Protein Data Bank File : 1a6q Title : HYDROLASE 27-FEB-98 1A6Q Number of Amino Acid Residues : 363 Amino Acid Sequence : 1 2 3 4 5 6 7 8 9 10 0 GLY ALA PHE LEU ASP LYS PRO LYS MET GLU 10 LYS HIS ASN ALA GLN GLY GLN GLY ASN GLY 20 LEU ARG TYR GLY LEU SER SER MET GLN GLY 30 TRP ARG VAL GLU MET GLU ASP ALA HIS THR 40 ALA VAL ILE GLY LEU PRO SER GLY LEU GLU 50 SER TRP SER PHE PHE ALA VAL TYR ASP GLY 60 HIS ALA GLY SER GLN VAL ALA LYS TYR CYS 70 CYS GLU HIS LEU LEU ASP HIS ILE THR ASN 80 ASN GLN ASP PHE LYS GLY SER ALA GLY ALA 90 PRO SER VAL GLU ASN VAL LYS ASN GLY ILE 100 ARG THR GLY PHE LEU GLU ILE ASP GLU HIS 110 MET ARG VAL MET SER GLU LYS LYS HIS GLY 120 ALA ASP ARG SER GLY SER THR ALA VAL GLY 130 VAL LEU ILE SER PRO GLN HIS THR TYR PHE 140 ILE ASN CYS GLY ASP SER ARG GLY LEU LEU 150 CYS ARG ASN ARG LYS VAL HIS PHE PHE THR 160 GLN ASP HIS LYS PRO SER ASN PRO LEU GLU 170 LYS GLU ARG ILE GLN ASN ALA GLY GLY SER 180 VAL MET ILE GLN ARG VAL ASN GLY SER LEU 190 ALA VAL SER ARG ALA LEU GLY ASP PHE ASP 200 TYR LYS CYS VAL HIS GLY LYS GLY PRO THR 210 GLU GLN LEU VAL SER PRO GLU PRO GLU VAL 220 HIS ASP ILE GLU ARG SER GLU GLU ASP ASP 230 GLN PHE ILE ILE LEU ALA CYS ASP GLY ILE 240 TRP ASP VAL MET GLY ASN GLU GLU LEU CYS 250 ASP PHE VAL ARG SER ARG LEU GLU VAL THR 260 ASP ASP LEU GLU LYS VAL CYS ASN GLU VAL 270 VAL ASP THR CYS LEU TYR LYS GLY SER ARG 280 ASP ASN MET SER VAL ILE LEU ILE CYS PHE 290 PRO ASN ALA PRO LYS VAL SER PRO GLU ALA 300 VAL LYS LYS GLU ALA GLU LEU ASP LYS TYR 310 LEU GLU CYS ARG VAL GLU GLU ILE ILE LYS 320 GLY VAL PRO ASP LEU VAL HIS VAL MET ARG 330 THR LEU ALA SER GLU ASN ILE PRO SER LEU 340 PRO PRO GLY GLY GLU LEU ALA SER LYS ARG 350 ASN VAL ILE GLU ALA VAL TYR ASN ARG LEU 360 ASN PRO TYR Main and Side Chain Dihedral Angles : Residue Type Phi Psi Omega Chi 1 Chi 2 Chi 3 Chi 4 1 GLY 0.0 -153.2 179.2 2 ALA -62.4 -144.4 -178.1 3 PHE 80.4 116.3 178.7 -73.4 -24.3 4 LEU -80.6 172.5 178.6 -87.0 5.7 5 ASP -77.3 -28.6 178.8 -28.1 82.4 6 LYS -144.0 147.2 -179.6 -74.8 -168.5 176.3 -168.8 7 PRO -75.5 146.9 176.5 34.7 -42.6 8 LYS -85.4 94.0 -179.4 -85.2 -171.7 -174.6 167.3 9 MET -77.2 7.6 -179.3 -48.6 -116.5 -157.6 10 GLU -64.3 127.4 179.9 -173.6 -176.0 2.6 11 LYS -96.3 134.9 178.0 -56.8 -61.3 -165.3 -54.6 12 HIS -113.2 114.3 -176.9 -64.8 75.9 13 ASN -113.4 167.2 176.0 -67.3 -63.0 14 ALA -163.7 157.3 -179.6 15 GLN -159.4 163.1 -178.5 68.5 -170.4 9.2 16 GLY -172.8 174.1 -176.8 17 GLN -150.0 149.1 179.6 -71.7 76.7 40.2 18 GLY 153.7 150.1 -180.0 19 ASN 57.9 32.3 179.6 -67.3 -18.3 20 GLY 81.4 -2.6 -178.3 21 LEU -102.1 160.5 177.1 -54.9 -177.5 22 ARG -143.2 144.1 179.0 -72.2 -171.1 76.1 -135.4 23 TYR -152.3 162.4 177.6 78.8 83.7 24 GLY -148.4 155.4 178.7 25 LEU -150.6 158.3 -178.9 62.4 84.5 26 SER -144.2 132.6 177.1 -178.7 27 SER -126.9 135.4 -178.6 50.2 28 MET -143.8 132.9 -179.4 -176.6 180.0 93.5 29 GLN -67.5 -33.3 179.7 -170.6 176.7 -47.8 30 GLY 65.6 -143.2 -179.1 31 TRP -74.6 -16.2 -179.0 -72.8 96.5 32 ARG -71.5 146.8 -178.9 -62.0 -56.1 -169.5 84.3 33 VAL -68.2 -34.5 179.1 159.1 34 GLU -120.5 163.5 177.3 -53.8 -70.8 -9.1 35 MET -111.2 117.4 -177.7 175.2 49.3 151.7 36 GLU -117.4 6.9 176.9 -63.6 -177.8 -26.6 37 ASP -88.4 158.5 177.0 -76.0 -8.4 38 ALA -151.9 175.2 -179.8 39 HIS -163.3 168.0 178.5 62.1 -96.0 40 THR -135.6 139.8 178.3 -54.8 41 ALA -147.2 110.4 -179.0 42 VAL -147.8 129.6 179.2 70.7 43 ILE -109.5 118.5 -179.0 -63.9 -170.2 44 GLY 95.9 102.4 -179.0 45 LEU -94.9 145.9 179.4 -50.0 -165.9 46 PRO -71.3 172.6 179.0 26.9 -41.4 47 SER 67.0 32.6 179.1 -72.3 48 GLY 91.0 24.7 -179.9 49 LEU -128.0 35.5 -179.4 -51.2 -178.6 50 GLU -60.6 -21.8 179.1 169.0 55.3 47.8 51 SER -85.2 -7.3 -179.8 -61.3 52 TRP -95.0 157.4 177.3 -102.2 -108.0 53 SER -136.9 161.5 179.4 -53.0 54 PHE -147.9 131.2 179.4 178.5 72.1 55 PHE -136.2 141.0 -179.3 -55.7 85.8 56 ALA -158.2 150.4 178.8 57 VAL -122.1 136.1 -179.4 165.9 58 TYR -120.8 124.8 178.4 -49.7 -87.2 59 ASP -107.1 97.0 -179.1 -177.4 -10.5 60 GLY -75.5 153.9 177.8 61 HIS -140.1 151.9 -177.4 48.0 -106.8 62 ALA 52.3 36.3 -179.2 63 GLY 129.4 168.0 -179.7 64 SER -111.4 -6.8 -179.5 57.3 65 GLN -53.5 -44.1 -179.3 -73.1 118.7 142.3 66 VAL -72.9 -45.5 179.5 168.1 67 ALA -56.1 -53.2 179.6 68 LYS -60.3 -38.5 179.7 -77.1 176.8 -172.9 171.1 69 TYR -67.5 -41.3 -179.1 -179.2 82.5 70 CYS -58.1 -45.0 -177.7 -84.4 71 CYS -65.9 -12.5 179.6 94.3 72 GLU -112.4 -10.9 -178.0 -54.2 170.4 -44.9 73 HIS -139.9 -3.0 -179.7 -62.6 102.4 74 LEU -60.6 -38.0 -177.6 179.5 63.9 75 LEU -62.3 -49.8 -178.5 -145.9 -144.7 76 ASP -66.2 -33.9 178.4 54.3 89.5 77 HIS -64.1 -32.1 178.9 -80.6 87.6 78 ILE -72.7 -55.4 -177.7 -72.0 174.4 79 THR -73.4 -23.6 -178.3 61.8 80 ASN -97.6 44.6 178.1 -90.5 -57.3 81 ASN -132.5 158.9 -177.3 69.9 72.6 82 GLN -60.9 -25.4 179.9 73.8 -169.8 162.0 83 ASP -75.4 -41.8 178.3 -58.4 -59.0 84 PHE -67.8 -45.6 -179.2 -174.3 -84.2 85 LYS -65.4 -59.2 179.9 -69.1 -168.6 172.8 -170.4 86 GLY 45.3 39.9 -178.2 87 SER -4.6 99.1 179.5 -67.9 88 ALA -162.5 -139.2 177.6 89 GLY -83.0 -116.3 178.2 90 ALA -86.0 153.1 -180.0 91 PRO -61.9 131.9 177.6 -25.9 42.5 92 SER -75.5 167.3 179.9 62.9 93 VAL -53.4 -44.7 179.6 167.0 94 GLU -63.1 -38.9 179.1 -63.5 82.1 16.3 95 ASN -61.2 -44.3 180.0 -70.8 150.5 96 VAL -65.5 -44.1 179.2 173.8 97 LYS -67.5 -46.1 177.8 -74.0 -176.2 153.2 -169.3 98 ASN -65.5 -40.5 179.6 -62.7 156.6 99 GLY -58.4 -39.8 179.1 100 ILE -71.5 -42.9 179.1 -65.0 165.5 101 ARG -60.1 -49.6 179.0 -149.9 -167.8 75.9 117.3 102 THR -63.0 -38.4 177.5 -61.7 103 GLY -59.1 -43.2 179.5 104 PHE -65.8 -50.3 -179.9 -88.0 72.6 105 LEU -62.9 -40.1 -178.8 -51.4 -152.7 106 GLU -71.4 -39.7 178.7 -65.8 -163.6 -27.5 107 ILE -69.7 -31.3 179.8 -164.5 -173.9 108 ASP -64.8 -55.0 179.3 -154.2 33.4 109 GLU -58.8 -41.2 178.9 -172.6 63.7 13.8 110 HIS -58.1 -45.3 178.5 179.2 0.4 111 MET -67.5 -37.2 179.6 -73.7 -175.3 -71.0 112 ARG -60.4 -43.2 179.1 -177.2 178.4 -134.9 154.5 113 VAL -69.4 -35.7 179.4 -43.0 114 MET -63.9 -43.2 -179.4 -69.9 176.4 130.2 115 SER -64.2 -45.3 179.5 -176.5 116 GLU -62.5 -44.4 -179.0 160.9 -80.0 -50.9 117 LYS -60.0 -52.9 -179.9 -157.6 160.3 46.5 -167.4 118 LYS -90.5 10.1 -179.7 -62.8 -175.9 -167.1 -176.4 119 HIS 55.2 47.6 -179.2 -57.2 105.9 120 GLY -54.6 134.9 -179.1 121 ALA -96.9 -14.1 -178.3 122 ASP -79.3 156.1 179.9 76.4 -87.4 123 ARG -130.3 43.0 -178.7 -118.6 89.7 -91.6 -167.5 124 SER -82.0 173.6 178.6 62.3 125 GLY -156.3 170.3 179.6 126 SER -157.4 151.3 176.7 -177.1 127 THR -91.2 174.3 176.5 66.8 128 ALA -157.2 130.6 175.4 129 VAL -140.3 140.7 178.5 67.4 130 GLY -170.5 -175.2 177.3 131 VAL -135.4 138.1 175.1 -87.2 132 LEU -110.1 114.5 -178.4 -137.2 -151.8 133 ILE -106.5 118.6 179.3 -61.2 171.2 134 SER -103.6 178.3 -179.8 67.7 135 PRO -64.5 -17.1 -178.1 -25.0 41.2 136 GLN -129.1 0.5 -179.9 -64.1 169.5 125.8 137 HIS -147.3 147.6 174.2 -64.0 105.3 138 THR -116.0 121.8 179.5 58.5 139 TYR -104.3 109.0 178.1 -60.7 -87.6 140 PHE -76.1 141.3 -179.2 -90.8 76.6 141 ILE -125.2 125.1 178.1 -58.1 167.4 142 ASN -138.1 134.8 179.3 -168.9 -108.3 143 CYS -150.6 87.3 178.1 -179.7 144 GLY 128.8 -153.8 -177.9 145 ASP -109.1 17.5 174.2 66.5 -5.6 146 SER -78.5 170.5 -179.4 -74.6 147 ARG -149.3 149.3 178.9 -171.8 -174.9 -46.1 153.8 148 GLY -132.8 149.1 177.6 149 LEU -141.6 153.4 178.8 69.2 71.0 150 LEU -114.6 122.5 176.9 -173.3 -115.3 151 CYS -96.5 124.2 -179.8 171.4 152 ARG -133.8 131.0 179.7 172.2 172.7 -58.4 -175.3 153 ASN 56.8 38.9 178.8 -156.8 98.7 154 ARG 68.2 17.7 -179.2 -52.9 165.2 57.9 123.6 155 LYS -134.4 163.8 178.5 -64.6 173.1 -57.8 178.8 156 VAL -82.2 97.2 -178.8 170.0 157 HIS -72.9 -32.6 179.9 -169.8 -99.4 158 PHE -158.7 152.2 174.6 166.2 -88.5 159 PHE -152.9 149.3 -179.3 73.7 88.4 160 THR -75.5 148.3 179.9 58.5 161 GLN -96.1 117.7 -179.5 -101.1 -69.5 106.4 162 ASP -61.6 137.5 178.7 -55.7 -9.5 163 HIS -88.7 96.2 179.3 -67.4 125.0 164 LYS -106.1 142.8 -179.5 -58.6 -57.7 -64.4 175.1 165 PRO -52.7 -40.2 179.5 -30.8 44.2 166 SER -74.2 -3.0 177.6 50.7 167 ASN -65.1 132.8 -179.1 -75.0 -0.5 168 PRO -32.4 -59.9 -178.8 -40.1 46.1 169 LEU -68.2 -36.2 180.0 -59.2 177.4 170 GLU -67.0 -45.0 179.7 -51.6 -56.1 -68.5 171 LYS -59.7 -45.0 179.9 -172.7 176.8 169.5 59.3 172 GLU -54.9 -53.2 -179.8 -139.2 171.1 -87.8 173 ARG -59.8 -52.2 -179.7 -168.1 -133.5 -49.1 135.9 174 ILE -51.7 -47.7 179.3 -68.0 169.6 175 GLN -65.6 -41.3 179.2 -75.6 168.2 -11.0 176 ASN -72.0 -17.8 178.6 -67.0 166.6 177 ALA -91.0 11.1 178.4 178 GLY 89.7 -2.4 -179.5 179 GLY -93.0 -168.8 179.3 180 SER -148.6 154.3 178.3 54.4 181 VAL -109.7 111.3 179.4 173.8 182 MET -102.5 104.0 -176.7 -64.6 171.5 -167.8 183 ILE 69.8 -95.2 179.3 -58.1 -53.7 184 GLN -123.4 8.6 -176.8 -107.7 69.0 85.5 185 ARG -124.3 139.0 177.5 -58.2 179.8 174.5 -119.8 186 VAL -60.6 114.3 179.4 -177.9 187 ASN 54.1 31.3 179.2 -60.4 -19.8 188 GLY 75.9 6.0 -178.0 189 SER -118.4 -57.4 -178.1 -40.7 190 LEU -86.8 125.7 -179.0 -120.8 53.2 191 ALA -88.6 -0.1 178.1 192 VAL -123.2 144.7 179.6 -64.4 193 SER -95.6 -13.8 179.4 54.6 194 ARG -134.8 141.1 -179.9 -61.9 -160.7 -167.9 -172.0 195 ALA 178.6 164.5 176.7 196 LEU -96.5 154.5 -178.4 -64.2 131.2 197 GLY 86.7 -152.5 -178.0 198 ASP 53.1 44.4 -177.7 -62.6 -37.9 199 PHE -60.0 -16.9 176.8 -61.0 -56.5 200 ASP -73.4 -20.3 179.8 -76.6 -14.0 201 TYR -95.4 4.5 -179.4 -76.0 84.4 202 LYS -123.3 42.1 -179.5 -63.9 178.4 -176.8 159.4 203 CYS -119.7 14.6 179.9 -62.1 204 VAL -68.9 115.2 -179.4 177.7 205 HIS -76.0 137.7 -179.7 -57.6 -47.8 206 GLY 93.8 4.3 179.8 207 LYS -127.8 144.6 179.2 -76.5 -52.8 -176.6 -169.6 208 GLY -72.0 176.0 -179.8 209 PRO -59.3 -34.5 -179.1 -27.3 42.6 210 THR -97.4 18.3 179.7 61.8 211 GLU -127.5 16.6 -179.8 -51.9 175.3 -39.6 212 GLN -82.6 -179.5 178.4 -55.6 -67.6 -41.3 213 LEU -60.9 -45.8 178.4 -61.1 173.5 214 VAL -113.5 133.2 -178.5 170.6 215 SER -108.9 137.7 179.7 176.3 216 PRO -89.5 3.1 -177.6 40.1 -43.4 217 GLU -76.1 126.1 -180.0 -160.8 179.1 11.1 218 PRO -90.4 159.8 176.7 41.9 -44.1 219 GLU -110.5 128.2 -176.4 -160.5 170.3 -39.5 220 VAL -124.2 134.7 -179.4 174.3 221 HIS -131.7 124.3 179.9 -68.5 104.6 222 ASP -87.8 123.0 178.0 163.2 30.3 223 ILE -124.2 119.7 179.4 -58.4 176.4 224 GLU -69.1 133.5 -179.8 -66.4 -177.8 17.3 225 ARG -68.8 156.7 179.9 -67.9 -179.1 64.1 -176.1 226 SER -138.7 100.7 -178.7 152.4 227 GLU -53.7 -43.3 -178.8 147.6 79.7 26.9 228 GLU -70.8 -37.9 -177.1 -70.1 -41.8 -60.4 229 ASP -103.8 -22.3 179.7 -70.1 -34.2 230 ASP -66.5 125.3 -178.7 -80.0 -21.4 231 GLN -106.4 -64.7 178.8 -60.8 -158.4 -72.7 232 PHE -157.0 162.1 -179.7 53.9 85.2 233 ILE -121.6 143.9 178.7 -67.7 177.2 234 ILE -128.2 124.0 176.7 -63.6 179.0 235 LEU -119.4 129.0 179.8 -58.1 177.1 236 ALA -154.3 155.0 178.2 237 CYS -81.9 163.0 179.0 65.6 238 ASP -54.7 -11.9 178.5 61.8 0.4 239 GLY -65.3 -26.7 178.2 240 ILE -87.0 -58.6 -178.2 -66.3 -61.9 241 TRP -58.1 -28.6 179.6 -56.3 120.3 242 ASP -59.0 -26.4 -175.4 -81.9 -13.8 243 VAL -119.5 -5.4 178.8 81.3 244 MET -138.9 129.8 -179.4 -76.2 -172.1 78.6 245 GLY -76.7 173.4 -179.6 246 ASN -57.3 -55.9 -179.1 -73.3 -11.7 247 GLU -72.3 -31.9 177.6 -160.6 57.2 84.8 248 GLU -62.7 -50.2 -178.1 -82.4 -172.7 -68.6 249 LEU -64.8 -46.7 179.3 -171.8 54.6 250 CYS -54.7 -52.3 178.9 -168.4 251 ASP -59.4 -40.0 -179.7 -77.7 -5.0 252 PHE -64.0 -50.3 179.2 179.1 57.1 253 VAL -60.0 -40.2 177.8 160.9 254 ARG -57.3 -51.2 -179.5 -173.4 176.8 -42.0 128.8 255 SER -56.3 -37.2 -179.6 79.0 256 ARG -75.5 -31.5 178.9 -53.6 -59.9 82.8 -164.0 257 LEU -71.6 -33.3 178.4 -75.6 172.5 258 GLU -67.5 -13.1 -179.4 -67.9 172.5 -10.2 259 VAL -105.8 -31.1 -179.9 164.9 260 THR -146.4 156.8 177.5 -40.5 261 ASP -112.4 6.5 179.9 63.3 -4.2 262 ASP -83.1 99.0 -178.2 -177.7 -14.8 263 LEU -65.7 -26.8 177.9 -53.0 -172.3 264 GLU -69.8 -36.5 179.4 -71.4 -172.5 -13.3 265 LYS -69.0 -39.9 179.4 177.4 -170.0 175.7 -162.2 266 VAL -62.3 -40.7 177.7 172.7 267 CYS -65.6 -42.9 178.4 -69.0 268 ASN -61.8 -37.7 178.9 -69.8 -14.8 269 GLU -66.3 -36.3 178.6 -74.3 -176.7 -69.8 270 VAL -67.2 -45.4 -179.6 170.7 271 VAL -61.6 -48.6 179.1 167.3 272 ASP -66.6 -35.8 178.5 -75.4 -19.0 273 THR -63.7 -41.8 179.5 -67.4 274 CYS -69.9 -31.5 176.7 -67.6 275 LEU -69.4 -45.0 -179.8 -176.3 -80.5 276 TYR -68.4 -21.9 178.0 -62.3 -28.0 277 LYS -83.4 -1.7 178.0 -78.0 168.5 174.7 -67.4 278 GLY 108.3 5.7 -179.6 279 SER -70.2 129.3 -177.9 -173.9 280 ARG -118.6 33.2 -179.5 -65.0 176.3 68.4 96.6 281 ASP -121.0 169.4 175.8 -170.0 12.1 282 ASN -64.9 145.7 179.8 -66.7 151.9 283 MET -130.9 131.9 -179.7 -71.7 170.9 -81.2 284 SER -140.4 134.1 178.9 -64.4 285 VAL -138.1 142.7 175.4 -147.7 286 ILE -127.9 124.6 -179.5 -59.4 -169.0 287 LEU -114.4 116.2 179.2 -150.7 -144.3 288 ILE -115.3 115.5 -179.0 -56.2 107.1 289 CYS -99.6 142.4 178.9 -70.4 290 PHE -101.7 167.9 -179.8 -73.3 -78.5 291 PRO -42.1 -40.6 -178.4 -35.9 44.5 292 ASN -99.9 30.3 176.9 -66.5 28.1 293 ALA -66.6 153.8 179.7 294 PRO -58.7 148.9 -177.6 22.9 -37.4 295 LYS -103.8 161.1 178.8 -50.7 -78.8 140.1 48.2 296 VAL -64.7 132.9 -178.5 176.1 297 SER -114.8 124.5 179.5 156.4 298 PRO -53.6 -41.6 -179.5 14.1 -32.8 299 GLU -69.3 -35.9 179.9 -150.1 178.1 -46.8 300 ALA -66.1 -42.6 177.7 301 VAL -62.8 -40.2 178.6 178.1 302 LYS -61.8 -53.0 179.1 -84.1 -159.9 179.0 -178.0 303 LYS -56.4 -33.7 -180.0 -64.7 178.0 171.9 172.1 304 GLU -68.5 -44.5 179.4 -173.5 72.7 -4.2 305 ALA -63.3 -40.8 178.7 306 GLU -63.0 -44.0 -179.8 -73.0 154.9 26.0 307 LEU -66.0 -41.4 179.3 174.0 65.7 308 ASP -63.9 -41.0 -179.9 -73.9 -6.3 309 LYS -66.6 -42.2 178.8 -179.1 55.3 173.2 -170.9 310 TYR -61.6 -43.5 179.0 178.9 -81.2 311 LEU -65.4 -36.9 -179.9 -72.2 177.6 312 GLU -65.5 -36.1 179.1 -56.2 177.9 -43.8 313 CYS -70.7 -41.0 179.0 -63.9 314 ARG -57.6 -47.5 180.0 -74.0 -78.7 60.4 -132.6 315 VAL -58.6 -45.4 179.2 169.5 316 GLU -55.4 -47.4 -179.4 -71.8 -166.8 75.4 317 GLU -68.2 -43.6 -179.3 -71.4 -82.8 -80.8 318 ILE -66.6 -47.4 179.1 -68.8 176.0 319 ILE -59.9 -11.1 178.1 -139.6 169.5 320 LYS 89.9 -110.5 124.2 -51.6 -96.1 73.9 -75.1 321 GLY -42.8 8.3 -179.4 322 VAL 64.8 95.1 180.0 159.4 323 PRO -70.0 145.4 178.7 34.5 -46.0 324 ASP -67.0 161.3 -178.9 48.2 -46.0 325 LEU -53.6 -38.8 178.1 -179.0 53.6 326 VAL -54.4 -39.5 -179.3 -176.9 327 HIS -80.7 -29.2 179.4 -76.2 65.4 328 VAL -69.9 -38.9 178.8 168.9 329 MET -64.1 -39.3 179.5 -73.5 -59.5 -61.7 330 ARG -60.3 -47.6 179.3 -164.8 158.3 -64.4 156.3 331 THR -61.7 -59.7 -179.6 -50.2 332 LEU -44.1 -42.1 -179.0 -67.5 170.6 333 ALA -67.6 -36.0 -179.2 334 SER -73.1 -14.9 179.6 65.2 335 GLU -79.2 -13.3 179.4 -66.0 -178.2 7.9 336 ASN 46.2 60.0 179.9 -58.9 -50.4 337 ILE -63.8 131.9 -179.9 -65.2 165.1 338 PRO -80.8 159.2 178.1 39.2 -43.8 339 SER 67.2 31.9 177.9 -47.4 340 LEU -83.2 151.9 -179.6 -67.8 169.0 341 PRO -49.0 129.0 179.7 -32.6 44.3 342 PRO -60.7 137.3 -179.6 27.9 -42.1 343 GLY 79.9 -54.8 179.7 344 GLY -70.0 -33.8 179.5 345 GLU 51.4 -148.2 -179.4 -70.2 -55.2 -57.2 346 LEU -62.5 -33.9 179.3 -109.6 -169.4 347 ALA -58.1 -35.7 178.4 348 SER -73.7 -6.8 179.0 66.0 349 LYS -113.2 5.0 -179.6 -57.4 -51.4 -64.4 179.2 350 ARG -61.0 -36.6 179.2 -169.7 168.7 -174.9 -57.8 351 ASN -68.3 -30.4 177.2 -73.1 -23.7 352 VAL -69.9 -48.3 -179.7 173.2 353 ILE -60.7 -50.1 179.7 -66.9 163.2 354 GLU -63.4 -34.6 179.5 -179.6 176.3 42.9 355 ALA -66.3 -40.3 178.3 356 VAL -67.4 -48.5 179.9 -175.4 357 TYR -53.5 -44.9 179.9 179.6 -84.6 358 ASN -61.1 -38.9 178.3 -83.2 -1.6 359 ARG -66.1 -42.1 -179.8 -67.3 -159.7 -77.4 -81.0 360 LEU -75.6 -31.0 -179.5 -60.8 173.9 361 ASN -134.9 63.4 -179.3 -170.2 20.4 362 PRO -57.9 -25.5 -179.4 28.8 -41.6 363 TYR -98.3 159.6 0.0 -46.0 -54.5 Alpha Carbon Cartesian Coordinates : Residue Type X Y Z 1 GLY -31.514 38.435 51.826 2 ALA -31.483 38.058 48.029 3 PHE -34.685 37.512 45.986 4 LEU -35.699 39.917 43.261 5 ASP -39.196 41.445 43.211 6 LYS -39.696 39.394 40.044 7 PRO -37.452 36.604 38.697 8 LYS -34.999 37.180 35.853 9 MET -36.454 34.602 33.489 10 GLU -33.819 35.277 30.827 11 LYS -32.473 31.979 29.494 12 HIS -28.858 31.579 28.522 13 ASN -28.674 28.635 26.142 14 ALA -26.142 26.627 24.213 15 GLN -26.153 23.499 22.091 16 GLY -23.855 21.362 20.051 17 GLN -23.314 18.049 18.349 18 GLY -20.275 15.807 17.920 19 ASN -18.812 12.401 18.822 20 GLY -22.263 10.890 18.382 21 LEU -23.613 13.305 20.994 22 ARG -26.057 16.227 20.878 23 TYR -26.677 18.628 23.710 24 GLY -28.525 21.713 24.849 25 LEU -28.337 23.672 28.079 26 SER -30.166 26.425 29.887 27 SER -29.099 28.724 32.692 28 MET -31.531 31.135 34.330 29 GLN -31.023 33.443 37.286 30 GLY -34.600 33.068 38.565 31 TRP -35.536 34.773 41.863 32 ARG -31.994 35.215 43.118 33 VAL -30.372 38.643 43.077 34 GLU -27.116 37.288 41.612 35 MET -26.338 34.435 39.237 36 GLU -23.806 32.064 40.741 37 ASP -24.141 28.943 38.594 38 ALA -21.714 28.175 35.763 39 HIS -21.092 25.248 33.391 40 THR -18.787 23.640 30.890 41 ALA -20.000 21.905 27.714 42 VAL -17.353 20.630 25.369 43 ILE -17.238 17.933 22.719 44 GLY -13.728 16.863 21.786 45 LEU -10.976 17.282 24.357 46 PRO -7.468 18.534 23.608 47 SER -4.202 16.552 24.052 48 GLY -5.409 13.444 22.254 49 LEU -8.958 13.194 23.623 50 GLU -10.871 14.560 20.650 51 SER -13.147 11.531 21.010 52 TRP -13.883 12.580 24.593 53 SER -16.477 15.213 25.665 54 PHE -16.978 16.972 28.998 55 PHE -20.025 18.565 30.577 56 ALA -20.362 19.950 34.157 57 VAL -22.615 22.262 36.194 58 TYR -21.204 24.418 38.975 59 ASP -23.447 25.841 41.674 60 GLY -21.464 28.660 43.260 61 HIS -22.269 30.022 46.710 62 ALA -21.230 33.189 48.545 63 GLY -20.061 34.362 45.119 64 SER -19.440 33.146 41.539 65 GLN -15.632 33.378 41.448 66 VAL -14.980 29.740 42.316 67 ALA -17.770 28.473 40.054 68 LYS -16.493 30.588 37.145 69 TYR -12.862 29.634 37.588 70 CYS -13.978 26.011 37.738 71 CYS -15.983 26.196 34.531 72 GLU -12.932 27.308 32.555 73 HIS -10.235 25.188 34.134 74 LEU -11.535 22.222 36.001 75 LEU -11.038 20.214 32.802 76 ASP -7.434 21.016 32.124 77 HIS -6.612 20.446 35.759 78 ILE -8.174 17.004 35.371 79 THR -6.534 15.976 32.065 80 ASN -3.214 17.711 32.698 81 ASN -1.833 15.839 35.688 82 GLN 0.451 12.824 35.953 83 ASP -2.336 10.566 37.276 84 PHE -4.747 11.138 34.421 85 LYS -1.894 10.890 32.000 86 GLY -0.102 8.002 33.675 87 SER 2.003 7.930 30.507 88 ALA 1.080 4.772 28.596 89 GLY -1.462 4.270 25.827 90 ALA -4.959 5.531 26.596 91 PRO -5.833 6.332 30.245 92 SER -7.057 3.335 32.244 93 VAL -10.223 3.653 34.341 94 GLU -7.983 4.199 37.380 95 ASN -5.943 6.890 35.541 96 VAL -9.172 8.651 34.800 97 LYS -10.492 8.309 38.380 98 ASN -7.186 9.307 39.995 99 GLY -6.760 12.024 37.385 100 ILE -10.125 13.525 38.354 101 ARG -9.466 13.308 42.104 102 THR -6.096 15.052 41.624 103 GLY -7.670 17.592 39.283 104 PHE -10.106 18.563 42.029 105 LEU -7.520 18.732 44.783 106 GLU -5.037 20.603 42.603 107 ILE -7.392 23.241 41.269 108 ASP -8.658 23.793 44.832 109 GLU -5.184 24.378 46.249 110 HIS -4.367 26.365 43.110 111 MET -7.309 28.742 43.673 112 ARG -6.311 28.938 47.334 113 VAL -2.787 30.143 46.506 114 MET -4.127 32.665 44.002 115 SER -6.475 34.030 46.637 116 GLU -3.802 34.210 49.340 117 LYS -1.386 35.750 46.811 118 LYS -3.737 38.443 45.483 119 HIS -5.470 38.973 48.851 120 GLY -8.725 37.681 47.417 121 ALA -11.663 39.079 49.279 122 ASP -14.260 36.579 48.207 123 ARG -15.182 33.632 50.313 124 SER -17.155 31.758 47.659 125 GLY -17.330 28.053 47.013 126 SER -18.902 25.827 44.389 127 THR -20.236 22.369 43.752 128 ALA -19.361 20.508 40.571 129 VAL -21.189 17.669 38.836 130 GLY -20.398 16.423 35.350 131 VAL -19.612 13.577 32.971 132 LEU -16.338 12.785 31.227 133 ILE -17.479 10.770 28.185 134 SER -14.970 8.553 26.409 135 PRO -15.759 6.367 23.454 136 GLN -16.631 3.533 25.863 137 HIS -17.375 5.054 29.294 138 THR -19.253 7.859 30.900 139 TYR -17.495 8.766 34.118 140 PHE -19.893 10.607 36.375 141 ILE -18.243 13.222 38.535 142 ASN -19.702 14.601 41.772 143 CYS -18.657 17.004 44.455 144 GLY -21.528 18.642 46.321 145 ASP -25.275 18.729 45.985 146 SER -25.684 19.331 42.289 147 ARG -26.834 16.059 40.631 148 GLY -26.530 14.058 37.449 149 LEU -28.366 11.022 36.146 150 LEU -28.091 8.639 33.207 151 CYS -31.339 7.477 31.607 152 ARG -30.928 4.079 29.969 153 ASN -33.767 2.038 28.517 154 ARG -36.321 4.635 29.653 155 LYS -35.184 4.273 33.270 156 VAL -32.795 6.005 35.674 157 HIS -29.768 3.765 35.265 158 PHE -27.577 5.819 37.577 159 PHE -27.648 9.060 39.542 160 THR -25.114 10.839 41.713 161 GLN -25.447 10.818 45.501 162 ASP -25.599 14.359 46.919 163 HIS -23.004 15.264 49.537 164 LYS -25.064 16.532 52.490 165 PRO -23.415 17.300 55.888 166 SER -25.672 14.908 57.825 167 ASN -24.627 11.998 55.593 168 PRO -22.908 9.549 58.019 169 LEU -19.418 9.778 56.601 170 GLU -19.547 13.542 55.939 171 LYS -20.771 14.076 59.482 172 GLU -17.972 11.802 60.666 173 ARG -15.349 13.859 58.901 174 ILE -16.893 17.152 59.969 175 GLN -16.925 16.083 63.634 176 ASN -13.406 14.745 63.453 177 ALA -12.327 18.007 61.833 178 GLY -13.558 19.723 64.976 179 GLY -16.905 20.794 63.558 180 SER -20.552 19.905 64.089 181 VAL -23.557 19.282 61.884 182 MET -26.474 21.370 63.147 183 ILE -29.677 20.021 61.578 184 GLN -28.409 19.989 57.933 185 ARG -25.511 22.468 58.132 186 VAL -21.798 22.429 58.905 187 ASN -21.725 24.488 62.094 188 GLY -25.195 25.771 61.297 189 SER -24.038 27.504 58.117 190 LEU -22.978 25.369 55.125 191 ALA -25.533 23.028 53.559 192 VAL -22.961 21.028 51.522 193 SER -20.155 18.891 52.879 194 ARG -18.102 18.986 49.685 195 ALA -17.229 21.783 47.312 196 LEU -14.261 23.603 45.917 197 GLY -13.486 26.933 47.545 198 ASP -14.862 27.625 51.041 199 PHE -11.272 27.944 52.288 200 ASP -12.307 29.083 55.778 201 TYR -13.676 25.591 56.265 202 LYS -10.383 24.126 55.143 203 CYS -8.068 25.468 57.850 204 VAL -8.218 22.613 60.367 205 HIS -4.641 22.090 61.484 206 GLY -3.754 18.441 61.773 207 LYS -6.081 17.347 58.963 208 GLY -5.446 16.556 55.327 209 PRO -7.079 18.328 52.345 210 THR -9.769 15.679 52.342 211 GLU -10.272 15.689 56.128 212 GLN -11.326 19.324 56.593 213 LEU -14.833 20.551 57.479 214 VAL -15.622 20.869 53.734 215 SER -13.989 18.456 51.286 216 PRO -12.887 19.089 47.670 217 GLU -12.837 15.329 47.055 218 PRO -15.117 14.079 44.207 219 GLU -16.982 10.797 43.788 220 VAL -16.389 9.188 40.395 221 HIS -18.282 6.343 38.810 222 ASP -17.324 4.568 35.668 223 ILE -20.342 3.429 33.591 224 GLU -19.649 1.435 30.416 225 ARG -21.516 2.908 27.520 226 SER -24.294 1.073 25.726 227 GLU -24.884 2.337 22.176 228 GLU -28.196 0.544 22.062 229 ASP -29.562 1.542 25.456 230 ASP -27.998 4.864 26.478 231 GLN -30.578 7.600 25.961 232 PHE -29.633 10.820 27.757 233 ILE -27.784 12.388 30.659 234 ILE -29.075 15.251 32.802 235 LEU -26.759 17.445 34.875 236 ALA -28.440 20.138 36.994 237 CYS -27.917 22.217 40.139 238 ASP -30.185 21.722 43.190 239 GLY -32.341 24.577 41.857 240 ILE -33.743 21.904 39.549 241 TRP -33.507 18.910 41.871 242 ASP -35.056 20.760 44.821 243 VAL -38.393 20.595 43.119 244 MET -38.329 17.565 40.763 245 GLY -37.208 14.052 41.528 246 ASN -34.981 11.768 39.455 247 GLU -37.651 9.687 37.754 248 GLU -40.046 12.659 37.459 249 LEU -37.471 14.739 35.628 250 CYS -36.334 11.757 33.594 251 ASP -39.975 10.996 32.658 252 PHE -40.622 14.675 31.958 253 VAL -37.644 15.094 29.651 254 ARG -38.640 11.932 27.767 255 SER -42.107 13.410 27.173 256 ARG -40.573 16.664 25.908 257 LEU -38.146 14.789 23.693 258 GLU -41.029 12.879 22.121 259 VAL -42.300 16.312 21.162 260 THR -39.113 18.193 20.135 261 ASP -35.480 17.638 19.228 262 ASP -34.559 21.213 20.091 263 LEU -32.479 20.447 23.158 264 GLU -32.254 24.124 24.200 265 LYS -36.056 24.277 24.258 266 VAL -36.275 21.085 26.314 267 CYS -33.882 22.619 28.861 268 ASN -35.864 25.905 28.972 269 GLU -38.983 23.864 29.592 270 VAL -37.317 22.087 32.517 271 VAL -36.164 25.408 34.017 272 ASP -39.561 27.137 33.703 273 THR -41.368 24.087 35.027 274 CYS -39.089 24.135 38.099 275 LEU -39.552 27.891 38.550 276 TYR -43.325 27.331 38.314 277 LYS -43.030 24.489 40.797 278 GLY -41.583 27.053 43.175 279 SER -37.820 26.952 42.796 280 ARG -36.384 30.289 43.870 281 ASP -32.787 29.481 43.148 282 ASN -30.479 29.896 40.153 283 MET -31.180 27.011 37.713 284 SER -28.866 25.276 35.226 285 VAL -29.432 22.099 33.171 286 ILE -27.356 20.269 30.571 287 LEU -29.166 17.610 28.514 288 ILE -26.808 15.336 26.575 289 CYS -28.587 12.920 24.253 290 PHE -27.101 9.710 22.810 291 PRO -28.007 8.055 19.461 292 ASN -30.941 6.156 20.977 293 ALA -32.411 9.072 22.891 294 PRO -36.158 9.151 22.432 295 LYS -37.298 10.546 19.035 296 VAL -40.025 13.014 18.072 297 SER -43.363 11.244 17.786 298 PRO -46.115 12.458 15.461 299 GLU -48.787 11.224 17.861 300 ALA -47.011 12.882 20.803 301 VAL -46.881 16.189 18.960 302 LYS -50.622 15.743 18.187 303 LYS -51.562 15.049 21.782 304 GLU -49.545 18.135 22.749 305 ALA -51.411 20.339 20.265 306 GLU -54.713 18.881 21.490 307 LEU -53.793 19.576 25.109 308 ASP -52.692 23.114 24.366 309 LYS -55.950 23.826 22.508 310 TYR -57.923 22.231 25.318 311 LEU -56.111 24.345 27.911 312 GLU -56.807 27.494 25.871 313 CYS -60.557 26.781 25.802 314 ARG -60.650 26.114 29.518 315 VAL -59.034 29.515 30.115 316 GLU -61.534 31.178 27.796 317 GLU -64.455 29.687 29.705 318 ILE -62.917 30.249 33.156 319 ILE -61.778 33.833 32.580 320 LYS -65.525 34.079 31.821 321 GLY -64.868 39.919 37.288 322 VAL -61.996 38.222 35.433 323 PRO -59.760 36.271 37.870 324 ASP -56.031 36.795 37.995 325 LEU -53.744 34.092 36.498 326 VAL -53.001 32.768 39.970 327 HIS -56.677 31.940 40.255 328 VAL -57.044 30.553 36.751 329 MET -54.203 28.166 37.541 330 ARG -56.040 27.311 40.785 331 THR -59.225 26.444 38.916 332 LEU -57.370 24.454 36.251 333 ALA -55.689 22.431 38.967 334 SER -58.940 21.527 40.730 335 GLU -60.230 20.222 37.423 336 ASN -57.630 17.479 37.566 337 ILE -57.053 17.587 33.800 338 PRO -55.851 14.252 32.312 339 SER -52.801 13.791 30.152 340 LEU -50.605 16.534 31.599 341 PRO -46.854 16.023 31.055 342 PRO -45.562 13.370 33.477 343 GLY -43.467 14.939 36.220 344 GLY -43.935 18.446 34.841 345 GLU -47.701 18.359 35.415 346 LEU -49.679 21.658 35.233 347 ALA -46.566 23.729 36.005 348 SER -45.054 22.446 32.739 349 LYS -48.145 23.832 30.941 350 ARG -48.109 27.260 32.643 351 ASN -46.553 29.125 29.714 352 VAL -49.339 27.874 27.390 353 ILE -51.962 28.909 29.965 354 GLU -50.351 32.252 30.639 355 ALA -49.984 33.033 26.922 356 VAL -53.732 32.513 26.353 357 TYR -54.585 34.428 29.528 358 ASN -52.418 37.290 28.253 359 ARG -54.232 37.488 24.907 360 LEU -57.610 37.537 26.729 361 ASN -56.640 39.929 29.565 362 PRO -53.775 42.012 28.107 363 TYR -54.154 44.782 30.714 Richards-Kundrot Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 S S S S S/S S S S S S 10 S S S S S S C T T T 20 T/S S S S S/S S S S S C 30 C C S S S S S C S S 40 S S S S T T T T T T 50 T T/S S S S S/S S S S S/T 60 T T T H H H H H H H 70 H H H/H H H H H H H H 80 3/H H H H H H C C C C 90 C H H H H H H H H H 100 H H H H H H H H H H 110 H H H H H H H H H/S S 120 S S S S S S/S S S S S 130 S S S S/T T T T/S S S S 140 S S S S S S S S S S 150 S/T T T T C C S S S S 160 S S S S S C H H H H 170 H H H H H H H H/S S S 180 S/T T T T T T T T S S 190 S S S S S S S H H H 200 H H 3/S S S S C T T T 210 T C S S S S/S S S S S 220 S S S S S S/T T T T/S S 230 S S/S S S S S S/H H H H 240 H H 3 3 H H H H H H 250 H H H H H H H H H H 260 C H H H H H H H H H 270 H H H H H H H H C C 280 S S S S S S S S S S 290 S C S S S S S/H H H H 300 H H H H H H H H H H 310 H H H H H H H H H H/X 320 X/S S S S/H H H H H H H 330 H H H H H H/S S S S C 340 T T T T H H H H H H/H 350 H H H H H H H H H H 360 H/S S/S S Kabsch-Sander Secondary Structure Assignment : 1 2 3 4 5 6 7 8 9 10 0 S S E E E 10 E E E E E E E E T T 20 E E E E E E E E E E 30 T t S S e E E E E 40 E E E E E T T T E E 50 E E E E E E E E E E 60 E S h H H H H H H 70 H H H H H H H H H h 80 h H H H H h S S S S 90 h H H H H H H H H 100 H H H H H H H H H H 110 H H H H H H H h T t 120 e E E e E E E 130 E E E e S e E E E E 140 E E E S S E E E E 150 E E e T E E E E E e 160 t T T h H H H 170 H H H H H H h T t e 180 E E T T E E e T T B 190 S S B E E e G G 200 G g t T T t g G G 210 G g S S B E E 220 E E E E e t T T e E 230 E E E E E E h H H H 240 H h T t h H H H H H 250 H H H H H H H h T t 260 h H H H H H H H H 270 H H H H H H h T t 280 S E E E E E E E e 290 T T t h H H H 300 H H H H H H H H H H 310 H H H H H H H H h 320 h H H H H H H 330 H H H H h T t S S 340 t T T g G G G G h H 350 H H H H H H H H H H 360 h Buried Surface Area Percentages : Residue Type Buried Area % Buried % Polar Cover 1 GLY 0.0 0.0 95.3 2 ALA 40.9 56.3 59.4 3 PHE 85.6 51.3 71.3 4 LEU 116.4 78.8 62.5 5 ASP 0.0 0.0 80.3 6 LYS 10.2 5.9 78.2 7 PRO 113.5 91.1 32.3 8 LYS 62.5 36.0 77.8 9 MET 90.3 56.6 61.8 10 GLU 27.6 19.9 79.5 11 LYS 148.3 85.5 66.8 12 HIS 52.6 35.1 84.5 13 ASN 95.0 78.6 68.3 14 ALA 38.0 52.4 66.2 15 GLN 70.8 47.7 75.7 16 GLY 19.2 55.3 64.1 17 GLN 73.5 49.5 71.6 18 GLY 10.6 30.6 67.4 19 ASN 83.2 68.9 70.7 20 GLY 0.6 1.7 73.3 21 LEU 147.3 99.6 44.4 22 ARG 120.8 57.8 62.0 23 TYR 159.9 88.3 41.3 24 GLY 34.8 100.0 44.8 25 LEU 144.5 97.8 40.0 26 SER 83.6 100.0 51.1 27 SER 73.6 88.1 58.2 28 MET 159.4 100.0 44.8 29 GLN 131.2 88.3 53.6 30 GLY 34.8 100.0 51.8 31 TRP 154.4 75.3 57.6 32 ARG 120.1 57.5 71.8 33 VAL 64.6 54.4 63.3 34 GLU 30.2 21.8 77.2 35 MET 121.4 76.1 66.7 36 GLU 105.2 75.9 64.9 37 ASP 110.1 99.6 54.1 38 ALA 61.4 84.6 52.4 39 HIS 104.4 69.5 47.9 40 THR 85.9 80.3 52.4 41 ALA 67.9 93.6 40.7 42 VAL 70.8 59.6 58.8 43 ILE 129.9 90.5 52.6 44 GLY 34.7 99.7 72.2 45 LEU 147.5 99.8 31.1 46 PRO 28.4 22.8 79.3 47 SER 25.7 30.8 79.1 48 GLY 0.0 0.0 81.4 49 LEU 134.1 90.7 41.4 50 GLU 22.1 15.9 87.2 51 SER 31.6 37.8 64.0 52 TRP 179.8 87.7 37.2 53 SER 83.1 99.4 40.8 54 PHE 165.9 99.4 30.7 55 PHE 166.8 100.0 25.2 56 ALA 71.2 98.1 40.8 57 VAL 118.8 100.0 42.6 58 TYR 180.7 99.8 43.9 59 ASP 92.8 84.0 74.4 60 GLY 34.8 100.0 68.0 61 HIS 107.1 71.3 62.8 62 ALA 17.8 24.6 75.1 63 GLY 20.7 59.5 75.8 64 SER 64.7 77.4 63.5 65 GLN 61.0 41.0 74.1 66 VAL 109.2 91.9 48.2 67 ALA 72.5 99.8 51.9 68 LYS 53.3 30.7 75.2 69 TYR 138.6 76.6 50.0 70 CYS 99.2 100.0 33.3 71 CYS 79.6 80.2 59.7 72 GLU 42.4 30.6 76.3 73 HIS 84.7 56.4 70.4 74 LEU 146.2 98.9 30.3 75 LEU 124.7 84.4 33.2 76 ASP 59.6 54.0 68.9 77 HIS 121.8 81.1 56.2 78 ILE 143.5 100.0 32.2 79 THR 98.1 91.8 38.0 80 ASN 59.1 48.9 75.6 81 ASN 110.5 91.4 64.8 82 GLN 5.9 4.0 86.6 83 ASP 61.6 55.7 68.2 84 PHE 162.3 97.3 38.7 85 LYS 77.6 44.7 78.4 86 GLY 15.5 44.6 81.8 87 SER 0.8 1.0 82.5 88 ALA 15.2 20.9 88.3 89 GLY 0.0 0.0 81.0 90 ALA 14.9 20.5 71.5 91 PRO 111.5 89.6 48.3 92 SER 33.8 40.4 83.9 93 VAL 78.6 66.2 62.9 94 GLU 29.9 21.6 76.8 95 ASN 89.1 73.7 67.6 96 VAL 118.6 99.8 35.7 97 LYS 104.3 60.2 59.1 98 ASN 47.6 39.4 67.8 99 GLY 34.8 100.0 59.8 100 ILE 143.5 100.0 24.8 101 ARG 108.7 52.0 66.0 102 THR 80.6 75.4 68.9 103 GLY 34.8 100.0 60.2 104 PHE 166.8 100.0 29.6 105 LEU 119.9 81.1 50.6 106 GLU 60.0 43.3 64.6 107 ILE 143.5 100.0 33.2 108 ASP 103.9 94.1 41.2 109 GLU 42.4 30.6 71.0 110 HIS 93.5 62.2 59.1 111 MET 147.1 92.3 37.3 112 ARG 143.6 68.8 56.4 113 VAL 62.6 52.7 71.6 114 MET 99.0 62.1 63.7 115 SER 54.8 65.6 71.5 116 GLU 22.7 16.3 78.7 117 LYS 70.9 40.9 70.5 118 LYS 35.0 20.2 78.6 119 HIS 7.9 5.3 92.5 120 GLY 17.4 50.1 77.8 121 ALA 1.6 2.2 88.9 122 ASP 71.9 65.0 72.3 123 ARG 80.7 38.6 88.6 124 SER 83.6 100.0 66.9 125 GLY 34.8 100.0 56.3 126 SER 83.6 100.0 46.7 127 THR 105.1 98.3 62.8 128 ALA 71.7 98.7 42.5 129 VAL 118.8 100.0 54.0 130 GLY 34.4 98.7 40.7 131 VAL 118.8 100.0 29.2 132 LEU 147.8 100.0 27.6 133 ILE 141.9 98.9 38.4 134 SER 78.8 94.2 48.1 135 PRO 67.5 54.2 63.2 136 GLN 20.6 13.9 78.7 137 HIS 116.7 77.7 60.1 138 THR 105.5 98.7 31.9 139 TYR 175.1 96.8 45.4 140 PHE 166.6 99.9 38.5 141 ILE 140.8 98.1 34.0 142 ASN 119.1 98.5 53.9 143 CYS 99.2 100.0 50.4 144 GLY 34.8 100.0 60.4 145 ASP 98.1 88.8 58.3 146 SER 83.6 100.0 58.3 147 ARG 165.3 79.1 62.9 148 GLY 34.8 100.0 39.7 149 LEU 147.8 100.0 35.5 150 LEU 147.3 99.7 44.5 151 CYS 99.2 100.0 44.9 152 ARG 172.2 82.4 54.3 153 ASN 47.3 39.1 69.1 154 ARG 60.2 28.8 81.6 155 LYS 46.8 27.0 84.8 156 VAL 104.5 88.0 49.5 157 HIS 81.4 54.2 63.4 158 PHE 128.9 77.3 47.8 159 PHE 97.5 58.4 64.1 160 THR 103.7 97.0 46.0 161 GLN 41.7 28.1 83.1 162 ASP 90.4 81.8 68.4 163 HIS 142.9 95.2 68.3 164 LYS 115.2 66.5 66.7 165 PRO 124.5 100.0 47.4 166 SER 55.2 66.0 61.4 167 ASN 77.0 63.7 64.9 168 PRO 23.8 19.1 76.3 169 LEU 26.0 17.6 84.2 170 GLU 129.5 93.4 58.6 171 LYS 101.1 58.3 71.0 172 GLU 43.8 31.6 77.2 173 ARG 178.6 85.5 63.7 174 ILE 143.5 100.0 41.8 175 GLN 78.4 52.7 72.8 176 ASN 34.8 28.8 77.4 177 ALA 72.6 100.0 52.1 178 GLY 0.0 0.0 84.1 179 GLY 30.6 87.9 62.8 180 SER 45.6 54.5 55.1 181 VAL 117.1 98.5 48.4 182 MET 59.0 37.0 75.0 183 ILE 2.2 1.5 87.1 184 GLN 60.9 41.0 65.3 185 ARG 93.8 44.9 73.8 186 VAL 118.8 100.0 39.3 187 ASN 75.3 62.3 58.9 188 GLY 20.0 57.6 61.8 189 SER 32.9 39.3 78.2 190 LEU 119.0 80.5 52.5 191 ALA 50.9 70.1 71.2 192 VAL 108.8 91.6 56.0 193 SER 83.6 100.0 45.5 194 ARG 168.9 80.9 63.4 195 ALA 72.6 100.0 50.2 196 LEU 147.8 100.0 36.1 197 GLY 34.8 100.0 43.5 198 ASP 103.2 93.4 45.0 199 PHE 132.5 79.5 60.1 200 ASP 37.8 34.2 63.4 201 TYR 143.6 79.3 46.4 202 LYS 167.9 96.9 56.8 203 CYS 38.3 38.6 85.4 204 VAL 85.6 72.0 63.2 205 HIS 0.0 0.0 90.9 206 GLY 0.0 0.0 82.6 207 LYS 112.5 64.9 68.3 208 GLY 13.7 39.3 59.6 209 PRO 34.6 27.8 64.8 210 THR 83.4 78.1 55.9 211 GLU 64.3 46.4 69.2 212 GLN 138.8 93.4 59.5 213 LEU 127.8 86.4 47.5 214 VAL 118.8 100.0 48.1 215 SER 82.2 98.4 54.8 216 PRO 121.6 97.7 48.4 217 GLU 97.0 69.9 60.6 218 PRO 124.2 99.8 37.7 219 GLU 79.2 57.1 72.1 220 VAL 112.3 94.5 41.0 221 HIS 85.0 56.6 60.6 222 ASP 89.3 80.9 45.3 223 ILE 125.5 87.5 55.8 224 GLU 23.2 16.8 87.0 225 ARG 170.0 81.4 58.7 226 SER 58.4 69.9 74.7 227 GLU 37.6 27.1 78.2 228 GLU 29.2 21.1 84.5 229 ASP 54.6 49.4 71.0 230 ASP 108.4 98.1 44.7 231 GLN 128.5 86.5 47.0 232 PHE 166.8 100.0 29.5 233 ILE 143.5 100.0 26.9 234 ILE 143.1 99.8 28.4 235 LEU 147.8 100.0 35.6 236 ALA 72.6 100.0 39.8 237 CYS 99.1 99.9 56.5 238 ASP 82.3 74.5 77.1 239 GLY 34.8 100.0 61.7 240 ILE 143.5 100.0 31.9 241 TRP 203.2 99.1 52.8 242 ASP 36.1 32.7 75.3 243 VAL 90.5 76.2 58.7 244 MET 158.8 99.6 43.1 245 GLY 7.0 20.0 76.9 246 ASN 98.1 81.2 40.9 247 GLU 63.2 45.6 72.6 248 GLU 66.4 47.9 69.6 249 LEU 147.7 100.0 25.7 250 CYS 99.2 100.0 44.6 251 ASP 74.1 67.1 67.1 252 PHE 166.3 99.7 43.3 253 VAL 117.6 99.0 25.0 254 ARG 179.2 85.8 55.0 255 SER 71.9 86.0 58.5 256 ARG 198.2 94.9 49.9 257 LEU 143.8 97.3 38.4 258 GLU 83.7 60.4 56.2 259 VAL 103.3 86.9 60.4 260 THR 84.7 79.3 60.3 261 ASP 28.9 26.1 66.5 262 ASP 52.0 47.0 67.5 263 LEU 146.3 99.0 51.0 264 GLU 101.0 72.9 68.3 265 LYS 84.7 48.8 73.2 266 VAL 118.7 99.9 42.3 267 CYS 98.6 99.4 50.6 268 ASN 86.4 71.5 62.7 269 GLU 94.3 68.1 59.1 270 VAL 117.5 98.9 27.1 271 VAL 118.8 100.0 40.7 272 ASP 94.2 85.2 60.6 273 THR 104.7 97.9 40.7 274 CYS 99.2 100.0 37.6 275 LEU 139.4 94.3 44.2 276 TYR 163.1 90.1 55.8 277 LYS 139.3 80.3 54.4 278 GLY 3.6 10.4 81.6 279 SER 76.2 91.2 51.0 280 ARG 114.8 54.9 60.4 281 ASP 91.8 83.1 75.6 282 ASN 115.0 95.2 56.1 283 MET 159.4 100.0 45.2 284 SER 81.5 97.5 44.1 285 VAL 116.8 98.3 35.8 286 ILE 142.4 99.2 35.9 287 LEU 145.9 98.7 30.0 288 ILE 143.5 100.0 28.4 289 CYS 94.0 94.8 37.3 290 PHE 165.0 98.9 44.2 291 PRO 78.3 62.9 76.5 292 ASN 76.6 63.4 81.8 293 ALA 65.4 90.1 49.8 294 PRO 106.3 85.4 47.6 295 LYS 46.5 26.8 88.6 296 VAL 73.2 61.6 66.2 297 SER 48.9 58.5 57.2 298 PRO 16.4 13.2 81.5 299 GLU 30.1 21.7 75.6 300 ALA 59.0 81.3 58.8 301 VAL 57.6 48.5 64.4 302 LYS 35.0 20.2 80.9 303 LYS 51.6 29.7 81.1 304 GLU 112.6 81.2 67.8 305 ALA 15.6 21.5 76.9 306 GLU 37.3 26.9 71.7 307 LEU 132.6 89.7 49.8 308 ASP 75.9 68.7 56.3 309 LYS 48.0 27.7 78.6 310 TYR 74.9 41.4 59.3 311 LEU 147.8 100.0 29.8 312 GLU 100.9 72.8 58.4 313 CYS 46.0 46.3 69.7 314 ARG 147.7 70.7 58.2 315 VAL 118.8 100.0 33.0 316 GLU 59.9 43.2 62.5 317 GLU 31.1 22.5 86.5 318 ILE 124.8 87.0 52.6 319 ILE 129.5 90.2 36.8 320 LYS 51.6 29.8 81.9 321 GLY 0.0 0.0 89.3 322 VAL 65.1 54.8 68.1 323 PRO 85.3 68.5 60.0 324 ASP 48.0 43.4 64.6 325 LEU 128.0 86.6 47.0 326 VAL 39.5 33.2 77.9 327 HIS 71.9 47.8 73.2 328 VAL 118.8 100.0 31.7 329 MET 131.4 82.5 45.7 330 ARG 71.3 34.1 72.7 331 THR 57.6 53.9 67.9 332 LEU 147.8 100.0 30.6 333 ALA 27.3 37.6 72.5 334 SER 19.1 22.8 78.6 335 GLU 97.5 70.3 59.7 336 ASN 10.7 8.8 90.1 337 ILE 139.6 97.3 38.0 338 PRO 29.7 23.8 83.1 339 SER 7.4 8.9 81.0 340 LEU 135.3 91.6 47.3 341 PRO 120.3 96.6 52.4 342 PRO 61.7 49.6 74.1 343 GLY 32.0 92.1 57.0 344 GLY 34.8 100.0 43.3 345 GLU 56.7 40.9 76.2 346 LEU 129.2 87.4 37.1 347 ALA 59.6 82.1 55.6 348 SER 81.6 97.6 50.0 349 LYS 169.3 97.6 49.3 350 ARG 155.4 74.4 49.5 351 ASN 59.1 48.9 74.3 352 VAL 86.0 72.4 60.0 353 ILE 143.5 100.0 26.6 354 GLU 91.9 66.3 70.2 355 ALA 31.4 43.3 79.5 356 VAL 113.7 95.7 49.7 357 TYR 162.9 90.0 46.6 358 ASN 41.5 34.4 71.1 359 ARG 74.0 35.4 73.9 360 LEU 99.3 67.2 53.5 361 ASN 80.4 66.5 54.8 362 PRO 66.6 53.5 73.9 363 TYR 2.1 1.2 84.4