151 ARG 139.6 66.8 63.0 152 ASP 26.8 24.3 81.0 153 LYS 67.7 39.0 68.9 154 TYR 174.5 96.4 44.4 155 GLU 71.8 51.8 67.4 156 LYS 37.3 21.5 84.3 157 LEU 128.7 87.1 51.1 158 ARG 126.3 60.5 58.2 159 GLY 5.4 15.6 78.7 160 ASP 63.9 57.9 59.7 161 VAL 118.5 99.7 34.1 162 ALA 36.6 50.5 60.5 163 ILE 54.4 37.9 68.4 164 LYS 105.6 60.9 70.1 165 LEU 140.1 94.8 39.8 166 LYS 49.9 28.8 75.3 167 PHE 38.7 23.2 77.7 168 LEU 138.4 93.6 43.4 169 GLU 59.2 42.7 68.1 170 GLU 26.7 19.3 83.3 171 ASN 68.9 57.0 56.6 172 LYS 114.6 66.1 60.5 173 ILE 35.0 24.4 78.7 174 LYS 33.0 19.0 79.7 175 VAL 79.5 66.9 50.2 176 MET 136.9 85.9 38.8 177 HIS 31.8 21.2 79.2 178 LYS 50.7 29.2 74.6 179 GLN 143.9 96.8 36.7 180 LEU 53.5 36.2 64.1 181 LEU 61.3 41.5 77.0 182 LEU 75.2 50.8 63.1 183 PHE 115.6 69.3 42.3 184 HIS 41.4 27.6 73.8 185 ASN 50.2 41.5 66.9 186 ALA 55.9 77.0 50.1 187 VAL 71.8 60.5 48.1 188 SER 30.6 36.6 73.6 189 ALA 22.2 30.6 74.6 190 TYR 142.9 78.9 52.8 191 PHE 45.1 27.1 68.1 192 ALA 14.9 20.5 79.3 193 GLY 11.0 31.7 74.6 194 ASN 110.0 91.0 46.8 195 GLN 14.6 9.8 83.4 196 LYS 14.1 8.1 86.6 197 GLN 84.9 57.1 68.2 198 LEU 107.9 73.0 69.8 199 GLU 77.6 56.0 86.2 200 GLN 37.9 25.5 83.9 201 THR 36.6 34.2 76.0