Protein Data Bank File : 1b6a Title : ANGIOGENESIS INHIBITOR 13-JAN-99 1B6A Number of Amino Acid Residues : 355 Amino Acid Sequence : 1 2 3 4 5 6 7 8 9 10 0 LYS VAL GLN THR ASP PRO PRO SER VAL PRO 10 ILE CYS ASP LEU TYR PRO ASN GLY VAL PHE 20 PRO LYS GLY GLN GLU CYS GLU TYR PRO GLU 30 GLU LYS LYS ALA LEU ASP GLN ALA SER GLU 40 GLU ILE TRP ASN ASP PHE ARG GLU ALA ALA 50 GLU ALA HIS ARG GLN VAL ARG LYS TYR VAL 60 MET SER TRP ILE LYS PRO GLY MET THR MET 70 ILE GLU ILE CYS GLU LYS LEU GLU ASP CYS 80 SER ARG LYS LEU ILE LYS GLU ASN GLY LEU 90 ASN ALA GLY LEU ALA PHE PRO THR GLY CYS 100 SER LEU ASN ASN CYS ALA ALA HIS TYR THR 110 PRO ASN ALA GLY ASP THR THR VAL LEU GLN 120 TYR ASP ASP ILE CYS LYS ILE ASP PHE GLY 130 THR HIS ILE SER GLY ARG ILE ILE ASP CYS 140 ALA PHE THR VAL THR PHE ASN PRO LYS TYR 150 ASP THR LEU LEU LYS ALA VAL LYS ASP ALA 160 THR ASN THR GLY ILE LYS CYS ALA GLY ILE 170 ASP VAL ARG LEU CYS ASP VAL GLY GLU ALA 180 ILE GLN GLU VAL MET GLU SER TYR GLU VAL 190 GLU ILE ASP GLY LYS THR TYR GLN VAL LYS 200 PRO ILE ARG ASN LEU ASN GLY HIS SER ILE 210 GLY GLN TYR ARG ILE HIS ALA GLY LYS THR 220 VAL PRO ILE VAL LYS GLY GLY GLU ALA THR 230 ARG MET GLU GLU GLY GLU VAL TYR ALA ILE 240 GLU THR PHE GLY SER THR GLY LYS GLY VAL 250 VAL HIS ASP ASP MET GLU CYS SER HIS TYR 260 MET LYS ASN PHE ASP VAL GLY HIS VAL PRO 270 ILE ARG LEU PRO ARG THR LYS HIS LEU LEU 280 ASN VAL ILE ASN GLU ASN PHE GLY THR LEU 290 ALA PHE CYS ARG ARG TRP LEU ASP ARG LEU 300 GLY GLU SER LYS TYR LEU MET ALA LEU LYS 310 ASN LEU CYS ASP LEU GLY ILE VAL ASP PRO 320 TYR PRO PRO LEU CYS ASP ILE LYS GLY SER 330 TYR THR ALA GLN PHE GLU HIS THR ILE LEU 340 LEU ARG PRO THR CYS LYS GLU VAL VAL SER 350 ARG GLY ASP ASP TYR Main and Side Chain Dihedral Angles : Residue Type Phi Psi Omega Chi 1 Chi 2 Chi 3 Chi 4 1 LYS 0.0 -135.3 162.7 -65.4 -69.2 -179.7 180.0 2 VAL -99.2 154.4 177.4 -170.1 3 GLN -68.2 146.9 -175.3 -177.3 59.7 -94.1 4 THR -86.3 171.9 -167.6 57.9 5 ASP -55.1 -58.9 155.7 -63.1 0.4 6 PRO -97.2 121.3 -170.1 24.6 -17.0 7 PRO -47.8 132.0 173.9 -4.3 16.5 8 SER -144.7 -13.6 179.8 57.9 9 VAL -84.3 120.9 174.7 -174.5 10 PRO -51.9 143.5 179.9 -15.0 25.8 11 ILE -58.5 -35.1 179.5 -55.0 -53.9 12 CYS -66.3 -24.4 175.0 61.3 13 ASP -84.4 -17.2 174.6 -65.8 -12.1 14 LEU -78.8 -25.7 -178.4 -63.8 175.0 15 TYR -126.9 74.6 -168.1 -61.9 -85.7 16 PRO -65.2 -24.2 173.0 29.8 -32.6 17 ASN -71.4 -16.9 171.8 -6.4 -126.0 18 GLY 85.1 16.7 177.1 19 VAL -112.0 116.7 -171.9 179.1 20 PHE -104.2 158.8 -176.2 -62.9 -82.9 21 PRO -59.6 136.9 171.8 -16.2 21.5 22 LYS -69.2 151.7 167.7 -65.7 -178.4 170.9 -170.7 23 GLY -79.4 -164.3 177.6 24 GLN -70.6 119.0 179.0 177.9 -156.3 6.6 25 GLU -97.4 135.9 -170.5 -64.0 175.3 -67.9 26 CYS -133.3 137.0 166.3 -62.1 27 GLU -63.3 146.6 174.4 -50.6 -177.9 -11.7 28 TYR -67.4 145.3 -179.6 -74.8 -67.9 29 PRO -56.0 23.2 -99.5 18.2 -33.3 30 GLU 34.3 -86.9 -168.8 -53.7 -158.5 0.4 31 GLU -71.5 -40.3 -177.6 -177.9 -147.4 35.5 32 LYS -75.7 -32.5 173.6 -69.7 -165.4 169.5 -40.8 33 LYS -62.7 -41.5 174.5 -154.5 178.6 86.3 -151.9 34 ALA -62.1 -45.6 -178.8 35 LEU -64.6 -39.2 174.2 -163.1 65.0 36 ASP -60.9 -50.2 176.9 -150.1 -39.4 37 GLN -60.3 -30.4 178.7 175.4 55.7 -146.1 38 ALA -64.7 -26.6 179.1 39 SER -105.1 21.0 -178.6 -71.8 40 GLU -56.5 -36.1 179.8 -165.7 65.4 16.4 41 GLU -66.2 -32.9 175.9 -70.0 -177.0 32.5 42 ILE -68.8 -45.6 -177.8 -61.9 167.9 43 TRP -63.8 -39.5 178.4 -46.8 137.8 44 ASN -60.8 -37.7 174.4 -159.7 55.6 45 ASP -66.6 -43.0 172.3 -72.9 -15.4 46 PHE -60.3 -41.4 -179.5 -78.5 -76.1 47 ARG -65.3 -36.4 175.4 -68.5 165.2 -171.2 156.1 48 GLU -62.8 -44.8 178.2 -174.3 -176.6 -6.4 49 ALA -65.4 -36.2 -178.3 50 ALA -71.0 -36.9 178.3 51 GLU -67.6 -35.0 171.6 179.8 69.1 20.5 52 ALA -60.0 -45.6 -179.2 53 HIS -60.2 -45.1 177.6 -165.3 -75.9 54 ARG -59.7 -45.7 -178.2 -78.7 -172.7 -72.4 -85.6 55 GLN -71.2 -37.6 175.1 -61.1 -162.5 18.7 56 VAL -62.7 -48.7 -174.6 172.2 57 ARG -69.3 -34.1 173.9 76.3 -156.7 -166.3 -148.2 58 LYS -59.1 -43.1 176.9 -175.8 163.0 81.3 -99.9 59 TYR -61.0 -48.5 178.0 168.4 62.7 60 VAL -56.6 -43.3 -176.4 172.9 61 MET -65.2 -25.8 -179.9 -67.2 176.9 -157.8 62 SER -71.3 -25.5 -172.6 79.0 63 TRP -125.4 -13.5 -175.4 52.9 -105.2 64 ILE -68.0 126.0 -173.1 -170.3 172.8 65 LYS -146.8 152.5 172.7 -67.7 -69.3 -169.9 -50.5 66 PRO -61.7 149.6 -175.4 8.1 -8.0 67 GLY 103.6 -29.1 175.8 68 MET -75.7 146.2 174.4 -59.9 -176.7 64.1 69 THR -77.6 158.5 177.6 62.4 70 MET -64.2 -36.7 174.4 -53.2 -49.3 -61.0 71 ILE -60.4 -46.7 176.0 -67.6 177.7 72 GLU -56.0 -41.7 -179.2 -69.5 162.4 -7.5 73 ILE -63.3 -49.8 -174.6 -70.0 164.3 74 CYS -67.5 -38.0 -178.9 -72.3 75 GLU -68.8 -38.7 177.5 -63.9 -173.9 -21.5 76 LYS -65.7 -43.0 175.3 -169.9 168.0 176.5 68.2 77 LEU -61.4 -50.3 -175.7 -171.8 157.7 78 GLU -66.0 -36.2 173.9 -72.0 165.8 10.0 79 ASP -54.4 -47.4 -178.0 -113.3 -85.0 80 CYS -64.9 -45.0 -179.8 -173.4 81 SER -59.8 -44.3 177.6 -71.7 82 ARG -59.3 -42.0 177.7 -69.5 -167.9 -177.2 92.0 83 LYS -66.3 -45.4 -173.6 -72.0 172.8 -170.1 176.8 84 LEU -73.0 -34.3 177.5 -62.9 -159.1 85 ILE -79.8 -10.6 -175.8 -151.5 67.8 86 LYS 57.1 63.6 -174.9 -155.5 176.7 -164.4 176.4 87 GLU -47.3 131.2 179.4 -173.6 -178.8 65.0 88 ASN -149.2 83.8 178.5 174.6 27.8 89 GLY 51.9 -129.5 -177.8 90 LEU -94.1 2.2 179.1 -61.8 174.1 91 ASN -86.0 -25.0 176.4 -74.6 -49.6 92 ALA -157.0 136.4 176.2 93 GLY 172.9 -154.4 -178.7 94 LEU -93.2 126.5 -170.5 -49.5 -171.5 95 ALA -79.6 -28.9 -178.3 96 PHE -165.3 162.5 -174.5 54.5 85.1 97 PRO -62.7 156.7 -179.0 -14.0 20.5 98 THR -76.3 111.4 172.1 -56.8 99 GLY -76.1 139.1 174.8 100 CYS -144.5 43.7 -173.3 49.8 101 SER -61.1 136.3 -172.2 -53.0 102 LEU -111.1 138.5 162.8 -66.9 171.3 103 ASN 63.6 -111.8 179.2 -60.8 -33.8 104 ASN -76.3 -16.0 177.4 62.6 -57.0 105 CYS -81.9 126.1 -171.8 -179.1 106 ALA -99.6 -29.2 -171.1 107 ALA -159.7 156.5 170.0 108 HIS 67.3 27.0 165.2 -62.6 169.7 109 TYR -104.2 125.1 158.1 165.5 73.9 110 THR -135.0 146.9 -179.0 -164.4 111 PRO -63.9 144.4 166.5 21.7 -34.5 112 ASN -93.5 171.0 176.8 -73.1 -31.6 113 ALA -53.2 139.6 178.9 114 GLY 83.5 -6.8 176.6 115 ASP -66.4 120.8 -178.2 -169.9 -26.0 116 THR -96.7 10.4 -179.4 55.1 117 THR -57.7 132.6 177.6 -58.3 118 VAL -114.1 131.8 178.9 168.7 119 LEU -63.8 130.2 -176.2 -174.5 63.1 120 GLN -108.4 162.7 -179.8 -57.7 -61.6 -47.3 121 TYR -57.9 -41.9 -179.4 172.5 73.7 122 ASP -86.0 5.6 -178.7 -70.9 -57.6 123 ASP -75.4 151.5 169.9 -75.8 -13.4 124 ILE -117.7 112.3 -166.5 174.6 161.2 125 CYS -115.9 124.8 179.9 176.5 126 LYS -96.3 113.7 -179.6 -77.9 69.9 69.3 178.8 127 ILE -95.3 111.3 -176.1 -65.2 -64.6 128 ASP -129.4 111.8 -177.9 -170.5 -20.1 129 PHE -144.6 157.4 -170.8 70.2 -80.9 130 GLY -132.7 144.0 174.6 131 THR -121.2 158.4 172.1 48.0 132 HIS -150.1 153.7 165.3 75.8 92.2 133 ILE -123.1 124.6 -179.7 -66.5 -64.9 134 SER 52.7 34.1 178.7 -56.7 135 GLY 81.7 -0.6 173.3 136 ARG -84.6 108.8 -165.4 -49.1 -51.1 179.8 174.0 137 ILE -99.8 137.2 167.8 -65.0 161.1 138 ILE -105.6 123.2 171.6 -66.0 -61.6 139 ASP -113.7 112.2 -177.8 -169.3 -11.4 140 CYS -145.1 143.2 -167.8 178.8 141 ALA -151.5 149.8 177.6 142 PHE -145.8 166.5 -179.1 60.8 -83.1 143 THR -109.9 131.1 177.7 -56.8 144 VAL -101.1 131.0 174.0 170.2 145 THR -141.8 161.6 175.8 54.7 146 PHE -123.4 -21.0 176.7 -54.0 -74.9 147 ASN -94.8 129.0 -179.1 -172.2 -32.6 148 PRO -67.4 -9.9 176.5 20.9 -34.4 149 LYS -57.5 -26.7 -179.3 77.2 -175.5 179.4 -171.2 150 TYR -91.0 6.0 -169.2 -61.0 -67.1 151 ASP -61.1 -42.7 -178.1 -78.2 -7.3 152 THR -69.8 -33.6 175.7 -56.4 153 LEU -62.2 -41.4 179.1 169.2 66.1 154 LEU -67.6 -40.7 179.2 -93.0 62.1 155 LYS -63.1 -39.9 180.0 179.2 -176.1 48.6 174.5 156 ALA -57.0 -47.6 -173.4 157 VAL -72.6 -40.3 174.6 175.1 158 LYS -58.8 -45.0 176.8 -169.5 -175.2 -70.2 -177.1 159 ASP -62.8 -41.9 177.7 -162.8 7.6 160 ALA -62.5 -42.8 177.0 161 THR -63.0 -42.1 179.9 -67.4 162 ASN -68.3 -32.2 173.6 -77.1 -30.1 163 THR -63.8 -44.2 176.8 -64.8 164 GLY -64.1 -37.2 176.3 165 ILE -64.6 -39.8 178.8 -69.1 166.2 166 LYS -70.5 -34.8 -178.4 174.7 -172.9 177.6 -175.8 167 CYS -72.9 -29.4 -173.2 -69.6 168 ALA -63.8 151.2 175.3 169 GLY 174.5 168.7 172.8 170 ILE -61.7 129.9 -179.5 -66.3 168.7 171 ASP 75.3 8.9 176.1 -81.0 -31.7 172 VAL -83.1 137.8 -179.7 170.1 173 ARG -74.9 132.8 -179.4 -55.4 142.3 98.0 -156.7 174 LEU -61.6 -33.4 178.3 -69.1 161.1 175 CYS -63.0 -30.9 -178.8 59.7 176 ASP -73.0 -36.2 176.1 -70.6 -10.2 177 VAL -61.4 -45.8 179.5 176.2 178 GLY -58.8 -47.4 -179.2 179 GLU -61.2 -41.5 179.8 -173.6 158.2 -22.7 180 ALA -63.6 -45.0 178.2 181 ILE -57.8 -48.7 -177.5 -72.3 169.4 182 GLN -63.3 -39.0 179.6 174.0 176.7 34.6 183 GLU -61.0 -42.5 179.0 -178.3 -175.4 -10.6 184 VAL -69.9 -49.0 -175.4 165.9 185 MET -60.0 -38.4 -175.6 -148.0 -169.2 -75.2 186 GLU -81.0 -5.9 174.1 -69.3 -176.6 -8.9 187 SER -75.8 -10.0 -178.6 73.4 188 TYR -98.3 136.8 172.9 -74.7 86.4 189 GLU -123.1 141.7 -175.9 49.9 -175.7 10.0 190 VAL -129.4 155.4 175.7 -61.5 191 GLU -127.7 120.7 -176.3 -177.6 178.0 28.2 192 ILE -130.5 119.0 178.7 -56.7 172.8 193 ASP 52.4 46.9 173.3 -61.6 -44.3 194 GLY 76.6 7.7 177.0 195 LYS -117.8 137.5 178.1 -174.2 159.8 -168.7 60.0 196 THR -101.3 148.5 -179.7 68.9 197 TYR -138.4 142.8 161.9 -55.8 88.7 198 GLN -87.8 124.6 -174.8 175.1 -168.5 -126.8 199 VAL -63.4 134.5 -176.8 -177.9 200 LYS -115.1 130.8 167.1 -64.0 -171.0 -173.5 -176.0 201 PRO -59.5 146.3 173.9 -7.2 21.5 202 ILE -83.2 107.9 -164.6 -59.1 -176.0 203 ARG -67.8 -25.3 179.3 71.4 -171.2 -171.7 -137.6 204 ASN -103.7 24.7 165.9 61.1 -24.1 205 LEU -117.8 150.6 -168.0 -67.9 177.0 206 ASN -146.1 156.4 159.0 -53.3 97.8 207 GLY -80.6 -178.0 -167.5 208 HIS -163.7 146.5 168.3 52.2 95.8 209 SER -70.6 160.4 -176.2 58.6 210 ILE -123.9 135.8 173.4 -70.8 169.6 211 GLY -126.5 178.0 -175.4 212 GLN -65.4 119.0 -172.9 -161.5 178.7 12.3 213 TYR 59.1 23.0 -173.5 -62.0 -78.5 214 ARG -138.4 94.1 -176.1 -168.7 171.9 -169.0 172.6 215 ILE -60.0 -33.0 176.3 -176.7 66.6 216 HIS -123.4 104.1 -175.2 -170.0 -30.4 217 ALA -90.7 9.4 163.6 218 GLY 112.2 -16.0 174.6 219 LYS -98.5 135.4 -177.9 -77.4 -168.1 -179.9 160.5 220 THR -110.2 144.4 178.9 61.9 221 VAL -107.1 103.1 -177.7 -176.0 222 PRO -65.4 154.9 174.6 30.2 -37.3 223 ILE -116.9 11.7 168.5 65.7 175.9 224 VAL -135.8 165.9 177.5 -66.3 225 LYS -66.8 162.6 169.6 68.5 -179.4 62.3 179.6 226 GLY 99.6 9.5 -176.3 227 GLY -86.6 -163.0 -176.8 228 GLU -84.7 144.3 173.4 -64.3 179.8 -32.4 229 ALA -81.6 12.8 168.0 230 THR -45.7 134.5 -177.4 -53.6 231 ARG -93.5 150.3 168.9 -76.3 173.5 153.1 85.4 232 MET -73.7 142.7 -173.4 -64.7 -178.5 156.4 233 GLU -120.5 152.1 174.4 -60.9 172.1 63.9 234 GLU -54.3 131.0 175.1 -174.6 176.5 89.1 235 GLY 95.0 -12.1 -180.0 236 GLU -76.9 158.9 179.2 -65.7 179.6 -37.1 237 VAL -126.7 135.9 -174.1 174.1 238 TYR -131.1 139.6 161.1 -80.6 -88.8 239 ALA -89.4 110.9 175.5 240 ILE -96.3 106.8 -174.8 -53.5 -64.5 241 GLU -129.6 141.9 173.0 56.2 -170.6 -47.2 242 THR -131.7 151.1 -177.6 78.3 243 PHE -130.0 130.3 177.9 -62.4 84.9 244 GLY -120.2 151.1 -175.4 245 SER -142.8 153.3 169.3 179.9 246 THR -97.2 2.8 -175.2 63.4 247 GLY -99.1 -133.1 -178.2 248 LYS -76.6 -21.2 -172.9 -73.7 -79.3 -74.4 163.8 249 GLY 78.9 21.4 177.1 250 VAL -137.6 140.9 175.6 -179.3 251 VAL -109.1 152.9 173.0 -69.5 252 HIS -129.1 159.8 175.0 59.7 -89.6 253 ASP -68.1 136.5 -175.0 -59.1 -18.2 254 ASP -158.2 155.5 -178.3 -164.0 31.2 255 MET 67.6 -179.9 179.9 -59.0 -174.8 -46.6 256 GLU -68.3 151.4 176.3 -163.4 167.4 80.0 257 CYS -87.1 141.5 176.9 -169.0 258 SER -125.4 -29.7 -174.7 50.8 259 HIS -100.2 132.6 -176.9 -74.1 55.0 260 TYR -139.3 157.7 176.7 -60.9 84.6 261 MET -159.8 136.7 174.4 -174.6 167.8 63.1 262 LYS -58.0 138.8 173.5 -171.3 166.2 172.0 -150.9 263 ASN -66.8 125.3 -169.5 -176.5 -42.2 264 PHE -65.6 -30.4 -175.4 -170.7 88.0 265 ASP -88.3 -10.9 179.7 -68.5 -38.9 266 VAL -80.1 132.9 -177.2 -179.5 267 GLY -91.5 -167.4 172.0 268 HIS -53.9 130.3 174.2 170.4 77.0 269 VAL -125.3 117.1 175.4 -178.3 270 PRO -67.7 125.3 -180.0 -13.0 26.3 271 ILE -127.5 131.0 175.4 -65.0 -179.2 272 ARG -100.2 -26.7 177.0 -65.4 150.6 -84.6 173.4 273 LEU -53.9 121.3 -162.4 -61.9 170.8 274 PRO -66.7 -44.9 -178.0 -11.3 9.1 275 ARG -72.1 -34.9 177.1 -61.8 168.1 -157.6 151.5 276 THR -69.5 -42.6 174.7 -55.4 277 LYS -60.9 -45.2 178.9 177.6 -172.8 -163.3 70.0 278 HIS -62.2 -44.5 -179.2 173.6 72.8 279 LEU -62.9 -42.8 177.0 -179.9 63.0 280 LEU -61.6 -36.8 175.0 -178.7 52.5 281 ASN -64.9 -41.3 176.0 -72.5 -18.9 282 VAL -58.3 -42.9 -178.1 171.5 283 ILE -66.6 -44.6 -176.0 -70.2 159.6 284 ASN -65.9 -38.2 -179.7 -74.4 -25.3 285 GLU -70.9 -36.4 -167.0 -64.5 172.1 24.2 286 ASN -102.8 -33.1 -175.6 -72.5 -88.6 287 PHE -119.0 -27.4 -170.7 -47.0 -61.5 288 GLY 55.7 -122.4 177.5 289 THR -95.2 7.3 176.6 51.8 290 LEU -81.3 151.5 -177.7 -62.9 168.0 291 ALA -72.8 154.9 177.2 292 PHE -142.2 174.5 175.4 56.8 -83.8 293 CYS -133.7 173.2 -179.2 63.9 294 ARG -64.7 -35.8 175.9 -68.4 155.4 55.4 167.1 295 ARG -59.5 -34.8 179.1 -76.5 -175.4 -59.5 103.4 296 TRP -70.5 -24.8 171.5 -70.4 4.5 297 LEU -76.9 -38.7 178.1 -64.2 173.4 298 ASP -58.2 -41.9 -176.0 -59.3 -25.8 299 ARG -69.5 -21.9 172.7 68.2 -176.4 -69.3 -75.7 300 LEU -83.6 4.4 177.3 -60.2 168.2 301 GLY 87.8 9.5 177.1 302 GLU -78.5 142.3 172.0 -60.5 -62.7 -39.6 303 SER -144.8 162.8 179.6 58.2 304 LYS 58.1 46.8 -176.9 -61.3 -179.3 -75.6 172.4 305 TYR -112.9 -4.8 -167.0 58.9 76.3 306 LEU -70.5 -37.6 175.3 -69.6 167.8 307 MET -67.9 -39.2 174.8 -168.7 62.5 57.4 308 ALA -60.4 -39.1 179.0 309 LEU -67.4 -39.2 174.4 -174.4 57.7 310 LYS -62.7 -41.6 176.7 -173.3 177.2 -171.2 -63.5 311 ASN -58.8 -43.3 177.1 -71.6 -13.7 312 LEU -67.7 -30.9 174.1 -62.7 172.2 313 CYS -70.5 -42.6 -180.0 -68.2 314 ASP -67.3 -31.1 173.0 -70.4 -19.6 315 LEU -74.3 -12.0 -175.4 -68.8 166.4 316 GLY 77.0 12.6 178.7 317 ILE -77.8 -39.3 177.4 -64.8 167.2 318 VAL -117.9 144.4 173.4 173.7 319 ASP -111.4 136.1 171.2 -59.6 -50.0 320 PRO -82.7 145.3 177.7 31.9 -32.5 321 TYR -128.9 85.1 -176.0 -75.7 88.5 322 PRO -70.9 162.5 175.3 24.4 -32.2 323 PRO -54.7 140.7 -177.4 -21.1 33.7 324 LEU -112.5 113.9 -167.7 -59.1 173.9 325 CYS -128.4 145.5 170.4 -48.3 326 ASP -85.2 -173.2 -173.4 -158.2 -35.8 327 ILE -66.6 156.3 179.3 60.9 178.2 328 LYS -58.7 135.3 -179.8 -160.5 -76.9 -153.9 57.6 329 GLY 96.4 -12.9 -179.3 330 SER -85.9 160.5 178.8 66.8 331 TYR -118.0 132.2 -178.4 -56.3 -64.1 332 THR -127.2 146.1 178.9 65.3 333 ALA -135.2 155.3 -175.8 334 GLN -144.9 138.1 164.2 177.9 -162.0 16.9 335 PHE -133.5 148.8 -173.6 -75.2 -89.6 336 GLU -155.0 144.4 168.5 176.4 -171.5 40.3 337 HIS -133.8 158.0 169.2 -85.2 -56.8 338 THR -97.8 132.9 -179.2 -66.2 339 ILE -122.0 143.1 175.3 64.8 169.3 340 LEU -106.0 127.4 175.6 -45.8 173.3 341 LEU -91.5 79.7 -177.6 -56.5 -175.4 342 ARG -76.7 158.3 176.9 -73.3 168.4 44.3 -148.6 343 PRO -58.7 -35.8 -175.0 -26.3 36.6 344 THR -93.5 -11.7 -168.9 61.1 345 CYS 177.9 163.3 175.3 69.4 346 LYS -95.7 130.6 -178.6 165.9 173.0 61.7 179.1 347 GLU -116.0 115.3 172.6 -173.9 172.7 -18.3 348 VAL -83.3 86.6 -161.6 -167.7 349 VAL -71.6 -28.6 -178.7 67.7 350 SER -94.4 6.1 177.1 56.4 351 ARG -59.9 139.6 173.3 -178.0 75.0 74.3 -172.7 352 GLY -126.8 -169.3 171.7 353 ASP -85.1 -4.4 179.5 67.0 7.2 354 ASP -91.9 -49.3 176.4 47.0 1.0 355 TYR -158.6 169.0 0.0 65.7 -81.3 Alpha Carbon Cartesian Coordinates : Residue Type X Y Z 1 LYS 37.205 15.571 -7.486 2 VAL 38.007 13.979 -4.140 3 GLN 37.875 16.282 -1.099 4 THR 41.261 17.773 -0.199 5 ASP 43.421 17.292 2.890 6 PRO 41.990 20.343 4.565 7 PRO 38.654 20.703 2.808 8 SER 38.545 23.230 -0.024 9 VAL 36.421 21.582 -2.738 10 PRO 32.806 22.769 -2.784 11 ILE 30.249 20.004 -2.179 12 CYS 28.630 20.708 -5.546 13 ASP 31.944 19.854 -7.283 14 LEU 32.165 16.558 -5.370 15 TYR 28.724 15.514 -6.667 16 PRO 28.741 16.808 -10.239 17 ASN 25.391 15.206 -11.136 18 GLY 23.775 17.481 -8.523 19 VAL 22.398 14.578 -6.483 20 PHE 23.626 14.708 -2.883 21 PRO 23.867 11.979 -0.235 22 LYS 20.795 11.131 1.847 23 GLY 20.930 11.337 5.620 24 GLN 19.762 8.529 7.887 25 GLU 16.326 7.400 6.694 26 CYS 13.990 6.026 9.347 27 GLU 10.547 4.466 9.374 28 TYR 8.086 6.601 11.334 29 PRO 7.346 5.513 14.831 30 GLU 1.858 5.149 -4.470 31 GLU 0.558 8.615 -3.624 32 LYS 3.019 9.511 -0.865 33 LYS 5.982 8.216 -2.883 34 ALA 4.872 10.508 -5.714 35 LEU 4.477 13.384 -3.248 36 ASP 7.930 12.702 -1.795 37 GLN 9.464 12.680 -5.288 38 ALA 7.717 15.955 -6.194 39 SER 9.817 17.775 -3.581 40 GLU 13.072 16.013 -4.473 41 GLU 14.800 19.289 -5.434 42 ILE 14.081 20.628 -1.920 43 TRP 15.401 17.527 -0.157 44 ASN 18.477 17.633 -2.390 45 ASP 19.181 21.227 -1.322 46 PHE 19.028 20.227 2.350 47 ARG 21.329 17.292 1.591 48 GLU 23.896 19.558 -0.098 49 ALA 23.860 21.844 2.950 50 ALA 24.081 18.846 5.284 51 GLU 27.085 17.387 3.495 52 ALA 28.826 20.765 3.835 53 HIS 27.950 20.702 7.554 54 ARG 29.359 17.193 7.996 55 GLN 32.641 18.059 6.251 56 VAL 33.090 21.396 8.079 57 ARG 32.464 19.887 11.526 58 LYS 34.832 16.947 10.916 59 TYR 37.493 19.519 10.013 60 VAL 36.701 21.620 13.115 61 MET 36.988 18.591 15.437 62 SER 40.471 17.943 14.021 63 TRP 41.918 21.303 15.111 64 ILE 39.789 22.909 17.825 65 LYS 42.039 23.145 20.910 66 PRO 42.389 25.158 24.118 67 GLY 44.661 28.165 23.595 68 MET 42.840 29.338 20.464 69 THR 40.788 32.500 20.744 70 MET 37.076 32.229 20.116 71 ILE 37.491 34.636 17.202 72 GLU 40.148 32.394 15.636 73 ILE 37.869 29.353 16.011 74 CYS 34.845 31.046 14.438 75 GLU 36.803 32.567 11.564 76 LYS 38.529 29.290 10.705 77 LEU 35.204 27.427 10.794 78 GLU 33.354 30.062 8.742 79 ASP 36.112 30.206 6.140 80 CYS 35.704 26.483 5.533 81 SER 31.921 26.694 5.478 82 ARG 31.940 29.505 2.890 83 LYS 34.214 27.448 0.627 84 LEU 32.369 24.143 0.944 85 ILE 28.877 25.641 0.526 86 LYS 30.155 27.726 -2.405 87 GLU 28.823 30.948 -0.926 88 ASN 26.744 32.870 -3.467 89 GLY 24.771 35.771 -2.002 90 LEU 21.408 34.520 -0.741 91 ASN 21.422 31.423 -2.964 92 ALA 24.004 29.498 -0.905 93 GLY 25.790 30.474 2.279 94 LEU 25.941 30.549 6.052 95 ALA 22.473 30.376 7.568 96 PHE 23.407 31.960 10.907 97 PRO 26.478 32.887 12.947 98 THR 28.780 30.311 14.481 99 GLY 27.766 29.715 18.077 100 CYS 30.589 28.738 20.412 101 SER 28.896 29.299 23.763 102 LEU 31.002 28.382 26.785 103 ASN 30.342 26.747 30.175 104 ASN 27.143 28.128 31.755 105 CYS 26.292 29.877 28.464 106 ALA 24.192 27.532 26.379 107 ALA 23.392 29.393 23.160 108 HIS 23.768 32.520 21.055 109 TYR 27.316 33.561 21.935 110 THR 29.733 34.327 19.120 111 PRO 32.576 36.796 19.712 112 ASN 32.291 40.395 18.622 113 ALA 35.295 42.373 17.437 114 GLY 37.893 42.757 20.151 115 ASP 36.798 39.779 22.279 116 THR 39.936 38.309 23.792 117 THR 38.296 35.163 25.173 118 VAL 40.522 32.097 24.888 119 LEU 39.235 28.518 24.894 120 GLN 40.382 26.662 28.034 121 TYR 41.037 23.013 28.884 122 ASP 38.092 22.848 31.286 123 ASP 35.695 24.642 28.928 124 ILE 32.550 23.046 27.564 125 CYS 31.914 24.688 24.190 126 LYS 28.766 24.348 22.105 127 ILE 29.529 24.592 18.402 128 ASP 26.287 25.480 16.609 129 PHE 26.492 26.558 12.982 130 GLY 24.241 26.521 9.966 131 THR 24.555 26.156 6.220 132 HIS 21.884 26.604 3.551 133 ILE 21.257 26.108 -0.153 134 SER 18.421 28.254 -1.557 135 GLY 17.226 28.983 1.988 136 ARG 17.004 25.288 2.939 137 ILE 18.747 25.476 6.295 138 ILE 20.669 22.897 8.306 139 ASP 20.883 23.689 12.027 140 CYS 23.155 21.102 13.644 141 ALA 25.252 21.333 16.786 142 PHE 27.593 19.417 19.054 143 THR 29.576 19.987 22.247 144 VAL 33.362 20.168 22.427 145 THR 35.245 19.256 25.582 146 PHE 38.814 18.296 26.426 147 ASN 38.462 17.111 30.024 148 PRO 36.841 13.674 30.370 149 LYS 35.014 14.826 33.517 150 TYR 32.164 16.024 31.274 151 ASP 31.753 12.766 29.350 152 THR 28.563 11.589 31.068 153 LEU 26.961 15.028 30.764 154 LEU 27.634 14.910 26.995 155 LYS 26.309 11.354 26.750 156 ALA 23.125 12.370 28.574 157 VAL 22.405 15.200 26.165 158 LYS 23.367 13.184 23.080 159 ASP 21.037 10.373 24.204 160 ALA 18.243 12.891 24.889 161 THR 18.597 14.428 21.394 162 ASN 18.560 10.988 19.795 163 THR 15.481 10.164 21.867 164 GLY 13.720 13.282 20.570 165 ILE 14.755 12.348 16.992 166 LYS 13.386 8.809 17.432 167 CYS 10.123 10.105 18.937 168 ALA 9.512 12.687 16.199 169 GLY 7.175 11.876 13.337 170 ILE 4.119 12.893 11.368 171 ASP 1.121 13.276 13.704 172 VAL 3.295 13.065 16.832 173 ARG 2.413 15.554 19.585 174 LEU 5.220 18.040 20.321 175 CYS 4.537 17.720 24.076 176 ASP 5.206 13.970 23.878 177 VAL 8.596 14.588 22.290 178 GLY 9.410 16.945 25.187 179 GLU 8.335 14.439 27.847 180 ALA 10.405 11.693 26.198 181 ILE 13.522 13.856 25.974 182 GLN 13.257 14.845 29.650 183 GLU 12.762 11.249 30.818 184 VAL 15.981 10.153 29.123 185 MET 17.995 13.236 30.093 186 GLU 17.029 13.021 33.781 187 SER 17.959 9.316 33.897 188 TYR 21.613 10.438 33.926 189 GLU 23.628 11.418 36.964 190 VAL 27.076 12.966 36.661 191 GLU 29.963 13.765 39.001 192 ILE 32.117 16.800 38.215 193 ASP 34.856 17.956 40.596 194 GLY 33.505 15.950 43.516 195 LYS 29.892 17.187 43.228 196 THR 27.080 15.015 41.871 197 TYR 24.248 16.238 39.712 198 GLN 21.113 14.825 38.094 199 VAL 21.255 16.275 34.559 200 LYS 18.442 18.786 33.973 201 PRO 16.978 19.819 30.619 202 ILE 17.058 23.595 30.160 203 ARG 13.336 24.099 30.397 204 ASN 13.143 27.436 28.551 205 LEU 15.164 26.323 25.541 206 ASN 13.511 24.515 22.666 207 GLY 13.907 22.998 19.245 208 HIS 11.972 24.545 16.405 209 SER 10.528 24.054 12.968 210 ILE 12.463 25.452 10.035 211 GLY 11.158 27.221 6.940 212 GLN 12.636 28.683 3.771 213 TYR 15.052 31.421 4.873 214 ARG 13.379 31.094 8.265 215 ILE 15.446 29.465 10.976 216 HIS 12.469 29.484 13.357 217 ALA 9.249 28.858 11.444 218 GLY 7.076 29.179 14.539 219 LYS 6.564 25.693 16.008 220 THR 8.602 24.902 19.106 221 VAL 9.810 21.477 20.232 222 PRO 9.898 21.359 24.051 223 ILE 12.571 19.470 25.957 224 VAL 10.546 19.041 29.148 225 LYS 7.024 17.831 29.843 226 GLY 4.048 20.149 29.919 227 GLY 4.198 21.713 26.442 228 GLU 1.573 22.013 23.688 229 ALA -0.084 18.988 22.082 230 THR 0.253 20.591 18.620 231 ARG 1.190 17.857 16.131 232 MET 4.099 17.591 13.706 233 GLU 2.988 17.593 10.068 234 GLU 4.066 16.000 6.804 235 GLY 6.606 18.078 4.914 236 GLU 7.798 20.043 7.944 237 VAL 11.448 20.287 8.860 238 TYR 12.588 20.452 12.464 239 ALA 15.727 21.233 14.407 240 ILE 15.626 18.716 17.236 241 GLU 17.985 20.109 19.826 242 THR 18.368 19.387 23.501 243 PHE 20.324 21.207 26.184 244 GLY 21.322 19.740 29.558 245 SER 22.653 21.617 32.575 246 THR 24.106 21.162 36.032 247 GLY 22.687 24.554 37.159 248 LYS 19.097 25.731 37.555 249 GLY 18.021 24.390 34.176 250 VAL 16.849 27.876 33.127 251 VAL 18.659 30.437 30.987 252 HIS 18.586 34.223 31.136 253 ASP 19.984 36.866 28.767 254 ASP 23.590 37.705 29.634 255 MET 26.753 39.288 28.233 256 GLU 27.043 41.487 25.161 257 CYS 24.782 40.751 22.199 258 SER 26.322 39.438 18.962 259 HIS 23.414 37.782 17.114 260 TYR 20.666 39.714 15.273 261 MET 18.018 38.827 12.662 262 LYS 15.374 40.734 10.715 263 ASN 11.839 40.050 11.918 264 PHE 10.445 37.767 9.220 265 ASP 7.004 39.350 9.335 266 VAL 8.118 42.986 9.052 267 GLY 7.667 44.341 5.543 268 HIS 9.372 47.248 3.802 269 VAL 9.951 50.260 6.033 270 PRO 10.979 53.554 4.427 271 ILE 13.882 55.057 6.353 272 ARG 15.428 58.480 5.775 273 LEU 18.017 58.519 8.598 274 PRO 21.136 57.960 6.504 275 ARG 23.233 55.512 8.547 276 THR 20.145 53.501 9.577 277 LYS 18.881 53.371 5.978 278 HIS 22.293 52.224 4.752 279 LEU 22.614 49.497 7.399 280 LEU 19.120 48.171 6.630 281 ASN 20.059 48.025 2.935 282 VAL 23.242 46.098 3.824 283 ILE 21.183 43.638 5.885 284 ASN 18.558 43.171 3.177 285 GLU 21.203 42.603 0.485 286 ASN 23.472 40.232 2.425 287 PHE 21.273 38.404 4.921 288 GLY 17.583 38.995 4.142 289 THR 15.753 37.146 6.915 290 LEU 18.767 35.005 7.892 291 ALA 20.539 35.748 11.176 292 PHE 23.803 37.655 11.222 293 CYS 26.328 38.935 13.721 294 ARG 28.425 42.038 14.294 295 ARG 31.556 40.340 12.904 296 TRP 29.689 39.763 9.633 297 LEU 28.974 43.485 9.317 298 ASP 32.632 44.278 10.040 299 ARG 33.755 41.945 7.239 300 LEU 31.567 43.842 4.741 301 GLY 33.461 47.039 5.591 302 GLU 30.767 48.567 7.790 303 SER 31.783 50.756 10.705 304 LYS 29.921 53.189 12.967 305 TYR 26.887 50.945 12.699 306 LEU 26.038 50.219 16.333 307 MET 23.646 53.128 16.738 308 ALA 22.007 52.294 13.387 309 LEU 21.677 48.685 14.561 310 LYS 20.152 49.816 17.859 311 ASN 17.717 51.956 15.876 312 LEU 16.604 48.996 13.772 313 CYS 16.115 46.942 16.944 314 ASP 14.137 49.745 18.627 315 LEU 11.951 50.034 15.494 316 GLY 11.313 46.264 15.670 317 ILE 12.764 45.715 12.182 318 VAL 15.636 43.677 13.637 319 ASP 15.574 41.557 16.796 320 PRO 18.600 41.023 19.031 321 TYR 19.298 37.504 20.316 322 PRO 21.666 37.821 23.277 323 PRO 23.612 34.930 24.797 324 LEU 21.450 32.615 26.897 325 CYS 23.151 31.425 30.083 326 ASP 22.395 29.380 33.217 327 ILE 23.814 30.409 36.604 328 LYS 27.495 31.133 37.143 329 GLY 29.412 27.918 37.817 330 SER 27.010 25.685 35.895 331 TYR 27.848 23.482 32.913 332 THR 25.640 23.172 29.825 333 ALA 25.798 20.836 26.797 334 GLN 23.873 20.668 23.485 335 PHE 23.383 18.270 20.562 336 GLU 21.097 18.953 17.603 337 HIS 20.121 17.566 14.206 338 THR 17.837 18.745 11.414 339 ILE 15.153 16.253 10.415 340 LEU 12.924 16.196 7.338 341 LEU 9.399 14.802 7.710 342 ARG 9.211 13.394 4.193 343 PRO 6.073 11.617 3.012 344 THR 7.828 8.214 2.795 345 CYS 10.092 8.362 5.844 346 LYS 11.821 10.548 8.432 347 GLU 15.265 11.688 7.291 348 VAL 17.887 12.742 9.841 349 VAL 19.534 14.738 7.115 350 SER 22.423 16.072 9.188 351 ARG 23.313 12.685 10.729 352 GLY 26.985 11.736 10.358 353 ASP 29.369 9.014 11.426 354 ASP 30.337 11.332 14.311 355 TYR 26.918 11.978 15.911 Richards-Kundrot Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 C C C T T T T C C H 10 H H H H H H C S S S 20 S S S S/S S S S S C/X X/H 30 H H H H H H H H H H/H 40 H H H H H H H H H H 50 H H H H H H H H H H 60 H H H H/S S S S C H H 70 H H H H H H H H H H 80 H H H H H H C T T T 90 T/S S S S S S S S/S S S 100 S S/T T T T C S S S S 110 S C C C C S S S S S 120 S S S S S S S S S S 130 S S/T T T T/S S S S S S 140 S S S S S S S C C H 150 H H H H H H H H H H 160 H H H H H H H H C C 170 C C H H H H H H H H 180 H H H H H H H/S S S S 190 S/T T T T/S S S S S S/S S 200 S S C S S S S S S S 210 S/T T T T C C C S S S 220 S S S/S S S S/S S S S/S S 230 S S S S S/S S S S S S 240 S S S S S S C C S S 250 S S S S S S/S S S S/S S 260 S S S C S S S S/S S S 270 S S H H H H H H H H 280 H H H H H H H/T T T T/S 290 S S S/H H H H H H H H 300 H/S S S S H H H H H H 310 H H H H H H S S S S 320 S S S/S S S S S C S S 330 S S S S/S S S S S S S 340 S S/T T T T/S S S S C S 350 S S S/S S S Kabsch-Sander Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 S S S h 10 H H H H h T T t 20 E E E h 30 H H H H H H H H h H 40 H H H H H H H H H H 50 H H H H H H H H H H 60 H H H h t T T t h H 70 H H H H H H H H H H 80 H H H H H h t B T T 90 e E E E E E E E E E 100 E E e e E E E 110 t T T t B t 120 T T t e E E E E E E 130 E E E e T E E E E E 140 E E E E S g G G h 150 H H H H H H H H H H 160 H H H H H H H h t T 170 T t h H H H H H H H 180 H H H H H H h e E E 190 E E T T E E E E e E 200 E e T T e E E E E E 210 B T T B S S e E 220 E E e S S S 230 B t T T e E E E E 240 E E E E E e S S 250 E E e S e E E 260 E E e T T t 270 h H H H H H H H 280 H H H H H H h T T t 290 E E H H H H H H h 300 T t S h H H H H H 310 H H H H h T e E E E 320 E e E E e t T T t 330 e E E E E E E E E E 340 E e S S e E E E e T 350 t S Buried Surface Area Percentages : Residue Type Buried Area % Buried % Polar Cover 1 LYS 0.0 0.0 89.7 2 VAL 0.0 0.0 84.2 3 GLN 122.6 82.5 54.7 4 THR 53.0 49.6 75.5 5 ASP 0.0 0.0 78.1 6 PRO 43.3 34.8 67.2 7 PRO 112.7 90.5 47.1 8 SER 39.5 47.2 64.1 9 VAL 95.9 80.7 56.9 10 PRO 101.0 81.1 58.8 11 ILE 143.5 100.0 41.8 12 CYS 67.6 68.2 62.2 13 ASP 53.3 48.3 67.2 14 LEU 135.7 91.8 58.3 15 TYR 119.6 66.1 58.3 16 PRO 41.3 33.2 88.5 17 ASN 27.8 23.0 71.0 18 GLY 9.8 28.3 69.4 19 VAL 19.9 16.7 82.3 20 PHE 158.9 95.3 50.2 21 PRO 83.2 66.8 64.7 22 LYS 89.4 51.6 85.5 23 GLY 31.9 91.7 69.3 24 GLN 71.8 48.3 66.4 25 GLU 89.6 64.7 65.1 26 CYS 70.9 71.5 67.2 27 GLU 0.0 0.0 89.3 28 TYR 144.3 79.7 55.8 29 PRO 73.0 58.6 63.9 30 GLU 0.0 0.0 91.0 31 GLU 12.9 9.3 77.8 32 LYS 73.4 42.3 78.1 33 LYS 30.2 17.4 80.4 34 ALA 14.6 20.2 78.7 35 LEU 60.5 40.9 71.7 36 ASP 105.4 95.4 58.6 37 GLN 38.7 26.0 79.7 38 ALA 18.9 26.0 80.0 39 SER 51.9 62.0 61.4 40 GLU 86.5 62.4 76.3 41 GLU 0.0 0.0 84.8 42 ILE 88.8 61.9 63.2 43 TRP 194.4 94.8 50.4 44 ASN 95.8 79.2 62.3 45 ASP 78.8 71.3 63.8 46 PHE 160.4 96.1 34.2 47 ARG 205.1 98.2 56.6 48 GLU 123.0 88.7 40.3 49 ALA 72.6 100.0 54.3 50 ALA 72.6 100.0 50.9 51 GLU 118.9 85.8 56.9 52 ALA 72.6 100.0 42.1 53 HIS 150.2 100.0 47.4 54 ARG 174.7 83.6 68.7 55 GLN 131.5 88.5 52.3 56 VAL 118.8 100.0 37.1 57 ARG 208.9 100.0 42.4 58 LYS 46.2 26.6 79.5 59 TYR 143.9 79.5 50.0 60 VAL 118.8 100.0 26.0 61 MET 105.9 66.4 51.6 62 SER 23.9 28.6 75.7 63 TRP 173.6 84.7 44.5 64 ILE 139.1 96.9 25.1 65 LYS 63.7 36.7 69.5 66 PRO 94.5 75.9 45.3 67 GLY 4.0 11.5 74.4 68 MET 121.0 75.9 58.4 69 THR 73.6 68.9 65.4 70 MET 158.8 99.6 34.3 71 ILE 108.2 75.4 62.2 72 GLU 52.2 37.6 69.2 73 ILE 143.5 100.0 27.9 74 CYS 99.2 100.0 53.4 75 GLU 51.9 37.5 73.2 76 LYS 90.4 52.1 63.4 77 LEU 146.8 99.3 31.5 78 GLU 135.1 97.5 61.7 79 ASP 42.2 38.2 78.5 80 CYS 93.6 94.4 42.2 81 SER 82.5 98.6 35.6 82 ARG 176.5 84.5 60.1 83 LYS 60.7 35.0 79.6 84 LEU 147.8 100.0 49.2 85 ILE 143.4 100.0 46.1 86 LYS 64.0 36.9 75.4 87 GLU 88.5 63.9 65.0 88 ASN 32.1 26.6 80.1 89 GLY 0.0 0.0 83.8 90 LEU 92.5 62.6 72.1 91 ASN 31.6 26.2 83.4 92 ALA 63.3 87.2 60.1 93 GLY 32.4 93.2 49.2 94 LEU 139.2 94.2 52.1 95 ALA 72.6 100.0 39.5 96 PHE 147.5 88.4 51.7 97 PRO 124.5 100.0 39.2 98 THR 105.3 98.5 41.9 99 GLY 30.5 87.8 71.0 100 CYS 99.2 100.0 36.6 101 SER 82.2 98.3 54.3 102 LEU 127.4 86.2 49.6 103 ASN 79.2 65.5 67.3 104 ASN 89.2 73.8 65.1 105 CYS 94.7 95.4 52.1 106 ALA 72.6 99.9 37.4 107 ALA 58.6 80.7 50.8 108 HIS 89.3 59.5 56.1 109 TYR 160.2 88.5 46.0 110 THR 106.9 100.0 44.5 111 PRO 124.4 99.9 44.8 112 ASN 111.6 92.3 61.4 113 ALA 19.8 27.2 76.7 114 GLY 0.0 0.0 80.1 115 ASP 77.1 69.8 67.0 116 THR 2.2 2.0 89.6 117 THR 56.1 52.4 70.5 118 VAL 72.9 61.4 71.9 119 LEU 147.6 99.8 35.5 120 GLN 55.0 37.0 73.0 121 TYR 75.9 41.9 67.8 122 ASP 48.9 44.3 71.6 123 ASP 99.5 90.1 56.3 124 ILE 143.5 100.0 37.7 125 CYS 98.9 99.7 34.8 126 LYS 172.0 99.2 60.5 127 ILE 143.5 100.0 27.6 128 ASP 85.0 76.9 68.0 129 PHE 163.2 97.8 42.1 130 GLY 34.8 100.0 48.9 131 THR 106.9 100.0 40.1 132 HIS 148.4 98.8 44.9 133 ILE 127.6 88.9 61.7 134 SER 46.2 55.3 76.3 135 GLY 34.8 100.0 42.6 136 ARG 160.8 77.0 53.3 137 ILE 143.5 100.0 38.6 138 ILE 143.5 100.0 40.1 139 ASP 103.0 93.2 52.7 140 CYS 99.2 100.0 57.7 141 ALA 72.6 100.0 63.2 142 PHE 160.9 96.4 32.8 143 THR 106.9 100.0 36.4 144 VAL 106.1 89.3 34.4 145 THR 96.9 90.6 44.7 146 PHE 134.1 80.4 50.2 147 ASN 98.2 81.2 52.0 148 PRO 41.3 33.2 89.3 149 LYS 129.8 74.8 67.7 150 TYR 180.2 99.6 38.8 151 ASP 32.8 29.7 75.1 152 THR 63.9 59.8 61.7 153 LEU 147.8 100.0 31.1 154 LEU 125.1 84.6 48.0 155 LYS 61.5 35.5 72.8 156 ALA 72.6 100.0 39.3 157 VAL 118.8 100.0 48.6 158 LYS 94.9 54.7 63.2 159 ASP 58.2 52.6 68.5 160 ALA 72.6 100.0 47.7 161 THR 104.7 98.0 53.7 162 ASN 74.1 61.3 67.5 163 THR 84.9 79.5 51.6 164 GLY 34.8 100.0 47.1 165 ILE 139.2 97.0 41.9 166 LYS 14.6 8.4 85.7 167 CYS 63.8 64.3 53.9 168 ALA 72.6 100.0 37.1 169 GLY 34.4 98.9 33.4 170 ILE 110.1 76.7 58.6 171 ASP 23.5 21.3 74.2 172 VAL 89.2 75.1 57.9 173 ARG 110.8 53.0 73.9 174 LEU 143.8 97.3 44.2 175 CYS 80.6 81.3 64.4 176 ASP 59.2 53.6 67.0 177 VAL 118.8 100.0 36.6 178 GLY 34.8 100.0 58.7 179 GLU 51.3 37.0 76.0 180 ALA 51.0 70.3 59.5 181 ILE 143.3 99.9 39.0 182 GLN 122.6 82.5 52.6 183 GLU 13.8 9.9 82.0 184 VAL 83.2 70.1 65.6 185 MET 159.4 100.0 40.6 186 GLU 91.9 66.3 70.7 187 SER 26.5 31.7 75.0 188 TYR 147.0 81.2 60.7 189 GLU 13.4 9.7 80.7 190 VAL 114.4 96.3 39.2 191 GLU 51.4 37.1 69.0 192 ILE 142.5 99.3 37.0 193 ASP 35.2 31.8 79.5 194 GLY 4.9 14.0 79.6 195 LYS 44.5 25.6 82.5 196 THR 28.7 26.9 72.6 197 TYR 133.6 73.8 59.0 198 GLN 58.1 39.1 76.1 199 VAL 118.8 100.0 40.2 200 LYS 88.0 50.7 75.6 201 PRO 122.0 98.0 44.6 202 ILE 143.5 100.0 39.9 203 ARG 73.3 35.1 71.1 204 ASN 62.9 52.0 65.2 205 LEU 132.2 89.5 36.8 206 ASN 77.2 63.9 67.8 207 GLY 34.8 99.9 59.7 208 HIS 133.9 89.2 56.8 209 SER 77.4 92.6 53.1 210 ILE 142.8 99.5 49.9 211 GLY 14.9 42.8 61.4 212 GLN 81.3 54.7 73.7 213 TYR 127.6 70.5 58.5 214 ARG 137.8 66.0 63.3 215 ILE 122.3 85.2 35.0 216 HIS 83.0 55.2 62.9 217 ALA 56.9 78.4 66.3 218 GLY 9.0 25.7 79.2 219 LYS 132.6 76.5 65.1 220 THR 55.5 51.9 72.7 221 VAL 118.0 99.4 35.9 222 PRO 111.5 89.5 62.3 223 ILE 143.4 99.9 48.1 224 VAL 91.2 76.8 60.1 225 LYS 55.6 32.1 80.1 226 GLY 0.0 0.0 79.8 227 GLY 16.6 47.7 61.8 228 GLU 15.4 11.1 85.9 229 ALA 37.3 51.3 72.0 230 THR 54.5 51.0 64.8 231 ARG 92.2 44.1 77.4 232 MET 159.4 100.0 35.3 233 GLU 43.4 31.3 76.3 234 GLU 104.1 75.1 47.8 235 GLY 16.2 46.5 67.4 236 GLU 100.2 72.3 57.9 237 VAL 110.0 92.6 42.1 238 TYR 181.0 100.0 32.9 239 ALA 72.6 100.0 56.9 240 ILE 143.4 99.9 31.2 241 GLU 126.6 91.3 56.2 242 THR 106.9 100.0 36.2 243 PHE 161.1 96.6 41.9 244 GLY 34.8 100.0 40.9 245 SER 83.6 100.0 49.8 246 THR 105.1 98.3 38.5 247 GLY 31.4 90.2 62.4 248 LYS 57.6 33.2 73.3 249 GLY 33.3 95.8 57.7 250 VAL 80.5 67.7 69.1 251 VAL 116.4 98.0 43.2 252 HIS 60.5 40.3 74.8 253 ASP 39.0 35.3 64.0 254 ASP 52.9 47.9 70.6 255 MET 75.2 47.2 62.6 256 GLU 38.3 27.6 84.8 257 CYS 81.6 82.2 58.3 258 SER 82.1 98.2 61.1 259 HIS 137.5 91.6 47.8 260 TYR 167.1 92.3 37.3 261 MET 133.7 83.9 53.3 262 LYS 143.1 82.5 56.0 263 ASN 70.9 58.6 75.5 264 PHE 102.7 61.6 73.4 265 ASP 24.9 22.5 85.2 266 VAL 81.3 68.4 67.5 267 GLY 0.0 0.0 85.0 268 HIS 18.6 12.4 79.1 269 VAL 75.4 63.5 50.6 270 PRO 38.8 31.2 75.7 271 ILE 132.7 92.5 39.9 272 ARG 5.4 2.6 88.9 273 LEU 42.9 29.0 70.6 274 PRO 23.4 18.8 76.5 275 ARG 29.1 13.9 82.7 276 THR 104.4 97.6 39.8 277 LYS 74.6 43.0 75.8 278 HIS 59.2 39.4 75.4 279 LEU 145.8 98.6 33.7 280 LEU 136.1 92.1 46.2 281 ASN 54.5 45.1 72.9 282 VAL 105.6 88.9 49.7 283 ILE 143.5 100.0 31.7 284 ASN 75.0 62.0 65.3 285 GLU 30.2 21.8 79.7 286 ASN 79.0 65.3 50.7 287 PHE 149.0 89.3 40.8 288 GLY 19.2 55.0 68.6 289 THR 81.0 75.8 60.1 290 LEU 141.5 95.7 49.2 291 ALA 62.4 85.9 42.5 292 PHE 166.8 100.0 25.9 293 CYS 99.1 99.9 42.8 294 ARG 172.2 82.5 53.7 295 ARG 191.9 91.8 54.1 296 TRP 194.4 94.8 51.7 297 LEU 147.8 100.0 27.3 298 ASP 70.5 63.8 68.5 299 ARG 101.9 48.8 75.9 300 LEU 105.8 71.6 66.3 301 GLY 0.0 0.0 87.5 302 GLU 114.0 82.3 47.6 303 SER 21.1 25.3 69.0 304 LYS 10.9 6.3 89.3 305 TYR 162.5 89.8 47.4 306 LEU 62.2 42.1 74.5 307 MET 33.0 20.7 82.1 308 ALA 71.3 98.3 53.4 309 LEU 144.4 97.7 28.3 310 LYS 57.5 33.2 77.6 311 ASN 78.7 65.1 58.4 312 LEU 147.8 100.0 31.1 313 CYS 85.5 86.1 50.5 314 ASP 40.3 36.5 80.3 315 LEU 70.1 47.4 61.5 316 GLY 8.4 24.1 86.5 317 ILE 140.4 97.8 24.1 318 VAL 118.8 100.0 34.4 319 ASP 68.7 62.2 62.3 320 PRO 71.6 57.5 52.7 321 TYR 106.8 59.0 54.8 322 PRO 93.6 75.2 60.2 323 PRO 124.3 99.8 47.5 324 LEU 115.6 78.2 53.1 325 CYS 97.8 98.6 54.3 326 ASP 110.5 100.0 50.2 327 ILE 59.2 41.3 68.2 328 LYS 6.3 3.6 88.2 329 GLY 0.2 0.6 75.4 330 SER 79.9 95.6 55.1 331 TYR 137.6 76.0 57.4 332 THR 106.8 99.9 52.7 333 ALA 72.6 100.0 35.7 334 GLN 146.4 98.5 45.1 335 PHE 157.8 94.6 41.5 336 GLU 138.6 100.0 57.6 337 HIS 148.3 98.7 47.3 338 THR 106.9 100.0 42.2 339 ILE 143.5 100.0 29.4 340 LEU 147.8 100.0 31.8 341 LEU 147.8 100.0 41.9 342 ARG 195.3 93.5 54.5 343 PRO 119.1 95.7 45.9 344 THR 69.0 64.6 61.6 345 CYS 84.3 85.0 62.9 346 LYS 169.3 97.6 44.6 347 GLU 138.6 100.0 46.4 348 VAL 118.8 100.0 42.3 349 VAL 118.7 99.9 38.2 350 SER 83.6 100.0 49.0 351 ARG 164.7 78.8 64.3 352 GLY 29.8 85.7 67.6 353 ASP 0.0 0.0 82.5 354 ASP 78.1 70.7 63.1 355 TYR 164.0 90.6 49.6